A5101485436- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Asthma and respiratory diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmacology and Obesity Treatment
- HIV/AIDS drug development and treatment
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Allergic Rhinitis and Sensitization
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Estrogen and related hormone effects
- Biosimilars and Bioanalytical Methods
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Analytical Methods in Pharmaceuticals
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sexual function and dysfunction studies
- Drug-Induced Hepatotoxicity and Protection
- Antibiotics Pharmacokinetics and Efficacy
- Tuberculosis Research and Epidemiology
- Food Allergy and Anaphylaxis Research
Samsung (South Korea)
2021-2025
Dong-A University Hospital
2005-2024
Inje University
2015-2021
Dong-A University
2003-2021
Korea Institute of Toxicology
2021
Ewha Womans University
2017-2020
Samsung Medical Center
2012-2019
Pusan National University Yangsan Hospital
2019
University of Ulsan
2009-2019
Asan Medical Center
2009-2019
Background/aim: Isoniazid (INH) is an essential component of first-line anti-tuberculosis (TB) treatment. However, treatment with INH complicated by polymorphisms in the expression enzyme system primarily responsible for its elimination, N-acetyltransferase 2 (NAT2), and associated hepatotoxicity. The objective this study was to develop individualized dosing regimen using a pharmacogenetic-driven model apply pilot study. Methods: A total 206 patients TB who received anti-TB were included...
Objective The effects of various polymorphisms in cytochrome P450 (CYP) enzyme and transporter genes on the pharmacokinetics (PK) simvastatin were evaluated healthy Korean men. Methods Plasma concentration data for acid pooled from four phase I studies comprising 133 participants. CYP2D6*4, CYP2D6*5, CYP2D6*14, CYP2D6*41, CYP3A5*3, CYP2C19*2, CYP2C19*3, CYP2A6*7, CYP2A6*9; SLCO1B1 rs4149056, rs2306283, rs4149015; ABCB1 rs1128503, rs2032582, rs1045642; ABCG2 rs2231142 each participant....
ABSTRACT Twenty-two currently marketed antituberculosis drugs were comprehensively evaluated for their inhibitory effect on organic anionic transporter (OAT)- and cation (OCT)-mediated uptake using stably transfected HEK293 cells in vitro . We observed moderate to strong effects OAT1- OAT3-mediated para -aminohippurate (PAH) OCT1- OCT2-mediated N -methyl-4-phenylpylidinium acetate (MPP + ) uptake. Ciprofloxacin, linezolid, -aminosalicylic acid (PAS), rifampin have effects, with the...
ABSTRACT Introduction SB12 demonstrated equivalence to reference eculizumab (ECU) in complement inhibitor‐naïve patients with paroxysmal nocturnal hemoglobinuria (PNH) the previous randomized, double‐blind, multi‐national, crossover, Phase III study. Methods The scope of this post‐hoc study was subgroup analysis by race compare efficacy and safety ECU PNH Asian Non‐Asian subgroups Results including lactate dehydrogenase (LDH), number units packed red blood cells as primary secondary...
We investigated the inhibitory interaction potential of 22 currently marketed antituberculosis (TB) drugs on organic anion-transporting polypeptide 1B1 (OATP1B1)-, OATP2B1-, and OATP1B3-mediated uptake using in vitro Xenopus oocytes HEK cells. Rifabutin, ethambutol, amoxicillin, linezolid, p-amino salicylic acid, rifapentine exhibited mild to moderate effects OATP-mediated estrone-3 sulfate, estradiol 17β-d-glucuronide, rosuvastatin. The 50% concentration (IC50) values rifabutin, linezolid...
What is known and objective Vancomycin the drug of choice for methicillin-resistant Staphylococcus aureus (MRSA) infection shows time-dependent bacterial killing. The current study evaluated pharmacokinetics (PK) pharmacodynamics (PD) vancomycin explored its optimal dosing regimens by modeling simulation. Methods Pharmacokinetics was performed 20 patients who were treated with intravenously, 1000 mg, every 12 h, blood PK randomly drawn within prespecified time windows. PD in vitro time-kill...
para-Aminosalicylic acid (PAS) is a second-line antituberculosis drug that has been used to treat multidrug-resistant and extensively drug-resistant tuberculosis for more than 60 years. Renal secretion glomerular filtration are the major pathways elimination of PAS. We comprehensively studied PAS transport by using cell lines overexpressed various transporters found acts as novel substrate an organic anionic polypeptide (OATP1B1), cationic (OCT1 OCT2), anion (OAT1 OAT3) but not any...
