A5016712780- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Liver Disease and Transplantation
- Mosquito-borne diseases and control
- Hepatocellular Carcinoma Treatment and Prognosis
- Hemoglobinopathies and Related Disorders
- Viral Infections and Vectors
- Diabetes Management and Research
- Liver Diseases and Immunity
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Malaria Research and Control
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Iron Metabolism and Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism, Diabetes, and Cancer
- Influenza Virus Research Studies
- Diabetes Treatment and Management
- Pneumonia and Respiratory Infections
- Data Management and Algorithms
- Animal Virus Infections Studies
Ministry of Health
1991-2025
University Of Medicine 1 Yangon
2020-2025
Myanmar Oxford Clinical Research Unit
1989-2024
National Management Degree College
2009-2019
National Cancer Centre Singapore
2018
Singapore Clinical Research Institute
2018
Duke-NUS Medical School
2018
SingHealth
2018
Singapore General Hospital
2018
Ministry of Health and Sports
2018
Purpose Selective internal radiation therapy or radioembolization (RE) shows efficacy in unresectable hepatocellular carcinoma (HCC) limited to the liver. This study compared safety and of RE sorafenib patients with locally advanced HCC. Patients Methods SIRveNIB (selective v sorafenib), an open-label, investigator-initiated, phase III trial, yttrium-90 ( 90 Y) resin microspheres 800 mg/d HCC a two-tailed designed for superiority/detriment. were randomly assigned 1:1 stratified by center...
In the Asia-Pacific region and elsewhere, almost 85% of patients with hepatocellular carcinoma (HCC) are inoperable at diagnosis have a dismal prognosis. Tamoxifen (TMX) is believed to inhibit HCC positive for estrogen receptor (ER), but most HCCs ER negative. Results previous phase 3 trials in been conflicting inconclusive. At higher doses, however, TMX inhibits through ER-independent mechanisms. A multicenter randomized controlled trial was performed assess role high-dose versus placebo...
Satellite precipitation products from the Global Precipitation Measurement (GPM) mission and its predecessor Tropical Rainfall Measuring Mission (TRMM) are a critical data source for hydrological applications in ungauged basins. This study conducted an initial early evaluation of performance Integrated Multi-satellite Retrievals GPM (IMERG) final run TRMM Analysis 3B42V7 products, their feasibility streamflow simulations Chindwin River basin, Myanmar, April 2014 to December 2015 was also...
A genomic characterization of hepatitis B virus (HBV) was done for 56 pre-S1/pre-S2 genes and 10 full-length HBV genotype C isolates from five Asian countries. Phylogenetic analysis the revealed two major groups within C: one southeast Asia including Vietnam, Myanmar Thailand (named HBV/C1) other Far East Japan, Korea China HBV/C2). This finding confirmed by phylogenetic based on sequence 32 isolates, 22 database entries. Two Okinawa, island off southern end formed a different branch....
OBJECTIVE Human regular U-500 (U-500R) insulin (500 units/mL) is increasingly being used clinically, yet its pharmacokinetics (PK) and pharmacodynamics (PD) have not been well studied. Therefore, we compared PK PD of clinically relevant doses U-500R with the same human U-100 (U-100R) (100 units/mL). RESEARCH DESIGN AND METHODS This was a single-site, randomized, double-blind, crossover euglycemic clamp study. Single subcutaneous injections 50- 100-unit U-100R were administered to 24 healthy...
ABSTRACT It has been reported that hepatitis B virus (HBV) mutants carrying mutations in the pre-S region can be found infected patients. In this study, we investigated prevalence of HBV variant with mutant different geographic regions, including countries low and high levels endemic infection, analyzed correlation clinical findings. We examined 387 DNA-positive serum samples from individuals among 12 countries, consisting Vietnam, Myanmar, Thailand, China, Korea, Nepal, Japan, Russia,...
We assessed the effect of transforming growth factor-β1 on proliferation human Ito cells. cells in their myofibroblastlike phenotype were grown from explants liver and characterized with electron microscopy positive immunostaining for desmin smooth muscle α-actin. Transforming was mitogenic whatever culture conditions, although it was, as previously described, inhibitory rat The likely due to induction autocrine platelet-derived factor chain secretion by themselves because (a) blocked...
The safety and tolerability of sequential radioembolization-sorafenib therapy is unknown. An open-label, single arm, investigator-initiated Phase II study (NCT0071279) was conducted at four Asia-Pacific centers to evaluate the efficacy in patients with hepatocellular carcinoma (HCC) not amenable curative therapies.Sorafenib (400 mg twice-daily) initiated 14 days post-radioembolization yttrium-90 (90Y) resin microspheres given as a procedure. primary endpoints were best overall response rate...
This study used the Global Burden of Disease data (2010-2021) to analyze rates and trends point prevalence, annual incidence, years lived with disability (YLDs) for metabolic dysfunction-associated steatotic liver disease (MASLD) in 204 countries. Total numbers age-standardized per 100,000 population MASLD YLDs were compared across regions countries by age, sex, sociodemographic index (SDI). Smoothing spline models evaluate relationship between burden SDI. Estimates reported uncertainty...
ABSTRACT By PCR screening, we found an extremely high prevalence of TT virus (TTV) in the general populations from different geographic regions. This suggests that TTV may be a common DNA with no clear disease association humans. genotyping by phylogenetic analysis was also performed.
This study was performed to determine the prevalence and distribution of hepatitis C virus (HCV) genotypes in Myanmar.A total 1333 peripheral blood samples were collected from four different border cities Myanmar. The anti-HCV antibody-positive serum identified. HCV genotyped by reverse transcriptase polymerase chain reaction, direct DNA sequencing phylogenetic analysis on partial core genome.The overall infection 11.6% (154/1333). Regionally, it 13.5% (47/349) north-eastern city, 12.8%...