A5088152116- Selenium in Biological Systems
- Trace Elements in Health
- Sperm and Testicular Function
- Effects and risks of endocrine disrupting chemicals
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Birth, Development, and Health
- Estrogen and related hormone effects
- Iron Metabolism and Disorders
- Anesthesia and Neurotoxicity Research
- Hair Growth and Disorders
- Reproductive System and Pregnancy
- Biochemical effects in animals
- Healthcare and Venom Research
- Nanoparticles: synthesis and applications
- Magnolia and Illicium research
- Phytoestrogen effects and research
- Pregnancy and preeclampsia studies
- Heavy Metal Exposure and Toxicity
- Fatty Acid Research and Health
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Digestive system and related health
- Reproductive Biology and Fertility
- Neuroscience and Neuropharmacology Research
Chungbuk National University
2015-2024
National University College
2019-2020
New Generation University College
2019-2020
Cheongju University
2015
Jeonju University
2006-2015
Chungnam National University Hospital
2005-2007
Konyang University Hospital
2005
Daejeon University
2005
The University of Tokyo
1997-2000
Seoul National University
2000
Abstract Background Neuroinflammation is important in the pathogenesis and progression of Alzheimer disease (AD). Previously, we demonstrated that lipopolysaccharide (LPS)-induced neuroinflammation caused memory impairments. In present study, investigated possible preventive effects 4- O -methylhonokiol, a constituent Magnolia officinalis , on deficiency by LPS, along with underlying mechanisms. Methods We whether -methylhonokiol (0.5 1 mg/kg 0.05% ethanol) prevents dysfunction...
Abstract It has previously been reported that Th1 CD4 T cell populations can be converted to IL-4 producers, whereas Th2 are refractory IL-12-mediated IFN-gamma production. We have recently shown CD30 is a marker for the response and therefore used here study commitment. show normally stable phenotype fail respond IL-12 because of endogenous abrogates this antagonistic effect permits conversion producers by IL-12. In complete absence IL-4, however, not required transformation, cells...
Abstract Prior studies have implicated CD30 as a marker for Th2 cells, but the mechanism that underlies this correlation was unknown. We show here expressed on activated CD4+ T cells in presence of IL-4. In absence endogenously produced IL-4, however, even lineage lost expression. Thus, is not an intrinsic inducible by also found to be down-regulated IFN-gamma. Committed Th1 effector do express CD30, although differentiating temporarily CD30. The transient expression mainly result IL-4...
Magnolol, honokiol, and obovatol are well-known bioactive constituents of the bark Magnolia officinalis have been used as traditional Chinese medicines for treatment neurosis, anxiety, stroke. We recently isolated novel active compound (named 4-O-methylhonokiol) from ethanol extract officinalis. The present study aimed to test two different doses extracts (5 10 mg/kg/mouse, p.o., 1 week) 4-O-methylhonokiol (0.75 1.5 administered 7 days on memory impairment induced by scopolamine (1 mg/kg...
Titanium dioxide (TiO2) nanoparticles are among the most manufactured nanomaterials in industry, and used food products, toothpastes, cosmetics paints. Pregnant women as well their conceptuses may be exposed to TiO2 nanoparticles; however, potential effects of these during pregnancy controversial, internal distribution has not been investigated. Therefore, this study, we investigated oral exposure pregnancy. were orally administered pregnant Sprague-Dawley rats (12 females per group) from...
Murine CD30 cDNA predicts a protein of 498 amino acids with homology to the TNF receptor family proteins characterized by repeated cysteine-rich motifs in extracellular domain. CD30, although homologous human has 90 acid gap an region that appears be duplicated CD30. was shown functional through production soluble murine Ig fusion (CD30-Ig) active binding cells expressed ligand. CD30-Ig also served as immunogen for hamster anti-mouse mAbs, which recognized both lymphocytes and transfected...
Abstract Proper placental development in early pregnancy ensures a positive outcome later on. The developmental relationship between the placenta and embryonic organs, such as heart, is crucial for normal pregnancy. However, mechanism through which influences of organs remains unclear. Trophoblasts fuse to form multinucleated syncytiotrophoblasts (SynT), primarily make up materno-fetal interface. We discovered that endogenous progesterone immunomodulatory binding factor 1 (PIBF1) vital...
To examine a potential role for soybean phytoestrogens in postmenopausal bone loss, twenty-four 12-week-old Sprague-Dawley rats were divided randomly into 4 groups and given controlled diets 16 weeks. The treatment as followed: sham operated, ovariectomized (OVX) control, OVX + isoflavone extract (6.25 g/kg), 17β-estradiol (4 mg/kg). treatments reduced femoral fourth lumbar vertebral density mineral content (p<0.01), decreased uterine weight accelerated body increases (p<0.05), increased the...
Myeloid differentiation 2 (MD-2) recognizes endotoxin lipopolysaccharide (LPS), which is required for Toll-like receptor 4 (TLR4) activity. MD-2 represents a more attractive therapeutic target than TLR4 intervention in severe inflammatory disorders due to microbial infection. Here, we suggest as molecular of nonlipid chalcone the inhibition LPS-induced cellular inflammation. A derivative, 2′,4-dihydroxy-6′-isopentyloxychalcone (JSH) competitively displaced LPS from MD-2, and was fitted into...
Curcumin significantly improves testicular injuries (B & C) induced by scrotal heat stress in a dose-dependent manner (20, 40, and 80 mg kg<sup>−1</sup>; D–F, respectively).
Abstract The rat is a time-honored traditional experimental model animal, but its use limited due to the difficulty of genetic modification. Although engineered endonucleases enable us manipulate genome, it not known whether newly identified endonuclease Cpf1 system applicable rats. Here we report first application CRISPR-Cpf1 in rats and investigate Apoe knockout can be used as an atherosclerosis model. We generated Apoe- and/or Ldlr -deficient via system, characterized by high efficiency,...
Cerium oxide nanoparticles (CeO2 NPs) are widely used in various commercial applications because of their characteristic properties. People can be easily exposed to CeO2 NPs real life, but the safety assessment has not been fully investigated. Therefore, this study, we conducted a combined repeated-dose and reproductive/developmental toxicity screening study (OECD testing guideline 422) investigate potential hazards on human health, including functions, after repeated daily oral gavage...
Bisphenol A (BPA), a ubiquitous environmental contaminant, has been shown to cause developmental toxicity and carcinogenic effects. BPA may have physiological activity through estrogen receptor (ER) -alpha -beta, which are expressed in the central nervous system. We previously found that exposure of immature mice resulted behavioral alternation, suggesting overexposure could be neurotoxic. In this study, we further investigated molecular neurotoxic mechanisms BPA. increased vulnerability...
This study was performed to examine whether capsaicin, the main pungent ingredient of red peppers, exerts protective effects against testicular injuries induced by transient scrotal hyperthermia. Capsaicin (0.33 mg kg-1 ) administered subcutaneously mice one hour before heat stress (HS) in a 43°C water bath for 20 min. After 7 days, exposed HS showed low weight, severe vacuolisation seminiferous tubules followed loss spermatogenic cells, and appearance multinucleated giant cells remarkable...