A5046429346- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Biliary and Gastrointestinal Fistulas
- IgG4-Related and Inflammatory Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Screening and Detection
- Tracheal and airway disorders
- Colorectal and Anal Carcinomas
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Body Contouring and Surgery
- Gastroesophageal reflux and treatments
- Liver Disease and Transplantation
- Cancer Genomics and Diagnostics
Mayo Clinic
2016-2025
WinnMed
2016-2025
Mayo Clinic in Arizona
2015-2024
St. Paul's Hospital Millennium Medical College
2023-2024
The University of Texas MD Anderson Cancer Center
2005-2024
National Institute of Diabetes and Digestive and Kidney Diseases
2024
National Institutes of Health
2024
Mayo Clinic in Florida
2015-2023
University of Washington
2022
Hartford Financial Services (United States)
2019
Objectives To evaluate the efficacy of rituximab (RTX) in IgG4-related disease (IgG4-RD) an open-label pilot trial. Methods We treated 30 IgG4-RD patients with two doses RTX (1000 mg each). The participants were either alone (n = 26; 87%) or required to discontinue baseline glucocorticoids (GC) within 2 months 4; 13%). Disease activity was measured by Responder Index (IgG4-RD RI) and physician's global assessment (PGA). response defined as improvement RI points. primary outcome, at 6 months,...
To determine the sensitivity and specificity of elevated serum IgG4 level for diagnosis autoimmune pancreatitis (AIP) its ability to distinguish AIP from pancreatic cancer, main differential diagnosis.We measured levels (normal 8-140 mg/dL) in 510 patients including 45 with AIP, 135 62 no disease, 268 other diseases.Sensitivity, specificity, positive predictive values (>140 were 76%, 93%, 36%, respectively, 53%, 99%, 75%, >280 mg/dL. Among subjects IgG4, non-AIP (N = 32) differed 34) that...
There is a paucity of data on long-term management type 1 autoimmune pancreatitis (AIP), relapsing steroid-responsive disorder.We describe our experience with treatment relapses and maintenance remission using steroid-sparing immunomodulators (IMs) induction rituximab (RTX).We obtained details disease relapse in 116 AIP patients from clinic visits, medical records telephone interviews. We compared free survival those treated IMs versus steroids alone, assessed patients' response to RTX,...
BACKGROUND AND AIMS Recent consensus guidelines suggest that presence of ≥1 the following is an indication for resection (IR) branch duct intraductal papillary mucinous neoplasm (IPMN-Br): cyst-related symptoms, main pancreatic diameter ≥10 mm, cyst size ≥30 intramural nodules, or fluid cytology suspicious/positive malignancy. Among a cohort patients with IPMN-Br we determined if IR (CIR), multifocal IPMN-Br, growth on follow-up predict METHODS We identified 147 whom 66 underwent surgical at...
BACKGROUND Celiac plexus neurolysis and block are considered safe but provide limited pain relief. Standard techniques target the region of celiac do not attempt injections directly into ganglia. The recent recognition that ganglia can be visualized by endoscopic ultrasound (EUS) now allows direct injection for (CGN) (CGB). AIMS To determine safety initial efficacy (at 2–4 wk) in patients with moderate to severe secondary unresectable pancreatic carcinoma or chronic pancreatitis. METHODS An...
BACKGROUND AND AIMS Standard techniques for evaluating bile duct strictures have poor sensitivity detection of malignancy. Newer imaging modalities, such as intraductal ultrasound (IDUS), and advanced cytologic techniques, digital image analysis (DIA) fluorescence in situ hybridization (FISH), identify chromosomal abnormalities, may improve while maintaining high specificity. Our aim was to prospectively evaluate the accuracy these patients with indeterminate biliary strictures. METHODS...
The objective of this study was to evaluate and validate cyst fluid carcinoembyronic antigen (CEA) amylase in differentiating (1) nonmucinous from mucinous pancreatic cystic lesions (PCLs), (2) benign malignant PCLs, (3) pseudocysts nonpseudocysts (amylase only).
<h3>Objective</h3> Pancreatic cysts are commonly detected in patients undergoing pancreatic imaging. Better approaches needed to characterise these lesions. In this study we evaluated the utility of detecting mutant DNA secretin-stimulated juice. <h3>Design</h3> Secretin-stimulated juice was collected from duodenum 291 subjects enrolled Cancer Pancreas Screening trials at five US academic medical centres. The population included with a familial predisposition cancer who underwent screening,...