A5008038979- Lung Cancer Treatments and Mutations
- Neonatal Respiratory Health Research
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related Molecular Pathways
- Colorectal Cancer Treatments and Studies
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Pneumonia and Respiratory Infections
- Medical Imaging Techniques and Applications
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Health and Wellbeing Research
- Virus-based gene therapy research
- Gastric Cancer Management and Outcomes
- Bacterial Infections and Vaccines
- Congenital Diaphragmatic Hernia Studies
- Bone health and treatments
- Immunotherapy and Immune Responses
- PI3K/AKT/mTOR signaling in cancer
- Medical Imaging and Pathology Studies
- Colorectal Cancer Surgical Treatments
- Cancer therapeutics and mechanisms
- Psychosocial Factors Impacting Youth
University of Ulsan
2011-2025
Asan Medical Center
2011-2025
Ulsan College
2011-2025
Seoul National University
2007-2024
Hanyang University Seoul Hospital
2024
Seoul National University Hospital
2008-2023
Seoul National University Children's Hospital
2019-2023
Catholic University of Korea
2013-2021
New Generation University College
2010-2020
National University College
2020
Rationale Although a relationship between the Gas6/AXL pathway and pulmonary fibrosis (PF) has been suggested, precise mechanisms clinical implications of AXL in idiopathic (IPF) are still unclear. Methods Constitutive conditional AXL-knockout mice were generated injected with bleomycin (BLM) to induce fibrosis. The expression macrophage subtypes BLM-injected patients IPF was analysed using flow cytometry. therapeutic effects inhibitors examined. Results AXL-deficient resistant BLM-induced...
Treatment with gefitinib, a specific inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR-TK), has resulted in dramatic responses some patients non-small cell lung cancer (NSCLC). Most who respond to gefitinib have EGFR-TK mutations; however, >10% mutations do not respond. Similarly, without this drug, suggesting that other factors determine sensitivity gefitinib. Aberrations the tumor suppressor gene p53 are frequently associated drug resistance. In study, we investigated...
Mycoplasma pneumoniae is a major causative pathogen of community-acquired pneumonia in children, and the treatment choice macrolides. There an increasing trend reports refractory clinical responses despite macrolide due to emergence macrolide-resistant M. pneumoniae. Early discrimination macrolide-refractory (MrMP) from macrolide-sensitive (MSMP) vital; however, testing for susceptibility at time admission not feasible. This study aimed identify characteristics MrMP Korean comparison with...
Although ex vivo culture expansion is necessary to use autologous mesenchymal stem cells (MSCs) in treating stroke patients, and several researchers have utilized culture-expanded their studies, the effects of on neurogenesis trophic support are unknown. Thus, we evaluated impact passage MSCs a rat model. The IV application vivo-cultured human MSCs, earlier (passage 2) or later 6), was performed Behavioral tests, immunohistochemical quantitative analysis using CAST-grid system were evaluate...
Abstract Introduction Adenine nucleotide translocator (ANT) 2 is highly expressed in proliferative cells, and ANT2 induction cancer cells known to be directly associated with glycolytic metabolisms carcinogenesis. In addition, repression results the growth arrest of human implying that a candidate for therapy based on molecular targeting. Methods We utilized an ANT2-specific RNA interference approach inhibit expression evaluating its antitumor effect vitro vivo . Specifically, investigate...
Abstract Background Adenine nucleotide translocase (ANT) is located in the inner mitochondrial membrane and catalyzes exchange of ATP for cytosolic ADP. ANT has been known to be a major component permeability transition pore complex mitochondria contributes mitochondria-mediated apoptosis. Human four isoforms (ANT1, ANT2, ANT3, ANT4), expression variable depending on tissue cell type, developmental stage, proliferation status. Among isoforms, ANT1 highly expressed terminally-differentiated...
The development of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) seems almost inevitable, even in patients with lung cancer that initially respond well EGFR-TKIs. MET amplification was recently found be a mechanism escape from the anticancer effect EGFR inhibitors. In present study, we investigated means whereby affects sensitivity EGFR-TKIs PC-9 cells. Gefitinib- or erlotinib-resistant sublines were established by exposing parental cell line chronic,...
