A5049902585- Synthetic Organic Chemistry Methods
- Genomics and Phylogenetic Studies
- Asymmetric Synthesis and Catalysis
- Magnolia and Illicium research
- Chemical Synthesis and Analysis
- Advanced Synthetic Organic Chemistry
- Synthesis and biological activity
- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Evaluation
- Skin Protection and Aging
- Microbial Community Ecology and Physiology
- Synthesis of Organic Compounds
- Oxidative Organic Chemistry Reactions
- Cancer therapeutics and mechanisms
- Chemical synthesis and alkaloids
- Cytokine Signaling Pathways and Interactions
- Plant Disease Resistance and Genetics
- Synthesis and Catalytic Reactions
- melanin and skin pigmentation
- Plant Pathogenic Bacteria Studies
- Ginseng Biological Effects and Applications
- Catalytic C–H Functionalization Methods
Chungbuk National University
2016-2025
Seoul National University Hospital
2018-2022
Seoul National University
2005-2021
Emory University
2014-2021
Kyung Hee University
2010-2020
Cheongju University
2019-2020
Government of the Republic of Korea
2019-2020
Bio-Medical Science (South Korea)
2018-2019
Hanyang University
2006-2018
Ewha Womans University
2017
A convergent diastereo- and enantioselective total synthesis of anti-HIV agent chloropeptin I is reported. Important features the include: (1) use Ti-catalyzed cyanide addition to imines prepare a requisite amino acid moiety, (2) discovery positive effect MeOH in Cu-mediated biaryl ether formation afford one two macrocyclic peptide moieties, (3) influence collidine diastereoselective Pd-mediated cross-coupling result efficient another macrocycle within this medicinally important molecule....
Piperlongumine has anti-cancer activity in numerous cancer cell lines via various signaling pathways. But there been no study regarding the mechanisms of PL on lung yet. Thus, we evaluated effects and possible non-small (NSCLC) cells vivo vitro. Our findings showed that induced apoptotic death suppressed DNA binding NF-κB a concentration dependent manner (0-15 μM) NSCLC cells. Docking model pull down assay directly binds to site nuclear factor-κB (NF-κB) p50 subunit, surface plasmon...
Alzheimer's disease, which is pathologically characterized by an excessive accumulation of amyloid beta (Aβ) fibrils, a degenerative brain disease and the most common cause dementia. In previous study, it was reported that increased level CHI3L1 in plasma found AD patients. We investigated inhibitory effect 2-({3-[2-(1-cyclohexen-1-yl)ethyl]-6,7-dimethoxy-4-oxo-3,4-dihydro-2-quinazolinyl}sulfanyl)-N-(4-ethylphenyl)butanamide (K284-6111), inhibitor chitinase 3 like 1 (CHI3L1), on memory impairment Aβ
Organocatalysts are abundantly used for various transformations, particularly to obtain highly enantio- and diastereomeric pure products by controlling the stereochemistry. These applications of organocatalysts have been topic several reviews. emerged as one very essential areas research due their mild reaction conditions, cost-effective nature, non-toxicity, environmentally benign approach that obviates need transition metal catalysts other toxic reagents. Various types including amine...
Neuroinflammation is implicated for amyloidogenesis. Sulfur compounds extracted from garlic have been shown to anti-inflammatory properties. Previously, we investigated that thiacremonone, a sulfur compound isolated has anti-inf
Abstract Mice lacking the IL-1R–associated kinase 4 (IRAK4) are completely resistant to LPS-induced endotoxic disorder or TLR9 agonist CpG DNA plus d-galactosamine–induced acute liver injury (ALI), whereas wild-type strains succumb. However, translational drugs against sepsis ALI remain elusive. Lonicerae flos extract is undergoing clinical trial phase I in LPS-injected healthy human volunteers for treatment. In current study, chlorogenic acid (CGA), a major anti-inflammatory constituent of...
Rationale: Chitinase 3-like 1 (Chi3L1) protein is up-regulated in various diseases including solid cancers. According to Genome-Wide Association Study (GWAS)/Online Mendelian Inheritance Man (OMIM)/Differentially Expressed Gene (DEG) analyses, Chi3L1 associated with 38 cancers, and more highly cancer compared other oncogenes such as EGFR, TNFα, etc. However, the mechanisms pathways by which are not clear. In current study, we investigated role of lung metastasis. Methods: We performed...
Eleven novel isoquinoline-1-carboxamides (HSR1101~1111) were synthesized and evaluated for their effects on lipopolysaccharide (LPS)-induced production of pro-inflammatory mediators cell migration in BV2 microglial cells. Three compounds (HSR1101~1103) exhibited the most potent suppression LPS-induced mediators, including interleukin (IL)-6, tumor necrosis factor-alpha, nitric oxide (NO), without significant cytotoxicity. Among them, only N-(2-hydroxyphenyl) isoquinoline-1-carboxamide...
Our previous big data analyses showed a high level of association between chitinase 3 like1 (CHI3L1) expression and lung tumor development. In the present study, we investigated whether CHI3L1‐inhibiting chemical, 2‐({3‐[2‐(1‐cyclohexen‐1‐yl)ethyl]‐6,7‐dimethoxy‐4‐oxo‐3,4‐dihydro‐2‐quinazolinyl}sulfanyl)‐N‐(4‐ethylphenyl)butanamide (K284), could inhibit metastasis studied its mechanism action. We antitumor effect K284 both in vitro vivo . (0.5 mg·kg −1 body weight) significantly inhibited...
Background: Melanocortin 1 receptor (MC1R), a of α-melanocyte-stimulating hormone (α-MSH), is exclusively present in melanocytes where α-MSH/MC1R stimulate melanin pigmentation through microphthalmia-associated transcription factor M (MITF-M).Toll-like 4 (TLR4), endotoxin lipopolysaccharide (LPS), distributed immune and other cell types including LPS/TLR4 activate transcriptional activity nuclear (NF)-κB to express cytokines innate immunity.LPS/TLR4 also up-regulate MITF-M-target melanogenic...