A5101517886- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis Viruses Studies and Epidemiology
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- HIV/AIDS drug development and treatment
- Viral gastroenteritis research and epidemiology
- Eosinophilic Esophagitis
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Biliary and Gastrointestinal Fistulas
- Gastroesophageal reflux and treatments
- Metastasis and carcinoma case studies
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Uterine Myomas and Treatments
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
Gachon University Gil Medical Center
2013-2025
Gachon University
2012-2025
Methodist Hospital
2024
Ajou University
2023
Samsung (South Korea)
2014-2022
Houston Methodist
2020
Deleted Institution
2009-2019
Kyungpook National University Hospital
2019
Anyang University
2018
Catholic University of Korea
2014-2016
To address a growing concern about drug-induced liver injury (DILI), nationwide study was performed to investigate the significance of DILI in Korea.From May 2005 2007, cases (alanine transferase > 3 × upper normal limit or total bilirubin 2 limit) from 17 referral university hospitals were prospectively enrolled. Adjudication by seven review boards considered for confirmation causality and Roussel Uclaf Causality Assessment Method (RUCAM) scale used.A 371 diagnosed with DILI. The...
Vasoactive drugs are recommended to be started as soon possible in suspected variceal bleeding, even before diagnostic endoscopy. However, it is still unclear whether the therapeutic efficacies of various vasoactive used comparable. The aim this prospective, multicenter, randomized, noninferiority trial was characterize effects terlipressin, somatostatin, and octreotide when they initiated endoscopic treatment patients with acute bleeding. Patients liver cirrhosis significant upper...
ARC-520, the first an RNA interference (RNAi) therapeutic, was designed to reduce all transcripts derived from covalently closed circular DNA, leading a reduction in viral antigens and hepatitis B virus (HBV) DNA.We aimed evaluate depth of surface antigen (HBsAg) decline response multiple doses ARC-520 compared placebo (PBO) two randomized, multicenter studies nucleoside/nucleotide analogue reverse-transcriptase inhibitor (NUC)-experienced patients with early (HBeAg)-negative (E-neg) or...
Clevudine is a pyrimidine analogue with potent and sustained antiviral activity against HBV. The present study evaluated the safety efficacy of 30 mg clevudine once daily for 24 weeks assessed durable response after cessation dosing. A total 243 hepatitis B e antigen (HBeAg)-positive chronic patients were randomized (3:1) to receive (n = 182) or placebo 61) weeks. Patients followed further off therapy. Median serum HBV DNA reductions from baseline at week 5.10 0.27 log10 copies/mL in groups,...
Clevudine is a pyrimidine analog with potent and sustained antiviral activity against HBV. In the present study, we evaluated safety efficacy of clevudine 30 mg daily for 24 weeks assessed durability response after cessation dosing in hepatitis B e antigen (HBeAg)-negative chronic (e-CHB). We randomized total 86 patients (3:1) to receive (n = 63) or placebo 23) weeks. followed an additional withdrawal treatment. The median changes HBV DNA from baseline were -4.25 -0.48 log(10) copies/mL at...
The emergence of infliximab was an epochal event in the treatment inflammatory bowel disease (IBD). Because colitis-associated cancers arose setting chronic inflammation, during which "inflammation-dysplasia-carcinoma sequence" prevails and anti-inflammatory agents can prevent carcinogenesis, we hypothesized whether colitic cancer animal models for C57BL/6 mice were exposed to 15 cycles dextran sulfate sodium (DSS), with each cycle consisting 0.7% DSS 1 week followed by sterilized water 10...
Abstract Background Although numerous chemotherapeutic agents have been tested, the role of systemic chemotherapy for hepatocellular carcinoma (HCC) has not clarified. New therapeutic strategies are thus needed to improve outcomes, and we designed this study with new effective drug combination. Methods Twenty-nine patients histologically-confirmed, metastatic HCC received a combination doxorubicin 60 mg/m 2 cisplatin on day 1, plus capecitabine 2000 /day as an intermittent regimen weeks...
Mutations of the epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) are important in pathogenesis lung cancer, recent reports have revealed racial geographical differences mutation expression.This study was conducted to investigate prevalence EGFR KRAS mutations their correlation with clinical variables Korean patients adenocarcinoma lung. Formalin-fixed specimens from 104 randomly selected diagnosed at Kosin University Gospel Hospital October 1996 January...
Besifovir dipivoxil maleate (BSV) has activity against hepatitis B virus (HBV). We performed a phase 3 study to compare the antiviral efficacy and safety of BSV vs tenofovir disoproxil fumarate (TDF) in patients with chronic HBV infection Korea.We conducted double-blind, non-inferiority trial 197 at 22 sites South Korea, from November 2013 through February 2016. Patients were randomly assigned groups given (150 mg, n = 99) or TDF (300 98) for 48 weeks. evaluated virologic responses therapy...
