A5052319064- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- interferon and immune responses
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Diet, Metabolism, and Disease
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Liver Diseases and Immunity
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Cytokine Signaling Pathways and Interactions
- COVID-19 epidemiological studies
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- RNA modifications and cancer
Erasmus MC
2016-2025
Southwest Medical University
2024-2025
Guangzhou University of Chinese Medicine
2024
Nanjing Medical University
2024
Nanchang University
2024
First Affiliated Hospital of Nanchang University
2024
Erasmus University Rotterdam
2011-2023
Minzu University of China
2018-2022
Indian Institute of Technology Indore
2022
State Ethnic Affairs Commission
2020-2021
The ongoing epidemic of coronavirus disease 2019 (COVID-19) is devastating, despite extensive implementation control measures. outbreak was sparked in Wuhan, the capital city Hubei province China, and quickly spread to different regions across all other Chinese provinces. As recorded by Center for Disease Control Prevention (China CDC), Feb 16, 2020, there had been 70 641 confirmed cases 1772 deaths due COVID-19, with an average mortality about 2·5%.1Chinese PreventionDistribution new...
Recent evidence indicates there is a role for small membrane vesicles, including exosomes, as vehicles intercellular communication. Exosomes secreted by most cell types can mediate transfer of proteins, mRNAs, and microRNAs, but their in the transmission infectious agents less established. studies have shown that hepatocyte-derived exosomes containing hepatitis C virus (HCV) RNA activate innate immune cells, HCV between hepatocytes remains unknown. In this study, we investigated whether...
Hepatitis E virus (HEV) represents the main cause of acute hepatitis worldwide. HEV infection in immunocompromised patients involves a high risk for development chronic hepatitis. Because is recognized as zoonotic pathogen, it currently believed that swine primary reservoir. However, this not sufficient to justify strikingly seroprevalence both developing and Western countries. Thus, study aimed identify new sources bear transmission humans. We collected fecal, blood, milk samples cows...
Cancer-associated fibroblasts (CAFs) play a key role in the cancer process, but research progress is hampered by paucity of preclinical models that are essential for mechanistic dissection cell-CAF interactions. Here, we aimed to establish 3-dimensional (3D) organotypic co-cultures primary liver tumor-derived organoids with CAFs, and understand their interactions response treatment.Liver tumor CAFs were cultured from murine human tumors. 3D co-culture Transwell culture systems established...
Abstract Background The emerging of psychological problems triggered by COVID-19 particularly in children have been extensively highlighted and emphasized, but original research this respect is still lagging behind. Therefore, we designed study to evaluate the impact pandemic on mental health effectiveness attitudes towards online education among Chinese aged 7–15 years. Methods A detailed questionnaire, comprising 62 questions was parents or caretakers 7 15 years old were invited...
Background: The global burden of metabolic diseases is increasing, but estimates their impact on primary liver cancer are uncertain. We aimed to assess the attributable risk factors, including high body mass index (BMI) and fasting plasma glucose (FPG) levels, between 1990 2021. Methods: total number age-standardized rates deaths disability-adjusted life years (DALYs) from each factor were extracted Global Burden Disease Study 1990-2021. trends across regions countries by sociodemographic...
Recent animal and human studies have highlighted the potential of hepatocyte-derived microRNAs (HDmiRs) in serum as early, stable, sensitive, specific biomarkers liver injury. Their usefulness transplantation, however, has not been addressed. The aim this study was to investigate HDmiRs markers hepatic injury rejection transplantation. Serum samples from healthy controls transplant recipients (n = 107) peritransplant allograft biopsy 45) were analyzed via real-time polymerase chain reaction...
<h3>Background/aims</h3> RNA interference (RNAi), a sequence-specific gene silencing technology triggered by small interfering (siRNA), represents promising new avenues for treatment of various liver diseases including hepatitis C virus (HCV) infection. In plants and invertebrates, RNAi provides an important mechanism cellular defence against viral pathogens is dependent on the spread siRNA to neighbouring cells. A study was undertaken investigate whether vector-delivered can transfer...
ABSTRACT Hepatitis E virus (HEV) is a common cause of acute hepatitis that results in high mortality pregnant women and may establish chronic infections immunocompromised patients. We demonstrate for the first time alpha interferon (IFN-α) ribavirin inhibit vitro HEV replication both subgenomic replicon an infectious culture system based on genotype 3 strain. IFN-α showed moderate but significant synergism with ribavirin. These findings corroborate reported clinical effectiveness drugs. In...
Novel systemic treatments for hepatocellular carcinoma (HCC) are strongly needed. Immunotherapy is a promising strategy that can induce specific antitumor immune responses. Understanding the mechanisms of resistance by HCC crucial development suitable immunotherapeutics. We used immunohistochemistry on tissue-microarrays to examine co-expression inhibiting molecules PD-L1, Galectin-9, HVEM and IDO, as well tumor CD8+ lymphocyte infiltration in HCC, two independent cohorts patients. found at...
Human mesenchymal stem/stromal cells (MSCs) have been explored in a number of clinical trials as possible method treating various diseases. However, the effect long-term cell expansion vitro on physiological function and genetic stability is still poorly understood. In this study, MSC cultures derived from bone marrow liver were evaluated for presence aberrant following expansion. 46 independent cultures, four batches transformed MSCs (TMCs) found, which all beyond culture period five weeks....
Hepatitis E virus (HEV), as a hepatotropic virus, is supposed to exclusively infect the liver and only cause hepatitis. However, broad range of extrahepatic manifestations (in particular, idiopathic neurological disorders) have been recently reported in association with its infection. In this study, we demonstrated that various human neural cell lines (embryonic stem cell–derived lineage cells) induced pluripotent neurons primary mouse are highly susceptible HEV Treatment interferon-α or...