A5004486682- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Cardiac Arrest and Resuscitation
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Neuroprotection
- Congenital Ear and Nasal Anomalies
- Medicinal Plants and Bioactive Compounds
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Thermal Regulation in Medicine
- Bacteriophages and microbial interactions
- Wnt/β-catenin signaling in development and cancer
- Ichthyology and Marine Biology
- Genomics, phytochemicals, and oxidative stress
- Acute Kidney Injury Research
- Genetic and phenotypic traits in livestock
- Cardiovascular Conditions and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Brucella: diagnosis, epidemiology, treatment
- Gut microbiota and health
- Comparative Animal Anatomy Studies
- Ginger and Zingiberaceae research
- Nanocluster Synthesis and Applications
- Moringa oleifera research and applications
- Veterinary Orthopedics and Neurology
Jeonbuk National University
2016-2025
New York University
2022
Chonbuk National University Hospital
2015
Jeonju University
2015
Rural Development Administration
2012
University of Pennsylvania
2007-2010
The synthesis of luminescent and biocompatible carbon quantum dots is demonstrated from cabbage, a new carbonaceous biomaterial, for bio-imaging.
The importance of probiotics in swine production is widely acknowledged as crucial. However, gaps still remain the exact roles played by modulation gut microbiota and immune response. This study determined probiotic Lactobacillus plantarum strain JDFM LP11in response weaned piglets. L. LP11 increased population lactic acid bacteria feces enhanced development villi small intestine. Metagenome analysis showed that microbial diversity richness (Simpson, Shannon, ACE, Chao1) relative abundance...
Globally, gastric ulcer is a vital health hazard for human. Rabdosia inflexa (RI) has been used in traditional medicine inflammatory diseases. The present study aimed to investigate the protective effect and related molecular mechanism of RI using lipopolysaccharide (LPS)-induced inflammation RAW 246.7 cells HCl/EtOH-induced mice. We applied 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), nitric oxide (NO), reactive oxygen species (ROS), histopathology, malondialdehyde...
Two independent signals are necessary for neural crest (NC) induction in Xenopus: a Bmp signal, which must be partially attenuated by antagonists, and separate signal mediated either canonical Wnt or an Fgf. The mesoderm underlying the NC-forming region has been proposed as source of this second signal. Wnt8 Fgf8a expressed tissue around time NC therefore good candidate inducers. Loss-of-function studies indicate that both these ligands to specify NC; however, it is unclear whether signaling...
Oxidative stress plays a vital role in neurodegenerative diseases. Cornus officinalis (CC) has wide range of pharmacological activities (e.g., antioxidant, neuroprotective, and anti-inflammatory). The present study was undertaken to elucidate the neuroprotective mechanism CC fermented (FCC) on H2O2-induced oxidative damage rats SH-SY5Y cells. A dose 100 mg/kg or FCC orally administered 1 h prior immobilization 2 per day for 14 days. CC, especially administration decreased immobility time...
Sodium arsenite (NaAsO2) has been recognized as a worldwide health concern. Hydrangea macrophylla (HM) is used traditional Chinese medicine possessing antioxidant activities. The study was performed to investigate the therapeutic role and underlying molecular mechanism of HM on NaAsO2-induced toxicity in human liver cancer (HepG2) cells mice. hepatoprotective HepG2 assessed by using 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide (MTT), reactive oxygen species (ROS), lactate...
During evolution the vertebrate head has acquired a number of unique features including specialized paired sense organs and cranial sensory ganglia. These evolutionary novelties arise from discrete thickenings ectoderm known as placodes. They include adenohypophyseal, olfactory, lens, trigeminal, profundal, otic, epibranchial lateral line While distinct in derivatives cell types they will form, all placodes originate common preplacodal domain surrounding anterior neural plate. Recent...
Ulcerative colitis (UC) is a severe inflammatory disease that has spread throughout the world. Cirsium japonicum (CJ) and Aralia elata (AE) are natural herbs with potent antioxidative antidiabetics anti-inflammatory effects. In this investigation, we studied defensive role of combination CJ AE against LPS-induced inflammation in RAW 264.7 cells, dextran sulfate sodium (DSS)-induced mice, acetic acid-induced dogs. MTT assay was performed to identify toxic effect extracts. NO, MDA level also...
Mandibulofacial dysostosis (MFD) is a human congenital disorder characterized by hypoplastic neural-crest-derived craniofacial bones often associated with outer and middle ear defects. There growing evidence that mutations in components of the spliceosome are major cause for MFD. Genetic variants affecting function several core splicing factors, namely SF3B4, SF3B2, EFTUD2, SNRPB TXNL4A, responsible MFD five related but distinct syndromes known as Nager Rodriguez (NRS), microsomia (CFM),...
Stress can lead to inflammation, accelerated aging, and some chronic diseases condition. Mentha arvensis (MA) is a traditional medicine having antioxidant anti-inflammatory activities. The present study investigated the anti-stress role of MA fermented (FMA) extract in immobilized rats. We studied lipopolysaccharide (LPS)-induced inflammation RAW 264.7 cells rats were for 2 h per day 14 days using restraining cage. (100 mg/kg) FMA orally administered 1 prior immobilization. Using...
Free radical generation and oxidative stress push forward an immense influence on the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease Parkinson’s disease. Maclura tricuspidata fruit (MT) contains many biologically active substances, including compounds with antioxidant properties. The current study aimed to investigate neuroprotective effects MT hydrogen peroxide (H2O2)-induced neurotoxicity in SH-SY5Y cells. cells were pretreated MT, cell damage was induced by H2O2....
Transcription factors Pax3 and Zic1 are two important regulators of cell fate decision at the neural plate border, where they act synergistically to promote crest (NC) formation. To understand role these in NC development, we performed a microarray analysis identify downstream targets Xenopus embryos. Among genes identified was member transcription factor activator protein 2 (Tfap2) family, Tfap2 epsilon (Tfap2e). Tfap2e is first expressed early neurula stage progenitors Rohon-Beard sensory...