A5037098078- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Artificial Intelligence in Healthcare
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Hepatitis Viruses Studies and Epidemiology
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- HIV/AIDS drug development and treatment
- Liver Diseases and Immunity
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Viral-associated cancers and disorders
- Renal cell carcinoma treatment
- Drug-Induced Hepatotoxicity and Protection
- MRI in cancer diagnosis
- Advanced Radiotherapy Techniques
Catholic University of Korea
2016-2025
Seoul St. Mary's Hospital
2015-2025
University of California, Los Angeles
2024
Eunpyeong Hospital
2019
St. Paul's Hospital
2015-2019
Singapore General Hospital
2018
SingHealth
2018
National Cancer Centre Singapore
2018
Singapore Clinical Research Institute
2018
Duke-NUS Medical School
2018
Purpose Selective internal radiation therapy or radioembolization (RE) shows efficacy in unresectable hepatocellular carcinoma (HCC) limited to the liver. This study compared safety and of RE sorafenib patients with locally advanced HCC. Patients Methods SIRveNIB (selective v sorafenib), an open-label, investigator-initiated, phase III trial, yttrium-90 ( 90 Y) resin microspheres 800 mg/d HCC a two-tailed designed for superiority/detriment. were randomly assigned 1:1 stratified by center...
Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has been suggested as an effective therapy for liver cirrhosis. The efficacy and safety of autologous BM-MSC in the treatment alcoholic cirrhosis were investigated. Seventy-two patients with baseline biopsy-proven who had alcohol-abstinent more than 6 months underwent a multicenter, randomized, open-label, phase 2 trial. Patients randomly assigned to three groups: one control group two groups that either one-time or two-time...
Sorafenib is first-line standard of care for patients with advanced hepatocellular carcinoma (HCC), yet it confers limited survival benefit. Therefore, we aimed to compare clinical outcomes sorafenib combined concurrent conventional transarterial chemoembolization (cTACE) vs. alone in HCC.In this investigator-initiated, multicenter, phase III trial, were randomized receive (Arm S, n = 169) or combination cTACE on demand C, 170). was started within 3 days and 7-21 randomization. The primary...
Abstract Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory cells (Tregs) HCC patients treated with TACE. Whole blood was obtained for analysis (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17A, IL-22, IFN-γ, TNF-α) Tregs from 142 patients. Patients CTP class A had significantly lower proportion detectable IL-4 or but higher IL-22 than B/C. IL-6 level well correlated...
Abstract Background We evaluated the long-term effect of stereotactic body radiation therapy (SBRT) for primary small hepatocellular carcinoma (HCC) ineligible local or surgery. Methods Forty-two HCC patients with tumors ≤ 100 cc and ablation surgical resection were treated SBRT: 30-39 Gy a prescription isodose range 70-85% (median 80%) was delivered daily in three fractions. Median tumor volume 15.4 (3.0-81.8) median follow-up duration 28.7 months (8.4-49.1). Results Complete response (CR)...
Reactivation of hepatitis B virus (HBV) during chemotherapy is well documented. However, there are limited data on this complication in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemotherapy. The aim study was to evaluate the efficacy preemptive lamivudine therapy reducing due HBV reactivation HCC chemo-lipiodolization (TACL) and seek predictors event. A total 73 consecutive TACL using epirubicin 50 mg/m2 cisplatin 60 at monthly intervals were prospectively...
Abstract Background The objectives of this retrospective study was to evaluate the efficacy stereotactic body radiation therapy (SBRT) for small non-resectable hepatocellular carcinoma (HCC) and SBRT combined with transarterial chemoembolization (TACE) advanced HCC portal vein tumor thrombosis (PVTT). Methods Thirty one patients who were treated used study. We studied 32 lesions, where 23 lesions (22 patients) targeting primary HCC, 9 (9 PVTT using Cyberknife. All received TACE HCC. Tumor...
Table 1.Grading evidence and recommendations Evidence Notes High quality Further research is very unlikely to change our confidence in the estimate of effect A Moderate likely have an important impact on may B Low estimate.Any uncertain C Recommendation Strong Factors influencing strength recommendation included evidence, presumed patient-important outcomes, cost 1 Weak Variability preferences values, or more uncertainty.Recommendation made with less certainty, higher resource consumption 2
Objective The use of tenofovir (TDF) and entecavir (ETV) in patients with chronic hepatitis B (CHB) has led to a decrease the incidence hepatocellular carcinoma (HCC) liver-related events. However, whether there is difference between two agents extent improving such outcomes not been clarified thus far. Therefore, we aimed compare TDF ETV on risk HCC mortality. Design A total 7015 consecutive CHB who were treated or February 2007 January 2018 at liver units Catholic University Korea screened...
Background Natural killer (NK) cells can recognize and kill cancer directly, but their activity be attenuated by various inhibitory molecules expressed on the surface. The expression of epithelial cell adhesion molecule (EpCAM), a potential marker for stem (CSCs), is known to strongly associated with poor clinical outcomes in hepatocellular carcinoma (HCC). NK targeting CSCs may promising strategy anti-tumor therapy, little about how they respond EpCAM high HCC. Methods was assessed...
Background and aims: The underlying molecular mechanisms of hepatocellular carcinoma (HCC) remain poorly understood due to its complex development process. human T cell-specific transcription factor sex-determining region Y-related high-mobility group (HMG) box 4 ( SOX4 ) has been linked tumorigenesis. In this study, we characterized the roles in regulation p53 activity evaluated expression patterns prognostic value HCC. Methods: levels were examined HCC samples obtained from 58 patients...
Mechanisms associated with the progression of non-alcoholic fatty liver disease (NAFLD) remain unclear. We attempted to identify pattern altered gene expression at different time points in a high fat diet (HFD)-induced NAFLD mouse model. The early up-regulated genes are mainly involved innate immune responses, while late represent inflammation processes. Although recent studies have shown that microRNAs play important roles hepatic metabolic functions, pivotal role is not fully understood....
The role of clinical parameters such as systemic inflammatory response syndrome (SIRS) criteria in predicting the infection remains unclear cirrhosis patients. aim was to evaluate usefulness markers including C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) for diagnosis outcomes hospitalized cirrhotic study included 184 patients consecutively from 2011 2012. presence overt survival evaluated. CRP concentration, NLR, Model End-Stage Liver Disease (MELD) score SIRS were...
Liver cirrhosis is one of the major complications hepatitis C virus (HCV) infection, but mechanisms underlying HCV-related fibrogenesis are still not clear. Although roles HCV core protein remain poorly understood, it supposed to play an important role in regulation cellular growth and hepatocarcinogenesis. The aim this study was examine on hepatic fibrogenesis. We established vitro co-culture system with primary stellate cell (HSC) isolated from rats, a stable HepG2-HCV line which had been...
Hepatitis B virus (HBV) is one of the major causative agents chronic liver diseases in Korea. HBV has been classified into 8 genotypes by a divergence >8% entire genomic sequence, and have distinct geographic distributions. There are limited data on relevance between clinical outcomes To investigate feature relating to genotype Korea, total 120 serum samples with HBsAg (65 from Seoul 55 other city Korea) were obtained each 30 carriers asymptomatic carrier (ASC), hepatitis (CH), cirrhosis...