AIM:To investigate the roles of lymphocytes in development dextran sulfate sodium-induced colitis. METHODS:Using various doses sodium (DSS), we induced colitis wild-type B6 control and Rag-1 knockout (H-2 b haplotype) mice, evaluated terms symptomatic histologic parameters, such as weight loss, survival, severity diarrhea, shortage colon length histological changes.Symptomatic parameters were checked daily changes scored. RESULTS:Although mice treated with high dose (5%) DSS was comparable...
Abstract Colitis-associated cancers arise in the setting of chronic inflammation wherein an “inflammation-dysplasia-carcinoma” sequence prevails. Based on our previous findings which proton pump inhibitor could impose significant levels anti-inflammatory, antiangiogenic, and selective apoptosis induction beyond gastric acid suppression, we investigated whether omeprazole prevent development colitis-associated cancer a mouse model induced by repeated bouts colitis. Omeprazole, 10 mg/kg, was...
The incidence of colorectal cancer (CRC) is increasing, with metastasis newly diagnosed CRC reported in a large proportion patients. However, the effect Korean Red Ginseng extracts (KRGE) on epithelial to mesenchymal transition (EMT) unknown. Therefore, we examined mechanisms by which KRGE regulates EMT hypoxic conditions. Human cell lines HT29 and HCT116 were incubated under (1% oxygen) normoxic (21% Western blot analysis real-time PCR used evaluate expression markers presence KRGE....
As a rare liver disease, little is known about autoimmune hepatitis (AIH). This study investigated the clinical features and compared two diagnostic criteria of AIH in Korea.A nationwide, multicenter, retrospective analysis was done data adult patients diagnosed with from January 2005 to December 2009.The enrolled (n = 343; mean age, 52.8 years; range, 19-87 12% male, 88% female) met according revised original 311) or simplified 250). At diagnosis, 30.6% were asymptomatic, 22.7% cirrhotic,...
Clinical Features and Treatment Outcomes of Upper Gastrointestinal Bleeding in Patients with CirrhosisWith recent progress treatment modalities, mortality from upper gastrointestinal (UGI) bleeding has decreased appreciably.The aim this study was to establish how UGI bleeds are managed Korean patients cirrhosis evaluate outcomes.A total 479 episodes acute 464 were included during a six-month period at nine tertiary medical centers.Treatment outcomes assessed by failure control bleeding,...
We aimed to evaluate the efficacy and safety of peginterferon plus ribavirin for chronic hepatitis C (CHC) patients under real life setting in Korea.We retrospectively analyzed medical records 758 CHC treated with between 2000 2008 from 14 university hospitals Gyeonggi-Incheon area Korea.Hepatitis virus (HCV) genotype 1 was detected 61.2% patients, while 2 35.5%. Baseline HCV RNA level ≥6×10(5) IU/mL 51.6% patients. The sustained virological response (SVR) rate 59.6% regardless genotype;...
Background/Aims Recurrence after hepatic resection is one of the most important factors impacting prognosis and survival patients with hepatocellular carcinoma (HCC). We identified prognostic affecting overall (OS) disease-free (DFS) in HCC resection. Methods This study was a retrospective cohort design, 126 who underwent for at Gachon University Gil Medical Center between January 2005 December 2010 were enrolled. Various clinical, laboratory, pathological data evaluated to determine OS DFS....
Most patients with acute viral hepatitis A have a favorable course, but few of them suffer from severe forms such as fulminant hepatitis. This study was carried out to identify the factors influencing severity A.We retrospectively reviewed medical records 713 A, who were divided into two groups: (N=87) and non-severe (N=626). Severe defined or prolongation prothrombin time (INR≥1.5). Clinical variables compared between groups.The incidence 1.4 % (10/713) in A. Thirty-three (4.6 %) cases...
Background: Genetic variations in interleukin 28B (IL28B) have been strongly associated with a sustained virological response (SVR) European and African-American patients. variation of IL28B was investigated healthy controls chronic hepatitis C (CHC) patients, the treatment CHC patients analyzed according to polymorphism Korean population. Methods: polymorphisms (rs12979860 rs8099917) were studied 200 167 who treated peginterferon-α ribavirin. Results: The prevalence rs12979860 is as...
An 80-year-old woman with hilar cholangiocarcinoma was hospitalized due to sudden-onset abdominal pain. Computed tomography revealed hepatic necrosis accompanied emphysematous change in the superior segment of right liver (S7/S8), implying spontaneous rupture, based on presence perihepatic free air. Although urgent percutaneous drainage performed, neither pus nor fluids were drained. These findings suggest hepatitis a mass. Despite application intensive care, patient's condition deteriorated...