A5101718713- Pharmacological Effects of Natural Compounds
- Drug Transport and Resistance Mechanisms
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Cancer, Hypoxia, and Metabolism
- Magnolia and Illicium research
- Eicosanoids and Hypertension Pharmacology
- Immune Cell Function and Interaction
- Animal Genetics and Reproduction
- Bioactive Compounds and Antitumor Agents
- CRISPR and Genetic Engineering
- Dermatology and Skin Diseases
- NF-κB Signaling Pathways
- Biochemical Analysis and Sensing Techniques
- Pharmacogenetics and Drug Metabolism
- Allergic Rhinitis and Sensitization
- melanin and skin pigmentation
- Oxidative Organic Chemistry Reactions
- Metabolomics and Mass Spectrometry Studies
- interferon and immune responses
- Cancer therapeutics and mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Ginseng Biological Effects and Applications
- Silymarin and Mushroom Poisoning
- Histone Deacetylase Inhibitors Research
University of Missouri
2013-2024
Korea University
2015-2024
Sejong University
2013-2024
Korea University Medical Center
2017-2022
Virginia Tech
2015-2021
Brown University
2013-2020
Rhode Island Hospital
2013-2020
National Development Institute of Korean Medicine
2019-2020
Sejong Institute
2019-2020
Government of the Republic of Korea
2019-2020
Significance There is a critical lack of therapeutic agents to treat infections caused by nongrowing persister forms methicillin-resistant Staphylococcus aureus (MRSA). Although membrane-disrupting can kill cells, their potential has been mostly overlooked because low selectivity for bacterial versus mammalian membranes. We report that the clinically approved anthelmintic drug bithionol kills MRSA persisters disrupting membrane lipid bilayers at concentrations exhibit levels toxicity cells....
Abstract Background Neuroinflammation is important in the pathogenesis and progression of Alzheimer disease (AD). Previously, we demonstrated that lipopolysaccharide (LPS)-induced neuroinflammation caused memory impairments. In present study, investigated possible preventive effects 4- O -methylhonokiol, a constituent Magnolia officinalis , on deficiency by LPS, along with underlying mechanisms. Methods We whether -methylhonokiol (0.5 1 mg/kg 0.05% ethanol) prevents dysfunction...
Adjusting to a continuously changing environment is key feature of life. For metazoans, environmental changes include alterations in the gut microbiota, which can affect both memory and behavior. The bacteriovorous nematode Caenorhabditis elegans discriminates between pathogenic non-pathogenic food sources, avoiding consumption pathogens. Here, we demonstrate role intestine regulating C. avoidance Pseudomonas aeruginosa by an insulin-like neuropeptide encoded ins-11. transcriptional...
Abstract Application of genetically engineered (GE) large animals carrying multi-allelic modifications has been hampered by low efficiency in production and extended gestation period compared to rodents. Here, we rapidly generated RAG2 / IL2RG double knockout pigs using direct injection CRISPR/Cas9 system into developing embryos. RAG2/IL2RG deficient were immunodeficient, characterized depletion lymphocytes either absence or structurally abnormal immune organs. Pigs maintained gnotobiotic...
HIF-1 is associated with poor prognoses and therapeutic resistance in cancer patients. We previously developed a novel hypoxia-inducible factor (HIF)-1 inhibitor, IDF-11774, clinical candidate for therapy. also reported that IDF-1174 inhibited HSP70 chaperone activity suppressed accumulation of HIF-1α. In this study, IDF-11774 the HIF-1α vitro vivo colorectal carcinoma HCT116 cells under hypoxic conditions. Moreover, treatment angiogenesis by reducing expression target genes, reduced glucose...
Due to their profound antiproliferative activity and unique mode of action, phenanthroindolizidine phenanthroquinolizidine alkaloids, represented by antofine cryptopleurine, have attracted attention recently as potential therapeutic agents. We designed, synthesized, evaluated the methanesulfonamide analogues these natural alkaloids with hope improving druglikeness. The showed enhanced growth inhibition human cancer cells compared parent products. In particular, a analogue cryptopleurine (5b)...
