A5049567111- Glycosylation and Glycoproteins Research
- Pancreatic function and diabetes
- Drug-Induced Hepatotoxicity and Protection
- Organic Electronics and Photovoltaics
- Caveolin-1 and cellular processes
- Nanofabrication and Lithography Techniques
- Xenotransplantation and immune response
- Neuroblastoma Research and Treatments
- Advanced Manufacturing and Logistics Optimization
- Axon Guidance and Neuronal Signaling
- Nanomaterials and Printing Technologies
- Engineering Applied Research
- Liver physiology and pathology
- Toxin Mechanisms and Immunotoxins
- Proteoglycans and glycosaminoglycans research
- Fluid Dynamics and Thin Films
- Optimization and Packing Problems
- Diabetes and associated disorders
- Thin-Film Transistor Technologies
- Nephrotoxicity and Medicinal Plants
- Peroxisome Proliferator-Activated Receptors
- Signaling Pathways in Disease
- Mesenchymal stem cell research
- ATP Synthase and ATPases Research
- Lipid metabolism and disorders
Wonkwang University
2006-2023
Seoul National University
2020-2022
Yeungnam University
2019
Korea Institute of Oriental Medicine
2011-2013
Chungbuk National University
2007-2010
Institute for Basic Science
2003
Washington State University
2003
Kyungpook National University Hospital
2001
Abstract BACKGROUND Bee venom has been used as a traditional medicine to treat arthritis, rheumatism, back pain, cancerous tumors, and skin diseases. However, the effects of bee on prostate cancer their action mechanisms have not reported yet. METHODS T o determine effect its major component, melittin cells, apoptosis is analyzed by tunnel assay apoptotic gene expression. For xenograft studies, was administrated intraperitoneally twice per week for 4 weeks, tumor growth measured were...
Stem cells are used for the investigation of developmental processes at both cellular and organism levels offer tremendous potentials clinical applications as an unlimited source transplantation. Gangliosides, sialic acid-conjugated glycosphingolipids, play important regulatory roles in cell proliferation differentiation. However, their expression patterns stem during neuronal differentiation not known. Here, we investigated gangliosides growth mouse embryonic (mESCs), mesenchymal (MSCs)...
In this study, we investigated the regulatory role of ganglioside GD1a in differentiation osteoblasts from human mesenchymal stem cells (hMSCs) by using lentivirus‐containing short hairpin (sh)RNA to knockdown ST3 β‐galactoside α‐2, 3‐sialyltransferase 2 (ST3Gal II) mRNA expression. After hMSCs were infected for 72 h with lentivirus constructed ST3Gal II shRNAs, puromycin‐resistant selected and subcultured produce knockdown. The established dental papilla abundantly expressed CD44 CD105, but...
Aristolochia manshuriensis Kom (AMK) is a traditional medicinal herb used for the treatment of arthritis, rheumatism, hepatitis, and anti-obesity. Because nephrotoxicity carcinogenicity AMK, there are no pharmacological reports on anti-obesity potential AMK. Here, we showed AMK has an inhibitory effect adipocyte differentiation 3T3-L1 cells along with significantly decrease in lipid accumulation by downregulating several adipocyte-specific transcription factors including peroxisome...
Hwangryunhaedok-tang (HRT) has been long used as traditional medicine in Asia. However, inhibitory role of HRT is unclear early stage 3T3-L1 adipocyte differentiation related to signaling. In the present study, we investigated effects on upstream signaling peroxisome proliferation-activity receptor- γ (PPAR- ) and CCAAT/enhancer binding protein- β (C/EBP- expression preadipocytes. We found that significantly inhibited by downregulating several adipocyte-specific transcription factors...
The human colorectal carcinoma-associated GA733 antigen epithelial cell adhesion molecule (EpCAM) was initially described as a surface protein selectively expressed in some myeloid cancers. Gangliosides are sialic acid-containing glycosphingolipids involved inflammation and oncogenesis. We have demonstrated that treatment with anti-EpCAM mAb RAW264.7 cells significant inhibited the growth SW620 cancer cells, but neither nor alone induced cytotoxicity. relationship between ganglioside...
Lumbar facet joint osteoarthritis (FJOA) caused by degenerative change(s) is considered to be the main cause of joint-origin low back pain (LBP). Intra-articular lumbar (IA LFJ) corticosteroid injection widely used for controlling induced FJOA. In current study, outcomes IA LFJ were evaluated according severity A total 50 patients who received injections treatment recruited. Patients classified into three groups FJOA, which was indicated during a axial MRI. 10 assigned group (patients with...
Expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) is mainly found in the Leydig cells from which steroid hormones are biosynthesized testes. To investigate whether endocrine disruptors affect microenvironment testes, mRNA expression 3beta-HSD as a molecular marker for androgen biosynthesis was analyzed rat testes exposed to several using reverse transcription-polymerase chain reaction technique. Testosterone [50, 200 and 1,000 microg/kg body weight (BW)], flutamide (1, 5 25 mg/kg...
Arisolochiae species plants containing aristolochic acids I and II (AA AA II) are well known to cause acid nephropathy (AAN). Recently, there various approaches use AAs-containing herbs after the removal of their toxic factors. However, is little information about genotoxicity manshuriensis Kom. (AMK) per se . To obtain safety for AMK, its was evaluated in accordance with OECD guideline. evaluate we tested bacterial reverse mutation assay, chromosomal aberration test, micronucleus test....
Neuronal damage subsequent to transient cerebral ischemia is a multifactorial process involving several overlapping mechanisms. Gangliosides, sialic acidconjugated glycosphingolipids, reduce the severity of acute brain in vitro. However their vivo effects on cortex damaged by ischemic infarct are unknown. To assess possible protective role gangliosides we examined expression rat. Ischemia was induced middle artery (MCA) occlusion, and resulting observed staining with 2, 3,...
Aristolochic acid (AA) is a natural bioactive substance found in Chinese herbs that induce toxicity during ovarian maturation of animals and humans. Apoptosis induced by various types damage governs the progression biological cell removal controls equilibrium between growth death. However, AA mechanism testis mouse has not been elucidated was thus focus present study. This study used TM4 Sertoli cells an ICR model, both which were injected with aristolochic I (AAI) for 4 weeks. Testis...
Aristolochic acids are natural products found in Chinese herbs of the Aristolochiaceae family. acid I (AAI) is a potent carcinogen and was to be toxic animal clinical studies. Apoptosis rapid, selective process physiological cell deletion that regulates balance between proliferation death induced by various kinds damage. However, toxicity AAI during ovarian maturation mouse unclear subject present investigation. We used hamster ovary-K1 (CHO-K1) cells an injection model: MTT assay assess AA...
Pregnancy is associated with reactivation of latent infections many protozoal and helminthic parasites. To facilitate in vivo studies on the process transmammary transmission hookworm infection to nursing newborns, we established an experimental model BALB/c mice infective larvae canine nematode Ancylostoma caninum. establish latency a significant reservoir tissue achieve acceptable pregnancy success rates, were subcutaneously infected at day 5 postimpregnation; similar larval distribution...