A5056226095- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- HIV/AIDS drug development and treatment
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Colorectal Cancer Surgical Treatments
- Helicobacter pylori-related gastroenterology studies
- Organ Transplantation Techniques and Outcomes
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Abdominal vascular conditions and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal and GI Pathology
- Alcohol Consumption and Health Effects
- Vascular Procedures and Complications
- Diet, Metabolism, and Disease
- Viral gastroenteritis research and epidemiology
- Genetic factors in colorectal cancer
- Cancer Mechanisms and Therapy
Konkuk University
2015-2024
Konkuk University Medical Center
2012-2021
Chung-Ang University
2019
Seoul National University Hospital
2019
Seoul National University
2019
Services Hospital
2008
Harvard University
2005
Massachusetts General Hospital
2005
Sungkyunkwan University
2001-2002
Samsung Medical Center
2001-2002
Table 1.Grading evidence and recommendations Evidence Notes High quality Further research is very unlikely to change our confidence in the estimate of effect A Moderate likely have an important impact on may B Low estimate.Any uncertain C Recommendation Strong Factors influencing strength recommendation included evidence, presumed patient-important outcomes, cost 1 Weak Variability preferences values, or more uncertainty.Recommendation made with less certainty, higher resource consumption 2
Although a small amount of fecal material can obscure significant colorectal lesions, it has not been well documented whether bowel preparation status affects the missing risk polyps and adenomas during colonoscopy.We prospectively enrolled patients with one to nine at least adenoma >5 mm in size screening colonoscopy. Tandem colonoscopy polypectomy was carried out within 3 months.A total 277 942 714 completed index tandem examinations. At colonoscopy, 187 (19.9%) 127 (17.8%) were missed....
We developed hepatitis C virus (HCV) core-E1-E2 and HCV core transgenic mice on a common genetic background to assess the contribution of structural proteins hepatocarcinogenesis. Eight-week-old core-E1-E2, core, nontransgenic inbred FVB×C57Bl/6 were treated with diethylnitrosamine (DEN) sacrificed at 32 weeks old. Proliferation apoptosis assessed by immunohistochemistry. The effect viral was evaluated in HepG2 cells which induced anti-Fas antibody. HCCs identified majority DEN-treated from...
Background & Aim To investigate the prevalence, mortalities, and patient characteristics of Acute-on-chronic liver failure (ACLF) according to AARC (Asian Pacific Association for Study Liver ACLF Research Consortium) European CLIF-C (Chronic Failure definitions. Methods We collected retrospective data 1470 hospitalized patients with chronic disease (CLD) acute deterioration between January 2013 December from 21 university hospitals in Korea. Results Of assessed, prevalence based on...
Clevudine (L-FMAU) is a thymidine l-nucleoside analogue that was recently introduced for the treatment of chronic hepatitis B virus infection. Previous studies showed clevudine has potent and sustained antiviral activity without causing viral resistance. No severe adverse event occurred during clinical trials. We describe two cases drug-induced myopathy long-term with clevudine.
Background/Aims A revised classification system for renal dysfunction in patients with cirrhosis was proposed by the Acute Dialysis Quality Initiative and International Ascites Club Working Group 2011. The aim of this study to determine prevalence according criteria proposal. Methods medical records cirrhotic who were admitted Konkuk University Hospital between 2006 2010 reviewed retrospectively. data obtained at first admission collected. kidney injury (AKI) chronic disease (CKD) defined...
Objective Direct comparison of the clinical outcomes between nucleos(t)ide analogue (NA) discontinuation versus NA continuation has not been performed in patients with chronic hepatitis B who achieved HBsAg-seroclearance. Whether was as safe after NA-induced surface antigen HBV (HBsAg) seroclearance investigated present study. Designs This multicentre study included 276 from 16 hospitals Korea HBsAg seroclearance: 131 (47.5%) discontinued treatment within 6 months (NA group) and 145 (52.5%)...
Functional gastrointestinal disorders are more common in women relation to the fluctuations of female sex hormones. We tried know gender-related differences prevalence irritable bowel syndrome and symptoms according menstrual phase. A total 253 before menopause 252 men below age 50 were examined by a gastroenterologist after completing questionnaire. Blood tests, endoscopic procedures, imaging studies done, if needed. Women subclassified into three groups their menstruation period; phase,...
ABSTRACT Clevudine (CLV) is a nucleoside analog with potent antiviral activity against chronic hepatitis B virus (HBV) infection. Viral resistance to CLV in patients receiving therapy has not been reported. The aim of this study was characterize CLV-resistant HBV viral breakthrough (BT) during long-term therapy. gene encoding reverse transcriptase (RT) analyzed from BT Sera collected the at baseline and time were studied. To mutations isolated patients, we subjected mutants vitro drug...
