A5030921510- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 and healthcare impacts
- Alcohol Consumption and Health Effects
- COVID-19 Clinical Research Studies
- Eosinophilic Esophagitis
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- COVID-19 epidemiological studies
- Family and Patient Care in Intensive Care Units
- Colorectal Cancer Screening and Detection
- COVID-19 diagnosis using AI
- Amino Acid Enzymes and Metabolism
- Respiratory Support and Mechanisms
- Healthcare Systems and Reforms
- Organ Transplantation Techniques and Outcomes
- Social and Behavioral Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Chronic Lymphocytic Leukemia Research
- Substance Abuse Treatment and Outcomes
- COVID-19 and Mental Health
- Glycosylation and Glycoproteins Research
- Patient Satisfaction in Healthcare
University of Ghana
2017-2025
Korle Bu Teaching Hospital
2019-2024
Massachusetts Institute of Technology
2021
Industrialization has impacted the human gut ecosystem, resulting in altered microbiome composition and diversity. Whether bacterial genomes may also adapt to industrialization of their host populations remains largely unexplored. Here, we investigate extent which rates targets horizontal gene transfer (HGT) vary across thousands strains from 15 spanning a range industrialization. We show that HGTs have accumulated over recent generations HGT occurs at high frequency within individuals....
Abstract Binge drinking (BD) is a common pattern of alcohol consumption among adolescents. At present few data are available on the possible relationship between BD and use disorders (AUD) in The aim this study was to assess prevalence behavior AUD A total 2704 students attending 10 purposively selected high schools from three Italian provinces were surveyed. Questionnaires regarding socio-demographic data, amount intake, smoking habits, illicit drugs, physical activity administered....
This study used the Global Burden of Disease data (2010-2021) to analyze rates and trends point prevalence, annual incidence, years lived with disability (YLDs) for metabolic dysfunction-associated steatotic liver disease (MASLD) in 204 countries. Total numbers age-standardized per 100,000 population MASLD YLDs were compared across regions countries by age, sex, sociodemographic index (SDI). Smoothing spline models evaluate relationship between burden SDI. Estimates reported uncertainty...
Background. Acute kidney injury (AKI) is one of the most severe complications cirrhosis and portends an ominous prognosis with estimated mortality about 50% in a month 65% within year. Infection hypovolemia have been found to be main precipitating factors AKI liver cirrhosis. Early detection treatment may improve outcomes. patients Ghana their impact on inpatient are largely unknown. This study was aimed at determining prevalence, factors, predictors, in-hospital admitted district hospital...
Introduction: Upper Gastrointestinal (UGI) symptoms are among the commonest complaints for which patients seek medical attention. Characteristics of undergoing UGI endoscopy (UGIE) at district hospital in Ghana largely unknown. This study was to document demographic characteristics, indications and endoscopic findings UGIE Ghana.
Tuberculosis (TB) and HIV are strongly linked. There is a 19 times increased risk of developing active TB in people living with than HIV-negative Sub-Saharan Africa being the hardest hit region. According to WHO, 1.3 million died from TB, an additional 300,000 TB-related deaths among HIV. Although some progress has been made reducing due evolution diagnostics, treatment antiretroviral treatment, multi drug resistant becoming source worry. Though significant at national level, understanding...
Abstract Burnout among physicians is associated with poor productivity at work, dissatisfaction, and regrets about career choices. The present study aims to evaluate the prevalence of burnout its main factors young Italian Internists. An online survey assessing different aspects training working conditions internists was conducted across European countries by Young Internists Group Federation Internal Medicine (EFIM). Only data from respondents were analyzed in study. Data 106 (aged < 40...
Alcohol consumption and inadequate fruits vegetable (FnV) intake are major reasons for the shift from communicable to non-communicable diseases (NCDs) over years. The older Ghanaian adult is at high risk of NCD data on alcohol FnV required guide policy mitigate its effect. This analysis aimed determine factors associated with assess relationship between among Ghanaians aged 50 years older.This used WHO Study Global Ageing Adult Health (SAGE) Wave 2, Ghana set conducted 2014 2015. Data...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related mortality worldwide including sub-Saharan Africa. The GALAD score, derived from Gender, Age, Lens culinaris agglutinin-reactive fraction alpha fetoprotein, Alpha and Des-carboxy-prothrombin, has high accuracy in diagnosing HCC Asia, Europe, North America; however, it not been validated an African cohort. aim this study was to assess performance score diagnosis Clinical data patients with cirrhosis (n = 93) or 78)...
