A5018778492- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Neuropeptides and Animal Physiology
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Diabetes Treatment and Management
- Mesenchymal stem cell research
- Nerve injury and regeneration
- T-cell and B-cell Immunology
- Anomaly Detection Techniques and Applications
- Immunotherapy and Immune Responses
- Cholinesterase and Neurodegenerative Diseases
- Periodontal Regeneration and Treatments
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Wound Healing and Treatments
- Advanced Nanomaterials in Catalysis
- Opportunistic and Delay-Tolerant Networks
- Extracellular vesicles in disease
- Protein Kinase Regulation and GTPase Signaling
- Semiconductor Lasers and Optical Devices
- Phosphodiesterase function and regulation
- Melanoma and MAPK Pathways
- Human Pose and Action Recognition
- Renin-Angiotensin System Studies
Korea University of Science and Technology
2024
Korea Institute of Machinery and Materials
2024
Soongsil University
2008
Korea Innotech (South Korea)
2007
University of Oxford
2005
NHS Blood and Transplant
2005
Littlemore Hospital
2003
University of Leeds
1995-2000
Institute of Structural and Molecular Biology
2000
Stanford University
1999
Splicing variants of type 4 phosphodiesterases (PDE4) are regulated by phosphorylation. In these proteins, a conserved region is located between the amino-terminal domain, which target for phosphorylation, and catalytic domain. Previous studies have indicated that nested deletions encompassing this cause an increase in activity, suggesting domain exerts inhibitory constraint on catalysis. Here, we further investigated presence function A time-dependent hydrolytic activity was observed when...
Charcot-Marie-Tooth disease (CMT) is a hereditary with heterogeneous phenotypes and genetic causes. CMT type 1A (CMT1A) of affecting the peripheral nerves caused by duplication myelin protein 22 (PMP22) gene. Human tonsil-derived mesenchymal stem cells (TMSCs) are useful for cell therapy in various diseases can be differentiated into Schwann cell-like (TMSC-SCs). We investigated potential TMSC-SCs called neuronal regeneration-promoting (NRPCs) nerve muscle regeneration C22 mice, model CMT1A....
A synthetic peptide derived from vaccinia virus growth factor (VGF) was used as an immunogen to prepare antiserum able immunoprecipitate native VGF both virus-infected cell lysate and cell-free medium. Pulse-chase, tunicamycin treatment, carbohydrate trimming experiments revealed that is synthesized a 19-kilodalton (kDa) precursor which rapidly modified high-mannose-type 22-kDa protein. This cell-associated form further processed into 25-kDa polypeptide which, after proteolytic cleavage,...
One of the major goals Chromosome-Centric Human Proteome Project (C-HPP) is to fill knowledge gaps between human genomic information and corresponding proteomic information. These are due "missing" proteins (MPs)-predicted with insufficient evidence from mass spectrometry (MS), biochemical, structural, or antibody analyses-that currently account for 2579 19587 predicted (neXtProt, 2017-01). We address some lessons learned inconsistent annotations missing in databases (DB) demonstrate a...
The membrane-bound form of mammalian aminopeptidase P (AP-P; EC 3.4. 11.9) is a mono-zinc-containing enzyme that lacks any the typical metal binding motifs found in other zinc metalloproteases. To identify residues involved and catalysis, sequence structural information was used to align porcine AP-P with members peptidase clan MG, including Escherichia coli methionyl aminopeptidases. Residues predicted be critical for activity were mutated resultant proteins expressed COS-1 cells....
Aminopeptidase P (AP‐P), purified to homogeneity from porcine kidney membranes, was completely inactivated by treatment with 0.2 mM diethylpyrocarbonate (DEP) at pH 7.0. Treatment of the modified enzyme 20 hydroxylamine resulted in recovery AP‐P activity. The differential absorption native and 240 nm showed that DEP two histidyl residues per mol AP‐P. substrates, bradykinin(1–5) Gly‐Pro‐Hyp, also inhibitor, apstatin, could protect against inactivation. These results suggest histidine are critical for
The ESCAPE multicentre survey was designed to (a) compare the agreement of three relevant aesthetic scoring systems among different centres, and (b) evaluate reproducibility each question questionnaires.EFP centres (n = 14) were involved in an e-survey. Forty-two participants (28 teachers, 14 postgraduate students) asked score one-year outcomes photographs using Before-After Scoring System (BASS), Pink Esthetic Score (PES) Root coverage (RES). Mean values kappa statistics performed on...
In general, the nerve cells of peripheral nervous system regenerate normally within a certain period after physical damage their axon. However, when nerves are transected by trauma or tissue extraction for cancer treatment, spontaneous regeneration cannot occur. Therefore, it is necessary to perform microsurgery connect directly insert conduit it. this study, we applied human tonsillar mesenchymal stem cell (TMSC)-derived Schwann cell-like (TMSC-SCs) facilitate and prevent muscle atrophy...
The scheme proposed in this thesis organizes dynamically clusters at the time of events occurrence and maintains them. other side, existing cluster based USN (ubiquitous sensor networks) organize network initial a lump. So method causes much energy exhaustion. Therefore can be more efficient than one aspect usage gathering sending data. In order to efficiently process various events, divides when occurred area which organized in. another case, it merges same event occurs different near...
A well-designed strong-weak augmentation strategy and the stable teacher to generate reliable pseudo labels are essential in teacher-student framework of semi-supervised learning (SSL). Considering these mind, suit human pose estimation (SSHPE) task, we propose a novel approach referred as Pose-MUM that modifies Mix/UnMix (MUM) augmentation. Like MUM dense prediction proposed makes for leads network learn relationship between each key point much better than conventional methods by adding...
Active Learning (AL) and Semi-supervised are two techniques that have been studied to reduce the high cost of deep learning by using a small amount labeled data large unlabeled data. To improve accuracy models at lower cost, we propose method called (ASSL), which combines AL SSL. maximize synergy between SSL, focused on differences ASSL AL. involves more dynamic model updates than due use in training process, resulting temporal instability predicted probabilities This makes it difficult...