Background/Aims This study evaluated the clinical outcomes of balloon-occluded retrograde transvenous obliteration (BRTO) for treatment hemorrhage from gastric varices (GV) in Korean patients with liver cirrhosis (LC). Methods We retrospectively analyzed data 183 LC who underwent BRTO GV bleeding 6 university-based hospitals between January 2001 and December 2010. Results Of enrolled patients, 49 had Child-Pugh (CP) class A LC, 105 CP B, 30 C at time BRTO. was successfully performed 177...
Antiviral treatment for hepatitis B virus (HBV) e antigen (HBeAg)–positive chronic HBV infection is still controversial. We assessed whether antiviral reduces the risk of liver disease progression in these patients. This study included consecutive patients 8 large-volume hospitals Korea who tested positive HBeAg and had an DNA level >20000 IU/mL, alanine aminotransferase (ALT) <40 IU/L, no evidence cirrhosis. The primary end point was development hepatocellular carcinoma (HCC), secondary A...
The emergence of drug-resistant hepatitis B virus (HBV) is a major problem for antiviral treatment in chronic infection. In this study, we analyzed the evolution mutations and characterized effects rtA181T rtI233V on viral replication drug resistance. We performed clonal analysis HBV polymerase gene from serum samples during breakthrough treated with agents. A series mutant clones containing and/or were constructed determined effect these ability An vitro study revealed that mutation...
The model for end-stage liver disease (MELD) serves as an indicator short-term mortality among patients diagnosed with cirrhosis (LC) and is used to prioritize transplantation. In 2021, the updated version of MELD, MELD-3.0, was introduced improve accuracy prediction MELD. Therefore, this study aimed compare efficacy MELD 3.0 MELD-Na in predicting Korean LC.
AIM:To investigate hepatic function after combined transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) with a short-term interval (0-2 d). METHODS:A total of 115 patients compensated liver cirrhosis underwent RFA TACE at time-interval 0-2 d for the treatment hepatocellular carcinoma (HCC) < 5.0 cm.There were 21 who received further directed altering within 12 mo therapy HCC-recurrence, excluded.The remaining 94 survived without HCC-recurrence included in this...
Background: Liver biopsies have been partially replaced by noninvasive methods for assessing liver fibrosis.We explored the usefulness of four novel biomarkers, enhanced fibrosis (ELF), glycosylation isomer Mac-2 binding protein (M2BPGi), galectin-3, and soluble suppression tumorigenicity 2 (sST2), in association with fibrosis.Methods: ELF, M2BPGi, sST2 were assayed 173 patients chronic diseases.The results analyzed according to grade (F0/1, F2, F3/4) transient elastography (TE).Results:...
Abstract Background/Aims: There is no consensus on the management of patients with adefovir (ADV)‐resistant hepatitis B virus (HBV) infection. The aim this study was to investigate whether tenofovir disoproxil fumarate (TDF) combined lamivudine (LMV) effective and safe in resistance or non‐response ADV. Methods: Six HBV‐related cirrhosis, viral breakthrough during LMV therapy ADV were treated daily TDF plus for at least 6 months. HBV DNA level, alanine aminotransferase (ALT), Child–Pugh...
While gastric variceal bleeding (GVB) is not as prevalent esophageal bleeding, it reportedly more serious, with high failure rates of the initial hemostasis (>30%), and has a worse prognosis than bleeding. However, there limited information regarding for GVB. The aim this study was to determine retrospectively clinical outcomes GVB in multicenter Korea.The data 1,308 episodes (males:females=1062:246, age=55.0±11.0 years, mean±SD) were collected from 24 referral hospital centers South Korea...
The aim of this study was to validate the chronic liver failure-sequential organ failure assessment score (CLIF-SOFAs), CLIF consortium (CLIF-C OFs), CLIF-C acute-on-chronic ACLFs), and acute decompensation in Korean disease patients with deterioration.Acute-on-chronic defined by either Asian Pacific Association for Liver ACLF Research Consortium (AARC) or criteria. diagnostic performances short-term mortality were compared area under receiver operating characteristic curve.Among a total...
To evaluate the degree of liver fibrosis as a predictor mortality and hepatocellular carcinoma (HCC) development among patients with chronic hepatitis B.The level predicts liver-related complications.A total 542 over 18 years old B who visited Konkuk University Hospital between 2005 2006 were enrolled. We performed noninvasive tests (APRI, FIB-4) virus (HBV) DNA levels. The data on newly developed HCC collected during 5-year follow-up analyzed.In 5 years, 40 died 68 HCC. area under receiver...
Accurate detection of significant fibrosis (fibrosis stage 2 or higher on the METAVIR scale) is important especially for chronic hepatitis B (CHB) patients with high viral loads but normal mildly elevated alanine aminotransferase (ALT) levels because presence accepted as indication antiviral treatment. Liver biopsy reference standard diagnosing fibrosis, it an invasive procedure. Consequently, noninvasive imaging-based measurements, such magnetic resonance elastography (MRE) two-dimensional...