Background/Aims A revised classification system for renal dysfunction in patients with cirrhosis was proposed by the Acute Dialysis Quality Initiative and International Ascites Club Working Group 2011. The aim of this study to determine prevalence according criteria proposal. Methods medical records cirrhotic who were admitted Konkuk University Hospital between 2006 2010 reviewed retrospectively. data obtained at first admission collected. kidney injury (AKI) chronic disease (CKD) defined...
Mesoporous silica molecular sieves are emerging candidates for a number of potential applications involving adsorption and transport due to their large surface areas, high pore volumes, tunable sizes. Recently, several research groups have investigated the functionalized mesoporous as advanced materials in separation devices, such membranes. In particular, with two- or three-dimensional structure is one most promising types sieve gas However, important challenges must first be addressed...
Abstract We aimed to evaluate antiepileptic drug treatment persistence and adherence in paediatric epilepsy patients investigate the association between medication‐taking behaviours clinical outcome. Methods . Medical prescription records of newly treated patients, aged 1–18 years who initiated monotherapy a tertiary teaching hospital, were retrospectively reviewed. The rates overall treatment, non‐persistence, gap >60 days, adherence, as measured by medication possession ratio ≥0.8,...
Accumulating evidence has clarified that gut dysbiosis is involved in lung cancer development and progression. Although the relationship between tumors microbiota been extensively studied using clinical samples, no studies have examined association mutant EGFR-induced carcinogenesis microbiota. Therefore, we investigated profiles stool samples from human lung-specific conditional EGFR-mutant transgenic mice during tumor carcinogenesis. Stool were collected before tamoxifen treatment (V1) at...
The risk of osteoporosis or osteopenia is known to increase after childhood cancer treatment. purpose this study was evaluate patterns bone mineral density (BMD) and identify factors related the decreased BMD in survivors. We studied 78 patients (34 boys, 44 girls) treated for cancer. Twenty (25.7%) had lumbar (LBMD) standard deviation score (SDS) lower than -2. Nineteen (24.4%) femur neck (FNBMD) SDS with hematopoietic stem cell transplantation LBMD (-1.17 ± 1.39 vs -0.43 1.33, P = 0.025)....
Abstract Background Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL; apo2 ligand) induces apoptosis in cancer cells but has little effect on normal cells. However, many cell types are resistant to TRAIL-induced apoptosis, limiting the clinical utility of TRAIL as an anti-cancer agent. We previously reported that suppression adenine nucleotide translocase-2 (ANT2) by short-hairpin RNA (shRNA) breast cells, which frequently express high levels ANT2. In present study, we...
The hypothalamus, the center for body weight regulation, can sense changes in blood glucose level based on ATP-sensitive potassium (K(ATP)) channels hypothalamic neurons. We hypothesized that a lack of sensing hypothalamus affects regulations appetite and weight.To evaluate this hypothesis, responses to loading high fat feeding eight weeks were compared Kir6.2 knock-out (KO) mice control C57BL/6 mice, because is key component K(ATP) channel.The neuropeptide Y (NPY) analyzed one hour after...
Gemcitabine is used to treat several cancers including lung cancer. However, tumor cells often escape gemcitabine-induced cell death via various mechanisms, which include modulating bcl-2 family members and NF-κB activation. We previously reported that the C-terminal region of Bfl-1 fused with GFP (BC) sufficient induce apoptosis in 293T cells. In present study, we investigated anti-tumor effect combined BC gene therapy gemcitabine chemotherapy vitro vivo using non-small cancer lines a...
Abstract We demonstrate the use of combination therapy to overcome limitations cancer DNA vaccines by adding radioiodine gene in an animal model. established a stable cell line (CT26/hMUC1‐hNIS‐F luc : CMNF) expressing hMUC1, hNIS and F genes using retro‐ lentivirus system. The survival rates (%) CMNF cells were determined clonogenic assays after 131 I treatment. After i.m. immunization 4 groups Balb/c mice (pcDNA3.1, pcDNA3.1+ I, pcDNA3‐hMUC1+PBS pcDNA3‐hMUC1+ groups) with pcDNA3‐hMUC1 or...