A5046876658- Histone Deacetylase Inhibitors Research
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Pharmacological Effects of Natural Compounds
- Protein Degradation and Inhibitors
- Synthetic Organic Chemistry Methods
- Fungal Biology and Applications
- Natural product bioactivities and synthesis
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Cytokine Signaling Pathways and Interactions
- Quinazolinone synthesis and applications
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Ginseng Biological Effects and Applications
- Immune cells in cancer
- Click Chemistry and Applications
Korea Research Institute of Bioscience and Biotechnology
2016-2025
First Hospital of China Medical University
2018
China Medical University
2018
Chungbuk National University
2014-2017
Korea Institute of S&T Evaluation and Planning
2013
Korea Institute of Ocean Science and Technology
2012
University of Ulsan
2011
Asan Medical Center
2011
Ulsan College
2011
Korea Advanced Institute of Science and Technology
1999-2007
Leucyl-tRNA synthetase (LRS) is known to function as leucine sensor in the mammalian target of rapamycin complex 1 (mTORC1) pathway. However, pathophysiological significance its activity not well understood. Here, we demonstrate that for mTORC1 activation LRS can be decoupled from catalytic activity. We identified compounds inhibit leucine-dependent pathway by specifically inhibiting GTPase activating LRS, while affecting For further analysis, selected one compound, BC-LI-0186, which binds...
Even low-intensity blue light emitted by display devices exerts hazardous effects on RPE cells, which might be solved if contain less short wavelength light.
Significance LRS, an enzyme involved in protein synthesis, and Sestrin2, a stress-induced metabolic protein, are suggested to function as leucine sensors for the mTORC1 pathway, central regulator of cell metabolism, growth, proliferation, survival. The Rag GTPase cycle regulates mTORC1; however, regulators their coordination remain unknown. We show dynamics RagD–RagB during signaling describe contrasting yet complementary roles LRS Sestrin2 GTPase–mTORC1 functioning “ON” “OFF” switches,...
Cancer stem cells (CSCs) contribute to the resistance of intractable prostate cancer, and dopamine receptor (DR)D2 antagonists exhibit anticancer activity against cancer CSCs. Human PC-3 were used generate CSC-like cells, serving as a surrogate system identify specific DR subtype inhibition which significantly affects prostate-derived Additionally, present study aimed determine downstream signaling molecules this that exert more profound effects compared with other subtypes. The inhibitory...
Silymarin, a polyphenolic flavonoid antioxidant, is known to have anti-inflammatory, hepatoprotective, and anticarcinogenic effects. In the present study, we report inhibitory effect of silymarin on nitric oxide production inducible nitric-oxide synthase (iNOS) gene expression in macrophages. vivo administration attenuated by peritoneal macrophages lipopolysaccharide (LPS)-treated mice. Silymarin also dose dependently suppressed LPS-induced isolated mouse RAW 264.7, murine macrophage-like...
Here, we investigated whether titanium dioxide (TiO2) nanoparticles affect in vivo tumor growth through the modulation of mononuclear leukocytes. In vitro lymphocyte proliferation by lipopolysaccharide (LPS) or concanavalin A (ConA) was reduced < 25 nm TiO2 with a dose-dependent manner. Similarly, inhibited nitric oxide (NO) production from bone marrow-derived macrophages obtained naïve mice. When mice were intraperitoneally (IP) injected 100 once day for 7 days, total cell number...
Five new sesterterpenes, 14,15-dehydro-6-epi-ophiobolin K (1), 14,15-dehydro- ophiobolin (2), G (3), 14,15-dehydro-ophiobolin (4) and 14,15-dehydro-(Z)-14-ophiobolin (5), together with four known ophiobolins (6-9) were isolated from the marine fungus Aspergillus flocculosus derived seaweed Padina sp. collected in Vietnam. The five first as derivatives consisting of a fully unsaturated side chain. Their structures elucidated via spectroscopic methods including 1D, 2D NMR HR-ESIMS. absolute...
(<i>R</i>)-4-(3,4-Dihydro-8,8-dimethyl)-2<i>H</i>,8<i>H</i>-benzo[1,2-<i>b</i>:3,4-<i>b</i>′]dipyran-3yl)-1,3-benzenediol (glabridin), a flavonoid present in licorice extract, is known to have antimicrobial, anti-inflammatory, and cardiovascular protective activities. In the study, we report inhibitory effect of glabridin on nitric oxide (NO) production inducible (iNOS) gene expression murine macrophages. Glabridin attenuated lipopolysaccharide (LPS)-induced NO isolated mouse peritoneal...
In light of the anti-inflammatory properties histone deacetylase (HDAC) inhibitors, such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA), we examined a new HDAC inhibitor KBH-A42 for its activities. showed noteworthy in vitro via suppression production TNF-α, proinflammatory cytokine, nitric oxide (NO), effector molecule, LPS-stimulated RAW264.7 cells peritoneal macrophages. It also inhibited TNF-α vivo demonstrated LPS-induced mouse endotoxemia model. The levels IL-1β,...