A5102810893- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Metastasis and carcinoma case studies
- Advanced Database Systems and Queries
- HIV/AIDS drug development and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug-Induced Hepatotoxicity and Protection
- Advanced Data Storage Technologies
- Semiconductor materials and devices
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Data Management and Algorithms
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Hepatitis Viruses Studies and Epidemiology
- Liver Diseases and Immunity
Chungnam National University Hospital
2015-2025
Chungnam National University
2016-2025
National Cancer Center
2024
Soonchunhyang University
2016-2024
Jeonbuk National University
2016-2024
National University College
2012-2024
New Generation University College
2012-2024
Keimyung University
2024
Inje University Ilsan Paik Hospital
2024
Chonnam National University Hwasun Hospital
2024
Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has been suggested as an effective therapy for liver cirrhosis. The efficacy and safety of autologous BM-MSC in the treatment alcoholic cirrhosis were investigated. Seventy-two patients with baseline biopsy-proven who had alcohol-abstinent more than 6 months underwent a multicenter, randomized, open-label, phase 2 trial. Patients randomly assigned to three groups: one control group two groups that either one-time or two-time...
Abstract Reactive oxygen species (ROS) contribute to the development of non-alcoholic fatty liver disease. ROS generation by infiltrating macrophages involves multiple mechanisms, including Toll-like receptor 4 (TLR4)-mediated NADPH oxidase (NOX) activation. Here, we show that palmitate-stimulated CD11b + F4/80 low hepatic macrophages, but not high Kupffer cells, generate via dynamin-mediated endocytosis TLR4 and NOX2, independently from MyD88 TRIF. We demonstrate differently LPS-mediated...
Table 1.Grading evidence and recommendations Evidence Notes High quality Further research is very unlikely to change our confidence in the estimate of effect A Moderate likely have an important impact on may B Low estimate.Any uncertain C Recommendation Strong Factors influencing strength recommendation included evidence, presumed patient-important outcomes, cost 1 Weak Variability preferences values, or more uncertainty.Recommendation made with less certainty, higher resource consumption 2
Multiphase CuInSe2 (CISe) nanoparticles including the CuSe phase are synthesized by microwave-assisted solvothermal method. Without additional processing, multiphase CISe facilitate solution-processed absorber layer with a dense microstructure, large grains, high crystallinity, and composition controllability, which essential for acceptable thin-film solar cell performance. The performance, cell, conversion efficiency of 8.2%, is obtained through transformation, microstructural evolution,...
The aim of this study was to reveal nationwide seroprevalence HCV infection in South Korea by a large-scale survey.From January December 2009, total 291 314 adults underwent health check-up 29 centres nationwide. data concerning anti-HCV antibody and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such as RNA, genotypes treatment detail additionally analysed.Using an estimated 2009 population Korea, the age, sex area-adjusted rate 0.78%. Anti-HCV...
Background & Aim To investigate the prevalence, mortalities, and patient characteristics of Acute-on-chronic liver failure (ACLF) according to AARC (Asian Pacific Association for Study Liver ACLF Research Consortium) European CLIF-C (Chronic Failure definitions. Methods We collected retrospective data 1470 hospitalized patients with chronic disease (CLD) acute deterioration between January 2013 December from 21 university hospitals in Korea. Results Of assessed, prevalence based on...
Growth differentiation factor 15 (GDF-15) belongs to the transforming growth factor-β superfamily. GDF-15 is emerging as a biomarker for several diseases. The aim of this study was determine clinical performances prediction liver fibrosis and severity in chronic disease.The serum levels were examined via enzyme immunoassay 145 patients with disease 101 healthy individuals. consisted 54 hepatitis, 44 compensated cirrhosis, 47 decompensated cirrhosis.Of diseases, cirrhosis had an increased...
Abstract Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex-derived reactive oxygen species (ROS) promote chronic liver inflammation and remodeling that can drive hepatocellular carcinoma development. The role of NOX expression in (HCC) has been partially investigated; however, the clinical relevance collective or individual family member for HCC survival remains unclear. Here, we obtained mRNA data 377 samples 21 normal controls from TCGA portal performed Kaplan-Meier...
Besifovir dipivoxil maleate (BSV) has activity against hepatitis B virus (HBV). We performed a phase 3 study to compare the antiviral efficacy and safety of BSV vs tenofovir disoproxil fumarate (TDF) in patients with chronic HBV infection Korea.We conducted double-blind, non-inferiority trial 197 at 22 sites South Korea, from November 2013 through February 2016. Patients were randomly assigned groups given (150 mg, n = 99) or TDF (300 98) for 48 weeks. evaluated virologic responses therapy...
(1) Background: Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death worldwide. Although various serum enzymes have been utilized for diagnosis and prognosis HCC, currently available biomarkers lack sensitivity needed to detect HCC at early stages accurately predict treatment responses. (2) Methods: We our highly sensitive cell-free DNA (cfDNA) detection system, in combination with a machine learning algorithm, provide platform improved HCC. (3) Results: cfDNA,...
