A5100713156- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Heat Transfer and Optimization
- Food Quality and Safety Studies
- Plant-Microbe Interactions and Immunity
- Advanced Semiconductor Detectors and Materials
- Hepatitis Viruses Studies and Epidemiology
- Toxin Mechanisms and Immunotoxins
- Pharmacological Effects of Natural Compounds
- Liver Disease and Transplantation
- Plant Pathogens and Fungal Diseases
- interferon and immune responses
- Influenza Virus Research Studies
- Radiative Heat Transfer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Heat Transfer and Boiling Studies
- Antimicrobial Peptides and Activities
- Herpesvirus Infections and Treatments
- Pituitary Gland Disorders and Treatments
- Agriculture, Soil, Plant Science
- Meningioma and schwannoma management
- Refrigeration and Air Conditioning Technologies
- Nutrition, Health and Food Behavior
Korea Institute of Oriental Medicine
2016-2025
Suwon Research Institute
2022
Tongmyong University
2022
Andong National University
2015-2021
Hanyang University Medical Center
2019-2021
Bradley University
2020
Mokwon University
2019
Kyung Hee University
2019
Korea Fisheries Resources Agency
2018
Korea Atomic Energy Research Institute
2012-2017
Abstract Bacillus genus produces several secondary metabolites with biocontrol ability against various phytopathogens. velezensis AK-0 (AK-0), an antagonistic strain isolated from Korean ginseng rhizospheric soil, was found to exhibit activity To further display the genetic mechanism of traits AK-0, we report complete genome sequence and compared it sequences closely related strains. We apple bitter rot caused by Colletotrichum gloeosporioides , which could lead commercialization this as a...
Clevudine is a pyrimidine analogue with potent and sustained antiviral activity against HBV. The present study evaluated the safety efficacy of 30 mg clevudine once daily for 24 weeks assessed durable response after cessation dosing. A total 243 hepatitis B e antigen (HBeAg)-positive chronic patients were randomized (3:1) to receive (n = 182) or placebo 61) weeks. Patients followed further off therapy. Median serum HBV DNA reductions from baseline at week 5.10 0.27 log10 copies/mL in groups,...
Clevudine is a pyrimidine analog with potent and sustained antiviral activity against HBV. In the present study, we evaluated safety efficacy of clevudine 30 mg daily for 24 weeks assessed durability response after cessation dosing in hepatitis B e antigen (HBeAg)-negative chronic (e-CHB). We randomized total 86 patients (3:1) to receive (n = 63) or placebo 23) weeks. followed an additional withdrawal treatment. The median changes HBV DNA from baseline were -4.25 -0.48 log(10) copies/mL at...
Non-alcoholic steatohepatitis (NASH) is characterized by hepatocellular injury and initial fibrosis severity has been suggested as an important prognostic factor of NASH. Silymarin was reported to improve carbon tetrachloride-induced liver reduce the activation hepatic stellate cells (HSC). We investigated whether silymarin could suppress HSCs in NASH induced methionine- choline-deficient (MCD) diet fed insulin-resistant rats. feeding MCD obese diabetic Otsuka Long-Evans Tokushima Fatty...
Herpes simplex virus type 1 (HSV-1), known to latently infect the host's trigeminal ganglion, can lead severe herpes encephalitis or asymptomatic infection, potentially contributing neurodegenerative diseases like Alzheimer's. The generates reactive oxygen species (ROS) that significantly impact viral replication and induce chronic inflammation through NF-κB activation. Nuclear factor E2-related 2 (Nrf2), an oxidative stress regulator, prevent treat HSV-1 infection by activating passive...
Abstract Influenza viruses are a serious threat to human health, causing numerous deaths and pandemics worldwide. To date, neuraminidase (NA) inhibitors have primarily been used treat influenza. However, there is growing need for novel NA owing the emergence of resistant viruses. Geranii Herba ( Geranium thunbergii Siebold et Zuccarini), which edible, has long in variety disease treatments Asia. Although recent studies reported its various pharmacological activities, effect components on...
Aloe vera ethanol extract (AVE) reportedly has significant anti-influenza virus activity, but its underlying mechanisms of action and constituents have not yet been completely elucidated. Previously, we confirmed that AVE treatment significantly reduces the viral replication green fluorescent protein-labeled influenza A in Madin-Darby canine kidney (MDCK) cells. In addition, post-treatment with inhibited matrix protein 1 (M1), 2 (M2), hemagglutinin (HA) mRNA synthesis (M1, M2, HA)...
This study aimed to investigate the effect of cold plasma treatment on improvement seed germination and surface sterilization ginseng seeds. Dehisced (Panax ginseng) seeds were exposed dielectric barrier discharge (DBD) operated in argon (Ar) or an argon/oxygen mixture (Ar/O2), resulting compared with those untreated control group. Bacterial fungal detection assays performed for plasma-treated after serial dilution surface-washed suspensions. The microbial colonies (fungi bacteria)...
