A5100434375- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Diabetes and associated disorders
- Phagocytosis and Immune Regulation
- Liver Diseases and Immunity
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Vitamin D Research Studies
- Liver Disease and Transplantation
- Autophagy in Disease and Therapy
- Fibroblast Growth Factor Research
- Preterm Birth and Chorioamnionitis
- Cancer-related Molecular Pathways
- Immunodeficiency and Autoimmune Disorders
- Periodontal Regeneration and Treatments
- Cannabis and Cannabinoid Research
- Macrophage Migration Inhibitory Factor
- Mycobacterium research and diagnosis
- Immune responses and vaccinations
- Immune cells in cancer
- Tuberculosis Research and Epidemiology
- Inflammatory Bowel Disease
Cedars-Sinai Medical Center
2019-2025
Seoul National University Hospital
2024
Kongju National University
2023
CHA University
2021
Konkuk University Medical Center
2020
Chemo (Spain)
2020
Bridge University
2020
Kyung Hee University
2013-2020
Hanyang University
2020
National Cancer Center
2020
Abstract Reactive oxygen species (ROS) contribute to the development of non-alcoholic fatty liver disease. ROS generation by infiltrating macrophages involves multiple mechanisms, including Toll-like receptor 4 (TLR4)-mediated NADPH oxidase (NOX) activation. Here, we show that palmitate-stimulated CD11b + F4/80 low hepatic macrophages, but not high Kupffer cells, generate via dynamin-mediated endocytosis TLR4 and NOX2, independently from MyD88 TRIF. We demonstrate differently LPS-mediated...
Non-alcoholic fatty liver disease (NAFLD) is a dominant cause of chronic disease, but the exact mechanism progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains unknown. Here, we investigated role exosomes in NAFLD progression. Exosomes were isolated human hepatoma cell line treated with palmitic acid (PA) and their miRNA profiles examined by microarray. The hepatic stellate (HSC) (LX-2) was then exosome hepatocytes. Compared controls, PA-treated hepatocytes...
During liver injury, hepatocytes secrete exosomes that include diverse types of self‐RNAs. Recently, self‐noncoding RNA has been recognized as an activator Toll‐like receptor 3 (TLR3). However, the roles hepatic and TLR3 in fibrosis are not yet fully understood. Following acute injury early‐stage induced by a single or 2‐week injection carbon tetrachloride (CCl 4 ), increased interleukin (IL)‐17A production was detected primarily γδ T cells wild‐type (WT) mice. IL‐17A were both significantly...
To determine whether magnetic resonance (MR) enterography performed with diffusion-weighted imaging (DWI) without intravenous contrast material is noninferior to material-enhanced (CE) MR for the evaluation of small-bowel inflammation in Crohn disease.Institutional review board approval and informed consent were obtained this prospective noninferiority study. Fifty consecutive adults suspected having disease underwent clinical assessment, enterography, ileocolonoscopy within 1 week. included...
Hyaluronan (HA), a major extracellular matrix glycosaminoglycan, is biomarker for cirrhosis. However, little known about the regulatory and downstream mechanisms of HA overproduction in liver fibrosis. Hepatic synthase 2 (HAS2) expression was elevated both human murine production fibrosis were reduced mice lacking HAS2 hepatic stellate cells (HSCs), whereas overexpressing had exacerbated transcriptionally up-regulated by transforming growth factor-β through Wilms tumor 1 to promote...
Abstract Growth differentiation factor 15 (GDF15) has recently been shown to have an important role in the regulation of mitochondrial function and pathogenesis complex human diseases. Nevertheless, GDF15 alcohol-induced or fibrotic liver diseases yet be determined. In this study, we demonstrate that alcohol- carbon tetrachloride (CCl 4 )-mediated hepatic production ameliorates inflammation fibrosis. Alcohol directly enhanced expression primary hepatocytes, which led increased oxygen...
Abstract Chronic inflammation is a driving force for the development of metabolic disease including diabetes and obesity. However, functional characteristics T-cell senescence in abnormal glucose homeostasis are not fully understood. We studied patients visiting hospital routine health check-ups, who were divided into two groups: normal controls people with prediabetes. Gene expression profiling peripheral blood mononuclear cells from type 2 was undertaken using microarray analysis. also...
Clinical trials and animal models suggest that infusion of bone marrow cells (BMCs) is effective therapy for liver fibrosis, but the underlying mechanisms are obscure, especially those associated with early effects BMCs. Here, we analyzed impact BMC identified subsets BMCs showing antifibrotic in mice carbon tetrachloride–induced fibrosis. An interaction between activated hepatic stellate (HSCs) was investigated using an vitro coculturing system. Within 24 hours, infused were close contact...