Background. Hepatic encephalopathy (HE) is one of the most debilitating complications cirrhosis leading to death. Decrease in HE mortality and recurrence has been linked with timely identification early treatment. There a need document burden, predictors, treatment outcomes an adult population liver our setting as only reports from resource-endowed countries abound literature. This study aimed therefore determine prevalence, patients admitted at St. Dominic Hospital (SDH) Akwatia, Ghana....
Hepatocellular carcinoma (HCC), the fourth most common cancer in Africa, has a dismal overall survival of only 3 months like sub-Saharan Africa. This is affected by low gross domestic product and human development index, absence coherent guidelines, other factors.
Background Chronic liver diseases including cirrhosis are a major cause of morbidity and mortality globally. Despite the high burden in Ghana, data on this disease is lacking. Objective To determine sociodemographic characteristics, reasons for admission, in-hospital patients with seen at district hospital Ghana. Methods A prospective study was conducted involving one hundred eighty-six (186) admitted medical wards St. Dominic from 1st January 2018 to 24th June 2020. The patient’s...
Hepatocellular carcinoma (HCC) is a cancer of global public health concern because its high incidence and mortality. The impact greatest in areas with prevalence major risk factors including chronic hepatitis B virus (HBV). HBV endemic Ghana but comprehensive data on HCC lacking. aim this study was to describe the clinical, laboratory radiological features at Korle Bu Teaching Hospital Ghana.The medical records 194 cases attended Gastrointestinal Clinic between January 2015 December 2018...
Abstract Background End-stage liver disease (ESLD) is a major burden on public health, particularly in sub-Saharan Africa, where hepatitis B virus (HBV) an important risk factor. We aimed to describe clinical characteristics of ESLD from cirrhosis or hepatocellular carcinoma (HCC) and the performance aspartate aminotransferase (AST)—platelet ratio index (APRI) alpha fetoprotein (AFP) Ghana. Methods performed observational cross-sectional study outpatient hepatology clinics at three teaching...
Abstract Hyperthyroidism may impact liver biochemistry negatively. Clinicians need a high index of suspicion in patients presenting with unexplained deranged enzymes or jaundice. Timely initiation thionamides portends good prognosis.
Alcoholic liver disease (ALD) is the most common in Western World. Liver transplantation (LT) treatment for end-stage ALD. However, many transplant centers are still reluctant to these patients because of risk alcohol relapse, recurrence primary and associated post-transplant complications. We examined survival rate, prevalence recurrence, re-transplantation complications among transplanted alcoholic cirrhosis compared with those viral cirrhosis.data about at Gemelli Hospital from January...
The coronavirus disease 2019 (COVID-19) outbreak in the Hubei province of China has rapidly transformed into a global pandemic. In response to first few reported cases COVID-19, government Ghana implemented comprehensive social and public health interventions aimed at containing disease, albeit its effect on medical education is less clear. Undoubtedly, COVID-19 brought changes that may impact plan career progression for both students faculty. Hitherto, had getting contact with patients...
Malnutrition is common among patients with end stage liver disease including cirrhosis and cancer. Optimal nutrition important to reduce morbidity mortality of these patients. There limited qualitative data on nutritional status management chronic We aimed explore the knowledge, opinions practices health workers in Ghana, order determine whether there a need improve care for conducted study using semi-structured interviews cirrhotic (n = 16) healthcare providers 27) three academic centers...
The study examined the clinical characteristics and outcomes of 2019 novel coronavirus disease (COVID-19) infections among hospitalized patients.
Extensive research suggests that positive patient experience leads to improvement in health outcomes. Patient is particularly important ambulatory care, where a builds long-term relationship with provider manage his/her chronic illness over the span of years. Despite these known benefits, and its impact on outcomes poorly understood low- middle-income countries, resources may be limited primary care infrastructure spotty.This paper aims better characterize tertiary teaching hospital Accra,...
WHO recommends hepatitis C (HCV) screening for all people living with HIV (PLHIV). Yet, HCV coinfection was shown to be rare in some Sub-Saharan cohorts, and targeted testing suggested more efficient such settings. We studied prevalence among Ghanaian PLHIV, assessed the external validity of a score guide testing. This initially derived from Cambodian cohort, uses as predictors: age, household member/partner liver disease, diabetes, generalized pruritus, AST, platelets, AST-to-platelet ratio...
Introduction: prevalence of upper gastrointestinal (UGI) symptoms in the general population is very high. Indications and findings patients undergoing endoscopy (UGIE) at regional hospitals Ghana are largely unknown. This study was to document indications endoscopic UGIE hospital Ghana.