A5100720436- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Artificial Intelligence in Healthcare
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Radiomics and Machine Learning in Medical Imaging
- Organ Transplantation Techniques and Outcomes
- Alcohol Consumption and Health Effects
- Drug-Induced Hepatotoxicity and Protection
- Nutrition and Health in Aging
- Cancer Mechanisms and Therapy
- Liver Diseases and Immunity
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Multiple Myeloma Research and Treatments
- Liver physiology and pathology
- Mesenchymal stem cell research
- Hepatitis Viruses Studies and Epidemiology
- Magnetic and transport properties of perovskites and related materials
- Cytomegalovirus and herpesvirus research
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Pharmacy and Medical Practices
Catholic University of Korea
2016-2025
Bucheon St. Mary's Hospital
2023-2025
Uijeongbu St. Mary's Hospital
2015-2024
Ewha Womans University
2022
Weatherford College
2021
Daegu Health College
2021
Creative Commons
2021
Seoul St. Mary's Hospital
2013-2018
Eulji General Hospital
2002
Objective Lipiodol transcatheter arterial chemoembolization (TACE) is widely used to treat hepatocellular carcinoma (HCC). Recently, a drug-eluting bead (DEB) has been developed enhance drug delivery the tumor and reduce its systemic availability. The purpose of this study was compare efficacy safety intra-arterial injection DEB loaded with doxorubicin versus conventional, Lipiodol-based TACE regimens in Asian patients HCC. Methods designed as case–control, single-institution clinical trial....
Background & Aim To investigate the prevalence, mortalities, and patient characteristics of Acute-on-chronic liver failure (ACLF) according to AARC (Asian Pacific Association for Study Liver ACLF Research Consortium) European CLIF-C (Chronic Failure definitions. Methods We collected retrospective data 1470 hospitalized patients with chronic disease (CLD) acute deterioration between January 2013 December from 21 university hospitals in Korea. Results Of assessed, prevalence based on...
Abstract Purpose: Given its heterogeneity and diverse clinical outcomes, precise subclassification of Barcelona Clinic Liver Cancer stage C (BCLC-C) hepatocellular carcinoma (HCC) is required for appropriately determining patient prognosis selecting treatment. Experimental Design: We recruited 2,626 patients with BCLC-C HCC from multiple centers, comprising training/test (n = 1,693) validation cohorts 933). The XGBoost model was chosen maximum performance among the machine learning (ML)...
See the commentary-article "Which treatment modality should we choose for advanced hepatocellular carcinoma?" on page 353.
This study examined prevalence and risk factors of periodontitis in representative samples Korean adults, with without diabetes mellitus (DM).Data from the 2012 National Health Nutritional Examination Survey were analyzed. A total 4,477 adults (≥ 30 years old) selected 8,057 individuals who completed a nutrition survey, self-reported general health behavior questionnaire, an oral examination, hygiene behaviors laboratory tests. DM was defined as fasting plasma glucose ≥ 126 mg/dL, or...
The aim of this study was to investigate the role gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) in predicting histological grade hepatocellular carcinoma (HCC) according hepatic function. Eighty-one consecutive patients with 122 histologically proven HCCs who underwent Gd-EOB-DTPA-enhanced MRI before resection (45 42 patients) or transplantation (77 39 were analyzed retrospectively. We calculated relative enhancement...
Background/Aims Acute decompensation (AD) is defined as the development of complications related to portal hypertension and liver dysfunction that affect progression chronic disease (CLD) or cirrhosis (LC). Variations exist in patient demographics prognostic outcomes AD based on aetiology CLD, encompassing LC. However, limited research has been conducted analyse these discrepancies across aetiologies.
/Aims: This study aimed to evaluate the performance of Model for End-Stage Liver Disease (MELD) 3.0 predicting mortality and liver-related complications compared with Child-Pugh classification, albumin-bilirubin (ALBI) grade, MELD, MELD sodium (MELDNa) score. We evaluated a multicenter retrospective cohort incorporated patients cirrhosis between 2013 2019. conducted comparisons area under receiver operating characteristic curve (AUROC) MELD3.0 other models 3-month mortality. Additionally, we...
Recipients of liver transplantation (LT) require long-term immunosuppressive drug treatment, but lifelong treatment has severe side effects. It is known that some LT recipients develop immune tolerance, and although the development such operational tolerance should allow a decrease in burden factors indicate are not clear. This study aimed to monitor immunological markers over time identify those indicating tolerance. We performed prospective pilot measuring including ratio regulatory T...
Background/Aims: This study examined the risk factors associated with mortality in cirrhotic patients hospitalized variceal bleeding, and evaluated effects of acute-on-chronic liver failure (ACLF) on prognosis these patients.Methods: was retrospectively conducted registered Korean cohort, 474 consecutive bleeding from January 2013 to December at 21 university hospitals. ACLF defined as described by European Association for Study Liver-Chronic Liver Failure Consortium.Results: Among a total...
Background/Aims Transarterial chemoembolization (TACE) is widely performed as a major treatment for hepatocellular carcinoma (HCC) patients, and there need to stratify patients whom the most benefit from treatment. This study aimed develop refined prediction model overall survival (OS) in undergoing TACE first-line large cohort validate its performance. Methods A total of 2,632 with HCC Barcelona Clinic Liver Cancer stage or B who underwent between 2008 2017 were enrolled. The randomly...
Quick sequential organ failure assessment (qSOFA) is believed to identify patients at risk of poor outcomes in those with suspected infection. We aimed evaluate the ability modified qSOFA (m-qSOFA) high-risk among acutely deteriorated chronic liver disease (CLD), especially acute-onchronic (ACLF).
Abstract Background and Aim The Model for End‐Stage Liver Disease (MELD) is a reliable prognostic tool short‐term outcome prediction in patients with end‐stage liver disease. MELD 3.0 was introduced to enhance the predictive accuracy. This study assessed performance of 3.0, comparison MELD‐Na, alcoholic cirrhosis. Methods multicenter prospective cohort comprised cirrhosis admitted acute deterioration function Republic Korea between 2015 2019. compared abilities MELD, 30‐day 90‐day outcomes,...
The aim of this study was to validate the chronic liver failure-sequential organ failure assessment score (CLIF-SOFAs), CLIF consortium (CLIF-C OFs), CLIF-C acute-on-chronic ACLFs), and acute decompensation in Korean disease patients with deterioration.Acute-on-chronic defined by either Asian Pacific Association for Liver ACLF Research Consortium (AARC) or criteria. diagnostic performances short-term mortality were compared area under receiver operating characteristic curve.Among a total...
Abstract Background & Aims Sequential therapy posed a high risk of emergence multidrug resistance and presented management issue in chronic hepatitis B ( CHB ) treatment. We evaluated the antiviral efficacy safety entecavir ETV plus tenofovir TDF combination multidrug‐resistant MDR patients. Methods In this prospective, multicentre study, patients, defined as measurable serum HBV DNA (≥60 IU/ml) while on any rescue treatment regimen for at least 24 weeks presence documented prior...
The comparative efficacy and safety between lenvatinib hepatic artery infusion chemotherapy (HAIC) in patients with unresectable hepatocellular carcinoma (HCC) is still unclear. This multicenter historical cohort study enrolled 244 who were treated HAIC (n = 173) or 71) 2012 2020. Propensity score matching (PSM) was performed, 52 selected per group. Clinical outcomes compared. Objective response rate (ORR) not different the two groups (26.0% vs. 23.1%, p 0.736). Before PSM, group had a...