Hesperetin (3′,5,7-trihydroxy-4-methoxyflavanone) is a metabolite of hesperidin (hesperetin-7-O-rutinoside), which belongs to the flavanone subgroup and found mainly in citrus fruits. has been reported be an effective osteoinductive compound various vivo vitro models. However, how hesperetin effects osteogenic differentiation not fully understood. In this study, we investigated capacity stimulate periodontal ligament stem cells (PDLSCs) relieve anti-osteogenic effect high glucose....
Abstract The expression of chemokine receptor CX 3 CR1 is related to migration and signaling in cells the monocyte-macrophage lineage. precise roles liver have been investigated but not clearly elucidated. Here, we hepatic macrophages injury. Hepatic splenic low F4/80 monocytes CD16 − were differentiated into high or + by co-culture with endothelial cells. Moreover, CL1 deficiency human umbilical vein (HUVECs) attenuated interleukin-1β (IL-1β) tumor necrosis factor-α (TNF-α), whereas...
The Aurora (Ipl) kinase family plays important roles in the regulation of mitosis and tumorigenesis. tumor suppressor RASSF1A controls mitotic progression by regulating anaphase-promoting complex (APC)-Cdc20 activity microtubule stability, but mechanism which this action is regulated has not been previously established. Here, we show that A B associate with phosphorylate on serine 203 vivo at different times subcellular compartments during mitosis. Notably, both depletion RNA interference...
1α,25-dihydroxyvitamin D3 (1,25D3), the most popular drug for osteoporosis treatment, drives osteoblast differentiation and bone mineralization. Wnt/β-catenin signaling is involved in commitment of osteoblasts, but role Dickkopf-related protein 1 (DKK1), a Wnt antagonist, osteoblasts remains unknown. Here, we demonstrate molecular mechanism DKK1 induction by 1,25D3 its physiological during differentiation. markedly promoted expression both CCAAT/enhancer binding beta (C/EBPβ) at day 7...
Effective therapies for alcohol-associated liver disease (ALD) are limited; therefore, the discovery of new therapeutic agents is greatly warranted. Toll-like receptor 7 (TLR7) a pattern recognition single-stranded RNA, and its activation prevents fibrosis. We examined intestinal damage in Tlr7-/- mice to determine role TLR7 ALD pathogenesis. In an alcoholic hepatitis (AH) mouse model, hepatic steatosis, injury, inflammation were induced by chronic binge ethanol feeding mice, Tlr7 deficiency...
Plant-derived phenolic compounds, such as hydroxytyrosol and hydroxysalidroside, have a beneficial impact on human health owing to their antioxidant activity. In this study, we used Escherichia coli synthesize hydroxytyrosol. Tyrosine decarboxylase from Papaver somniferum, tyrosine oxidase Micrococcus luteus, 4-hydroxyphenylacetate 3-monooxygenase E. were transformed into the bacterial cell. The resulting transformant successfully synthesized Furthermore, engineered strains ~ 268.3 mg/L...
Steatotic liver enhances metastasis of colorectal cancer, but this process is not fully understood. induced by a high-fat diet (HFD) increases cancer-associated fibroblast (CAF) infiltration and collagen hyaluronic acid (HA) production. We investigated the role HA synthase 2 (HAS2) in fibrotic tumor microenvironment steatotic using Has2ΔHSC mice, which Has2 deleted from hepatic stellate cells. mice had reduced steatotoic liver-associated metastatic growth MC38 cancer cells, deposition, CAF...
Abstract Emerging evidence revealed that diabetes induces abnormal immune responses result in serious complications organs. However, the effect of hyperglycemia on hepatic immunity remains obscure. We evaluated population and function cells streptozotocin (STZ)-induced hyperglycemic mice. CC chemokine receptor 2 (CCR2)-knockout mice with a depletion regulatory T (DEREG) were used to investigate migration role (Tregs) The inflammatory cytokines transaminase levels significantly increased...
Young-Sun Lee, Hyon-Seung Yi, Yang-Gun Suh, Jin-Seok Byun, Hyuk Soo Eun, So Yeon Kim, Wonhyo Seo, Jong-Min Jeong, Won-Mook Choi, Myung-Ho Ji Hoon Keun-Gyu Park, and Won-Il Jeong. Mol. Cells 2015;38:998-1006. https://doi.org/10.14348/molcells.2015.0218
CD11c is a dendritic cell marker in humans, which potentially induces cytotoxic effect on lymphoma cells. Forkhead boxP3 (FOXP3) regulator of T lymphocyte the microenvironment lymphoma. The principal objective this study was to determine whether tumors' expressions and FOXP3 are predictive clinical outcomes diffuse large B-cell (DLBCL) patients receiving treatment with rituximab, cyclophosphamide, anthracycline, vincristine, prednisone (R-CHOP) combination chemotherapy. population consisted...