A5038228070- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- RNA modifications and cancer
- RNA Research and Splicing
- Horticultural and Viticultural Research
- Anorectal Disease Treatments and Outcomes
- Food Quality and Safety Studies
- Diverse Topics in Contemporary Research
- Plant Physiology and Cultivation Studies
- Diverse Approaches in Healthcare and Education Studies
- RNA and protein synthesis mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and Environmental Crop Studies
- Gene expression and cancer classification
- Consumer Perception and Purchasing Behavior
- Hormonal and reproductive studies
- Hedgehog Signaling Pathway Studies
- Postharvest Quality and Shelf Life Management
- Asian Culture and Media Studies
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Chinese history and philosophy
- Machine Learning in Bioinformatics
- Botanical Research and Chemistry
Korea Advanced Institute of Science and Technology
2021-2024
Institute for Basic Science
2018-2024
Korea Institute of Brain Science
2024
Seoul National University
2002-2023
Kootenay Association for Science & Technology
2022
Sungkyunkwan University
2007-2021
Samsung (South Korea)
2010-2021
Gyeongsangnam-do Agricultural Research and Extension Services
2019-2021
Rural Development Administration
2019-2021
Princeton University
2017-2020
miRNAs are small, non-coding RNAs that play important roles in various biological processes. The aims of our study were to investigate whether cell-free can be measured urine samples and might an accurate biomarker bladder cancer. Datasets GSE20418 GSE19717 used for analysis, two miRNAs, miR-145 miR-200a, selected study. A total 207 patients with primary transitional cell carcinoma the urinary 144 healthy normal controls enrolled. Using quantitative PCR, levels miR-200a compared...
A tale of not-so-pure tails The poly(A) tail mRNA has been thought to be a pure stretch adenosine nucleotides with little informational content except for length. Lim et al. identified enzymes that can decorate non-A nucleotides. noncanonical polymerases, TENT4A and TENT4B, incorporate intermittent residues (G, U, or C) preference guanosine, which results in heterogenous tail. Deadenylases trim initiate degradation but stall at the residues. In effect, stabilizes mRNAs by slowing down...
Clevudine is a pyrimidine analog with potent and sustained antiviral activity against HBV. In the present study, we evaluated safety efficacy of clevudine 30 mg daily for 24 weeks assessed durability response after cessation dosing in hepatitis B e antigen (HBeAg)-negative chronic (e-CHB). We randomized total 86 patients (3:1) to receive (n = 63) or placebo 23) weeks. followed an additional withdrawal treatment. The median changes HBV DNA from baseline were -4.25 -0.48 log(10) copies/mL at...
Abstract To develop an artificial intelligence (AI) model that predicts anti-vascular endothelial growth factor (VEGF) agent-specific anatomical treatment outcomes in neovascular age-related macular degeneration (AMD), thereby assisting clinicians selecting the most suitable anti-VEGF agent for each patient. This retrospective study included patients diagnosed with AMD who received three loading injections of either ranibizumab or aflibercept. Training was performed using optical coherence...
Abstract We used proteomics to detect regional differences in protein expression levels from mitochondrial fractions of control, ischemia–reperfusion (IR), and ischemic preconditioned (IPC) rabbit hearts. Using 2‐DE, we identified 25 proteins that were differentially expressed the IR heart compared with control IPC For three spots, patterns confirmed by Western blotting analysis. These included 3‐hydroxybutyrate dehydrogenase, prohibitin, 2‐oxoglutarate adenosine triphosphate synthases,...
Abstract Severe fever with thrombocytopenia syndrome virus was first discovered in 2009 as the causative agent of severe syndrome. Despite its potential threat to public health, no prophylactic vaccine is yet available. This study developed a heterologous prime-boost strategy comprising priming recombinant replication-deficient human adenovirus type 5 (rAd5) expressing surface glycoprotein, Gn, and boosting Gn protein. vaccination regimen induced balanced Th1/Th2 immune responses resulted...
Abstract Background Caffeine is the most commonly consumed psycho-stimulant in world. The effects of caffeine on body have been extensively studied; however, its effect structure brain has not investigated to date. Results In present study we found that long-term consumption can induce ventriculomegaly; this was observed 40% rats. caffeine-treated rats with ventriculomegaly, there increased production CSF, associated expression Na + , K -ATPase and cerebral blood flow (CBF). contrast chronic...
We compared the efficacy of desmopressin and enuresis alarm as first second line treatment options for monosymptomatic nocturnal enuresis.A total 104 children with were randomly assigned to either (54) or (50) treatment. Following 12 weeks a full response evaluated relapse after withdrawal Children partial no switched alternative then crossover Relapse was defined more than 1 episode bedwetting monthly.Following 77.8% group 82% achieved successful result, including in 37% 50% groups,...
The bladder cancer (BCa) microenvironment comprises heterogeneous tumor cell populations, the surrounding stroma and extracellular matrix (ECM). Collagen, scaffold of microenvironment, regulates ECM remodeling to promote infiltration, angiogenesis, invasion migration. present study examined how collagen type VI‑α (COL6A) 1 2 function during BCa pathogenesis progression, with aim facilitating development precision therapeutics, risk stratification molecular diagnosis. COL6A1 COL6A2 mRNA...
The influence of the preharvest application chitosan on physicochemical properties and changes in gene expression ‘Garmrok’ kiwifruit during postharvest cold storage (0 °C; RH 90–95%; 90 days) was investigated. Preharvest treatment increased fruit weight but had no significant effect size. suppressed ethylene production respiration rate storage. reduction chitosan-treated accompanied with biosynthesis genes. Moreover, diminished loss delayed that include firmness, soluble solids content,...
Abstract Shortening of messenger RNA poly(A) tails, or deadenylation, is a rate-limiting step in mRNA decay and highly regulated during gene expression. The incorporation non-adenosines ‘mixed tailing’, has been observed vertebrates viruses. Here, to quantitate the effect mixed we mathematically modeled deadenylation reactions at single-nucleotide resolution using an vitro system reconstituted with complete human CCR4–NOT complex. Applying this model, assessed disrupting impact single...