The emergence of immune checkpoint inhibitors, a novel class immunotherapy drugs, represents major breakthrough in cancer immunotherapy, substantially improving patient survival post-treatment. Blocking programmed death-ligand 1 (PD-L1) and death protein-1 (PD-1) has demonstrated promising clinical results various human types. US FDA recently permitted only monoclonal antibody (mAb)-based PD-L1 or PD-1 blockers. Although these antibodies exhibit high antitumor efficacy, their size-...
To correlate the in vivo hydrogen 1 ((1)H) magnetic resonance (MR) spectroscopic features of chronic hepatitis-involved liver with histopathologic stages fibrosis.Seventy-five patients hepatitis were examined (1)H MR spectroscopy, which was performed right hepatic lobe. The peak areas glutamine and glutamate complex (Glx), phosphomonoesters (PME), glycogen glucose (Glyu), lipid measured on spectra. correlated findings at each stage hepatitis. Fifteen healthy volunteers also included as a...
Testicular microlithiasis (TM) is an uncommon pathologic condition that commonly diagnosed by scrotal ultrasonography. Indirect evidence suggests this syndrome may be associated with increased risk of testicular malignancy and infertility.A total 1,439 patients undergoing ultrasound during a 6-year, 5-month period (January 2003 to May 2009) were retrospectively reviewed. Any possible association TM findings was assessed. Among TM, further grading cancer semen analysis the infertile group...
The present study investigated the suppression of disease development anthracnose caused by Colletotrichum gloeosporioides and C. acutatum in harvested apples using an antagonistic rhizobacterium Paenibacillus polymyxa APEC128 (APEC128). Out 30 bacterial isolates from apple rhizosphere screened for activity, most effective strain was as inferred size inhibition zone. This showed a greater growth brain-heart infusion (BHI) broth compared to other media. There reduction symptoms two fungal...
Immune checkpoint inhibitors, increasingly used to treat malignant tumors, are revolutionizing cancer treatment by improving the patient survival expectations. Despite high antitumor efficacy of antibody therapeutics that bind PD-1/PD-L1, study on small molecule-based PD-1/PD-L1 inhibitors is required overcome side effects caused their size and affinity. Herein, we investigated potential Salvia plebeia R. Br. extract (SPE), which has been as a traditional oriental medicine food in many...
Microvascular invasion (MVI) is a well-known prognostic factor of postoperative recurrence and overall survival (OS) in patients with hepatocellular carcinoma (HCC). We compared the treatment outcomes transarterial chemoembolization (TACE) surgery/radiofrequency ablation (RFA) according to presence MVI early or late recurrent HCC that presented as Barcelona Clinical Liver Cancer (BCLC) stage 0 A after curative resection for HCC.A consecutive 68 BCLC at our institution between 1998 2012 were...
This study aims to describe the characterization of Paenibacillus polymyxa GBR-1 (GBR-1) with respect its positive and negative effects on plants. The morphological characteristics were identified microscopy, subjected Biolog analysis for identification. Bacterial population media optimization determined by a growth curve. potential as promoting agent, have antagonistic activity, hydrolytic activity at different temperatures was assessed. coinoculation other microorganisms pathogenicity...
Kaempferol (KO) and kaempferol 7-O-rhamnoside (KR) are natural products from various oriental herbs such as Geranii Herba. Previous studies have reported some biological activities of KO KR; however, their effects on PD-1/PD-L1 interaction not been yet. To elucidate inhibitory protein–protein (PPI), biochemical assays including competitive ELISA biolayer interferometry (BLI) systems were performed. Cellular blocking activity was measured in a co-culture system with PD-1 Jurkat PD-L1/aAPC...
The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome 2 (SARS-CoV-2). Despite the development of vaccines, emergence SARS-CoV-2 variants and absence effective therapeutics demand continual investigation COVID-19. Natural products containing active ingredients may be good therapeutic candidates. Here, we investigated effectiveness geraniin, main ingredient in medical plants Elaeocarpus sylvestris var. ellipticus Nephelium lappaceum, for treating spike...
To combat influenza A virus (IAV) infection, it is vital to develop effective therapeutic strategies, including immunomodulators. In this study, we examined the antiviral effects of Hovenia dulcis Thunb. honey (HDH) against IAV using RAW 264.7 cells. HDH treatment significantly reduced infection and viral protein expression. Moreover, enhanced production interferon (IFN)-β, activated innate immune response through cyclic GMP-AMP synthase (cGAS)-stimulator genes (STING) pathway, upregulated...
Epidemiologic studies were conducted on 31 cases of Salmonella group E infection detected in 2000 through a laboratory-based pathogen surveillance Gangwon Province, Korea. Data collected the environmental exposures and patients' foods, including brand(s) milk consumed before onset diarrhea. The medical records also reviewed. All patients infants under 10 months age except one 7-year old child. Surprisingly, all fed with infant formulas from Company A, although two both A B. Antimicrobial...