Nonalcoholic fatty liver disease (NAFLD) is the most common worldwide. Ultrasound, used tool for diagnosing NAFLD, operator-dependent and shows suboptimal performance in patients with mild steatosis. However, few studies have been conducted on whether alternative noninvasive methods are useful hepatic Also, little known about tests grading severity of steatosis or degree intrahepatic inflammation. Therefore, we aimed to evaluate HSI, FLI HU values CT could be discriminate inflammation...
Abstract Hepatitis B virus (HBV) infection is the major cause of chronic liver disease in Korea. This study investigated seroprevalence HBV with an emphasis on coexistence hepatitis surface antigen (HBsAg) and antibody (anti‐HBs). In all, 290,212 people undergoing health check‐up examinations 29 institutions during 2009 were recruited. The crude seroprevalences HBsAg anti‐HBs was adjusted by age, sex, geographic area using estimated population 4.0% 73.5%, respectively. Males showed higher...
The current study examines the expression of molecular biomarkers in hepatocellular carcinoma (HCC) and whether these findings correlate with clinicopathologic features disease patient survival.We analyzed immunohistochemical p53, mammalian target rapamycin (mTOR), c-Met, insulin-like growth factor 1 receptor (IGF-1R) heat shock protein 70 (HSP70) 83 HCCs.p53 was higher male patients undifferentiated histological tumor grades, cirrhosis, portal vein invasion. High 48 c-Met correlated high...
Background/Aims Despite sexual function making an important contribution to the quality of life, data on erectile are relatively scant in patients with chronic liver disease. We evaluated prevalence and risk factors for dysfunction (ED) disease related hepatitis B, especially among those B (CHB) or early-stage cirrhosis. Methods In total, 69 (35 CHB 34 hepatitis-B-related cirrhosis [HBV-LC]) aged 40-59 years were analyzed. Child-Pugh classes A present 30 (88.2%) 4 (11.8%) HBV-LC,...
Highlights•IL-15 upregulates CCR5 in memory CD8+ T cells the absence of TCR stimulation•CCR5 is upregulated IL-15-induced bystander-activated cells•IL-15-treated migrate a CCR5-dependent manner•CCR5 upregulation associated with liver injury during acute hepatitis ASummaryDuring microbial infection, bystander that are not specific to infecting pathogens can be activated by interleukin (IL)-15. However, tissue-homing properties have been elucidated. Here, we examine effects IL-15 on expression...
Background/AimsBesifovir (BSV) showed comparable antiviral activity superior safety profiles to tenofovir disoproxil fumarate (TDF) in treatment-naïve chronic hepatitis B (CHB).However, no data are available regarding the efficacy and of BSV patients with CHB who switched from long-term TDF BSV.This study aimed evaluate outcome a 48-week therapy treatment. MethodsIn this non-inferiority trial, 153 treated for ≥48 weeks had virus (HBV) DNA <20 IU/mL were randomized receive either 150 mg or...
No studies have investigated the effects of radiologic-pathologic discordance on outcomes patients who undergone resection for hepatocellular carcinoma (HCC). Therefore, we these discrepancies such patients. This study included diagnosed with HCC magnetic resonance imaging underwent resection, including 1,790 from Korean Primary Liver Cancer Registry (nationwide cohort) and 185 Chungnam National University Hospital (hospital cohorts). Radiologic-pathologic in five factors (maximum tumor...
Background: Disease recurrence is the primary cause of death in patients with gastric cancer who have undergone complete surgical resection. No prognostic factors for recurrence, other than Tumor, Node, and Metastasis stage, been established. However, rates differ even within same stage. Therefore, we aimed to develop a new confidence measure demonstrate its practical utility. Methods: This was retrospective study based on medical records Chungnam National University Hospital, Republic...
A middle-1x nm design rule multi-level NAND flash memory cell (M1X-NAND) has been successfully developed for the first time. 1) QSPT (Quad Spacer Patterning Technology) of ArF immersion lithography is used patterning mid-1x wordline (WL). In order to achieve high performance and reliability, several integration technologies are adopted, such as 2) advanced WL air-gap process, 3) floating gate slimming 4) optimized junction formation scheme. And also, by using 5) new N±1 Vpass scheme during...
Background/Aims: Although notably common, irritable bowel syndrome (IBS) has no specific cure.Lifestyle modification may be as important medication; however, few studies support the effectiveness of such modifi cations.We performed this observational study IBS patients to explore further role lifestyle changes in treatment.Methods: This included 831 men who enlisted 2010 armed surgeon cadets and 85 women concurrently entered Armed Forces Nursing Academy.Of these 916 participants, 89 were...
Background/Aims: This study aimed to describe the healthrelated quality of life (HRQoL) outcomes for Korean chronic hepatitis C patients and investigate impact patient virus-related factors on HRQoL.Methods: HRQoL was assessed in 235 virus (HCV)-infected from seven nationwide tertiary hospital, including those with liver cirrhosis hepatocellular carcinoma (HCC), using Shor-Form 36 (SF-36) version 2 European questionnaire-5 dimensions (EQ-5D-3L).Results: The SF-36 physical (48.8±8.3) mental...