A5100680937- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Spinal Fractures and Fixation Techniques
- Bone fractures and treatments
- Viral Infections and Immunology Research
- Medical Imaging and Analysis
- Hip and Femur Fractures
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Liver Disease and Transplantation
- Total Knee Arthroplasty Outcomes
- Macrophage Migration Inhibitory Factor
- Musculoskeletal Disorders and Rehabilitation
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Autophagy in Disease and Therapy
- Cervical and Thoracic Myelopathy
- Orthopaedic implants and arthroplasty
- Intelligent Tutoring Systems and Adaptive Learning
- Stroke Rehabilitation and Recovery
- Tunneling and Rock Mechanics
- Automotive and Human Injury Biomechanics
- Erosion and Abrasive Machining
North Sichuan Medical University
2024
Tianjin University of Science and Technology
2023-2024
Haier Group (China)
2024
Hainan Medical University
2024
Hebei Agricultural University
2024
Hainan Medical College Hospital
2024
Guangxi University
2024
Southern University of Science and Technology
2023
Southeast University
2019
Nanjing Drum Tower Hospital
2019
ABSTRACT Hepatitis E virus (HEV) is a common cause of acute hepatitis that results in high mortality pregnant women and may establish chronic infections immunocompromised patients. We demonstrate for the first time alpha interferon (IFN-α) ribavirin inhibit vitro HEV replication both subgenomic replicon an infectious culture system based on genotype 3 strain. IFN-α showed moderate but significant synergism with ribavirin. These findings corroborate reported clinical effectiveness drugs. In...
Hepatitis E virus (HEV), as a hepatotropic virus, is supposed to exclusively infect the liver and only cause hepatitis. However, broad range of extrahepatic manifestations (in particular, idiopathic neurological disorders) have been recently reported in association with its infection. In this study, we demonstrated that various human neural cell lines (embryonic stem cell–derived lineage cells) induced pluripotent neurons primary mouse are highly susceptible HEV Treatment interferon-α or...
Interferons (IFNs) are broad antiviral cytokines that exert their function by inducing the transcription of hundreds IFN‐stimulated genes (ISGs). However, little is known about potential these cellular effectors on hepatitis E virus (HEV) infection, leading cause acute globally. In this study, we profiled a panel important human ISGs HEV replication in cell culture models overexpression an individual ISG. The mechanism action key anti‐HEV ISG was further studied. We identified retinoic...
A tripartite transcription factor complex mediates an interferon-independent antiviral response.
ABSTRACT Viruses are solely dependent on host cells to propagate; therefore, understanding virus-host interaction is important for antiviral drug development. Since de novo nucleotide biosynthesis essentially required both cell metabolism and viral replication, specific catalytic enzymes of these pathways have been explored as potential targets. In this study, we investigated the role different enzymatic cascades in hepatitis E virus (HEV) replication. By profiling various pharmacological...
IFN regulatory factor 1 (IRF1) is one of the most important IFN-stimulated genes (ISGs) in cellular antiviral immunity. Although hepatitis E virus (HEV) a leading cause acute worldwide, how ISGs counteract HEV infection largely unknown. This study was conducted to investigate effect IRF1 on replication. Multiple cell lines were used 2 models that harbor HEV. In different culture systems, effectively inhibited did not trigger production, and chromatin immunoprecipitation sequencing data...
Abstract IFN-α has been used for decades to treat chronic hepatitis B and C as an off-label treatment some cases of E virus (HEV) infection. TNF-α is another important cytokine involved in inflammatory disease, which can interact with interferon signaling. Because interferon-stimulated genes (ISGs) are the ultimate antiviral effectors signaling, this study aimed understand regulation ISG transcription activity by TNF-α. In study, inhibited replication HCV 71 ± 2.4% HEV 41 4.9%....
The outcomes of hepatitis E virus (HEV) infection are diverse, ranging from asymptomatic carrier, self-limiting acute infection, and fulminant to persistent infection. This is closely associated with the immunological status host. study aimed understand innate cellular immunity as first-line defense mechanism in response HEV Phosphorylation signal transducer activator transcription 1, a hallmark activation antiviral interferon (IFN) response, was observed liver tissues majority HEV-infected...
Besides abstinence, no effective treatment exists for alcohol-related liver disease (ALD), a dreaded consequence of alcohol abuse. In this study, we assessed the roles on ALD dual specificity phosphatase-1 (DUSP1), an hepatoprotective enzyme, and Cullin-1 (CUL1), member E3 ubiquitin ligase complex that exerts also transcriptional suppression mitochondrial genes. Alcohol downregulated hepatic DUSP1 expression in wild-type mice. Notably, transgenic (Dusp1Tg ) mice showed resistance to...
The coupled Euler-Lagrange (CEL) method and finite-discrete element (FDEM) are adopted to simulate the rock fracture process induced by high-pressure water jet solve problems of highly nonlinear, fluid-solid coupling large deformation. is characterized CEL model, can flow freely in Euler mesh, which better actual shape jets. integrated into FEDM produced embedding zero-thickness cohesive elements. traction-separation criterion used damage. In simulation jet, infinite elements realize...
Although various factors may contribute to its initiation and progression, the etiology prognosis of endometrial carcinoma (EC) remains not fully understood. We sought understand role changes in transcriptome during progress EC by exploring public datasets. The aberrant expression characteristics based on RNA-Seq miRNA-seq data from Cancer Genome Atlas ( TCGA ) were analyzed. Kaplan-Meier analysis was performed assess relationship between differently expressed genes DEGs patient survival. As...
PL intervention significantly up-regulated the expression levels of cAMP in brain, with subsequent transfer to spleen which promoted phosphorylation p65 and IκBα.
ABSTRACT Hepatitis E virus (HEV) infection has emerged as a global health problem. However, no approved medication is available, and the biology remains largely elusive. Electron transport chain (ETC), key component of mitochondria, main site that produces ATP reactive oxygen species (ROS). By profiling role different complexes mitochondrial ETC, we found pharmacological inhibition complex III, well‐defined drug target for treatment malaria Pneumocystis pneumonia, potently restricts HEV...
Norovirus is a major cause of acute gastroenteritis worldwide and has emerged as an important issue chronic infection in transplantation patients. Since no approved antiviral available, we evaluated the effects different immunosuppressants ribavirin on norovirus explored their mechanisms action by using human (HuNV) replicon-harboring model surrogate murine (MNV) infectious model. The roles corresponding drug targets were investigated gain- or loss-of-function approaches. We found that...
Black garlic (Allium sativum L.) melanoidins (MLDs) are produced by Maillard reaction under high temperature and humidity, has a variety of biological activities. The aim this study was to analyze the structural characteristics investigate α-amylase α-glucosidase in vitro inhibitory activity black MLDs.Spectroscopic chemical analysis revealed that MLDs were heterogeneous macromolecular polymers with skeletal structure similar sugar chains. Molecular weight distribution 3DEEM fluorescence...