Valsartan, an angiotensin-receptor blocker, and rosuvastatin, a competitive inhibitor of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, are frequently coadministered to treat patients with hypertension dyslipidemia. The study reported here sought evaluate pharmacokinetic pharmacodynamic interactions between rosuvastatin valsartan in healthy Korean subjects.Thirty male subjects were administered (20 mg/day), (160 both drugs concomitantly for 4 days randomized, open-label, multiple-dose,...
Data are lacking on the association between allergic rhinitis (AR) phenotype and sensitization to specific allergens or bronchial hyperresponsiveness (BHR) in children. We here investigated risk factors comorbidities, including BHR, for AR by its Impact Asthma (ARIA) classification a general population-based birth cohort study.We enrolled 606 children aged 7 years from Panel Study of Korean Children. The was assigned accordance with ARIA Skin prick tests Provocholine provocation test were...
To characterize the pharmacokinetics (PK) of letrozole by noncompartmental and mixed effect modeling analysis with exploration body compositions on PK.The PK data 52 normal healthy male subjects intensive sampling from two separate studies were included in this analysis. Subjects given a single oral administration 2.5 mg (Femara®), an antiestrogenic aromatase inhibitor used to treat breast cancer. Letrozole concentrations measured using validated high-performance liquid chromatography tandem...
Busulfan is an antineoplastic agent with a narrow therapeutic window. A post-hoc population pharmacokinetic analysis of prospective randomized trial for comparison four-times daily versus once-daily intravenous busulfan was carried out to search predictive factors (iBu) pharmacokinetics (PK). In this study the PK iBu characterized provide suitable dosing recommendations. Patients were receive iBu, either as 0.8 mg/kg every 6 h or 3.2 over 4 days prior hematopoietic stem cell transplantation....
Sarpogrelate hydrochloride is a selective 5-hydroxytryptamine receptor subtype 2A (5HT(2A)) antagonist that blocks serotonin-induced platelet aggregation. The aim of this study was to compare the pharmacokinetics sarpogrelate and its metabolite after dosing with controlledrelease (CR) formulation or an immediaterelease (IR) formulation.In open-label, 2-period, 2-treatment crossover study, 36 healthy male subjects were evenly allocated two groups in sequence-randomized manner. In first...
Abstract: Valproic acid (VPA) is mainly metabolized via glucuronide, which hydrolyzed by β-glucuronidase and undergoes enterohepatic circulation. Amoxicillin/clavulanic (AMC) administration leads to decreased levels of β-glucuronidase-producing bacteria, suggesting that these antibiotics could interrupt circulation thereby alter the pharmacokinetics VPA. This study aimed evaluate effects AMC on was an open-label, two-treatment, one-sequence in 16 healthy volunteers. Two treatments were...
Abstract: A fixed-dose combination of amlodipine and olmesartan is used to treat high blood pressure in patients whose hypertension not sufficiently controlled with either drug alone. The objective this study was evaluate the bioequivalence two combinations, ie, orotate/olmesartan medoxomil 10/40 mg besylate/olmesartan mg, healthy subjects. randomized, open-label, single-dose, two-sequence, two-period, crossover conducted 30 adult volunteers. Blood samples were collected for up 72 hours...
Anthracyclines, such as doxorubicin, are effective anticancer drugs composed of a tetracyclic polyketide aglycone and one or more deoxysugar moieties, which play critical role in their biological activity. A facile one-pot combinatorial biosynthetic system was developed for the generation range glycosylated derivatives anthracyclines. Cocultivation Streptomyces venezuelae mutants producing two anthracycline aglycones with eight different nucleotide deoxysugar-producing S. that coexpress...
Purpose: Adherence is a major component of successful medical treatment.However, nonadherence remains barrier to effective delivery healthcare worldwide.Methods: Twenty facilities (secondary or tertiary hospitals) belonging the Korean Academy Pediatric Allergy and Respiratory Diseases (KAPARD) participated.Questionnaires were given patients currently receiving treatment in form inhalant useor oral intake transdermal patch for mild moderate asthma.Results: A total 1,838 responded...
Background: For more effective and safer usage of antibiotics, the dosing strategy should be individualized based on patients' characteristics, including race.The aim this study was to investigate population pharmacokinetic (PK) profiles piperacillin tazobactam in Korean patients with acute infections.Materials Methods: At least four consecutive 2/0.25 g or 4/0.5 doses piperacillin/tazobactam (TZP) were intravenously infused over 1 h every 8 for creatinine clearance (CL cr ) ≤50 mL/min CL...