Eye diseases characterized by excessive angiogenesis such as wet age-related macular degeneration, proliferative diabetic retinopathy, and retinopathy of prematurity are major causes blindness. Cremastranone is an antiangiogenic, naturally occurring homoisoflavanone with efficacy in retinal choroidal neovascularization models antiproliferative selectivity for endothelial cells over other cell types. We undertook a cell-based structure-activity relationship study to develop more potent...
Magnolia bark contains several compounds such as magnolol, honokiol, 4‐ O ‐methylhonokiol, obovatol, and other neolignan compounds. These have been reported to various beneficial effects in diseases. There is sufficient possibility that ethanol extract of officinalis more effective amyloidogenesis via synergism these ingredients. Neuroinflammation has known play a critical role the pathogenesis Alzheimer's disease (AD). We investigated whether M. (10 mg/ kg 0.05% ethanol) prevents memory...
Biologically important quinazolinones have been synthesized from 2-aminobenzamides and DMSO.
Solvent-directed intramolecular hydrofunctionalization of readily available o -alkynoylphenols 1 was successfully achieved under reagent-free conditions.
Generating porcine embryos in vitro is a critical process for creating genetically modified pigs as agricultural and biomedical models; however, these embryo technologies have been scarcely applied by the swine industry. Currently, primary issue with -produced low pregnancy rate after transfer small litter size, which may be exasperated micromanipulation procedures. Thus, this review, we discuss improvements that made to production system increase number of live piglets per well...
(<i>R</i>)-4-(3,4-Dihydro-8,8-dimethyl)-2<i>H</i>,8<i>H</i>-benzo[1,2-<i>b</i>:3,4-<i>b</i>′] dipyran-3yl)-1,3-benzenediol (glabridin) is known to have anti-inflammatory, antimicrobial, and cardiovascular protective activities. In the present study, we report inhibitory effect of glabridin on intercellular adhesion molecule-1 (ICAM-1) expression in tumor necrosis factor-α (TNF-α)-stimulated human umbilical vein endothelial cells (HUVECs). Glabridin inhibited THP-1 cell HUVECs stimulated by...
The present study reports the antiinflammatory activity of a methanol extract isolated from stem bark Magnolia kobus (MK). MK potently inhibited lipopolysaccharide (LPS)-induced production nitric oxide and interleukin-1beta (IL-1beta) in RAW 264.7 cells, murine macrophage-like cell line. secretion tumor necrosis factor-alpha (TNF-alpha) was also suppressed LPS-stimulated cells although magnitude inhibition weaker than that IL-1beta. mRNA expressions inducible synthase (iNOS), IL-1beta...
Hydroxamate-based HDAC inhibitors have promising anticancer activities but metabolic instability and poor pharmacokinetics leading to in vivo results. QSAR PK studies of showed that a γ-lactam core modified cap group, including halo, alkyl, alkoxy groups with various carbon chain linkers, improved inhibition stability. The biological properties the were evaluated; compound designated 8f had potent activity high oral bioavailability.
Drug-induced liver injury (DILI) via metabolic activation by drug-metabolizing enzymes, especially cytochrome P450 (CYP), is a major cause of drug failure and withdrawal. In this study, an in vitro model using HepG2 cells combination with human microsomes was developed for the prediction DILI. The cytotoxicity cyclophosphamide, bioactivation, augmented cultured manner dependent on exposure time, microsomal protein concentration, NADPH. Experiments pan- or isoform-selective CYP inhibitors...
1,2,3,4-Tetrahydroquinolines have been identified as the most potent inhibitors of LPS-induced NF-κB transcriptional activity. To discover new molecules this class with excellent activities, we designed and synthesized a series novel derivatives 1,2,3,4-tetrahydroquinolines (4a-g, 5a-h, 6a-h, 7a-h) bioevaluated their in vitro activity against human cancer cell lines (NCI-H23, ACHN, MDA-MB-231, PC-3, NUGC-3, HCT 15). Among all scaffolds, 6g exhibited inhibition (53 times that reference...