A5033978345- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Gastric Cancer Management and Outcomes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal and GI Pathology
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Screening and Detection
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal disorders and treatments
- Microbial Inactivation Methods
- Gastroesophageal reflux and treatments
- Nutrition and Health in Aging
- Helicobacter pylori-related gastroenterology studies
- Chronic Kidney Disease and Diabetes
- Heat shock proteins research
- Metastasis and carcinoma case studies
- Dysphagia Assessment and Management
- Viral gastroenteritis research and epidemiology
- Gastrointestinal Tumor Research and Treatment
- Endoplasmic Reticulum Stress and Disease
- Alcohol Consumption and Health Effects
- Magnetic and Electromagnetic Effects
- Abdominal vascular conditions and treatments
Korea University
2015-2024
Korea University Medical Center
2012-2020
Mayo Clinic
2013
WinnMed
2013
Mayo Clinic in Florida
2011
Ulsan University Hospital
2007
Seoul National University
2002
University of Ulsan
2002
Asan Medical Center
2002
Vasoactive drugs are recommended to be started as soon possible in suspected variceal bleeding, even before diagnostic endoscopy. However, it is still unclear whether the therapeutic efficacies of various vasoactive used comparable. The aim this prospective, multicenter, randomized, noninferiority trial was characterize effects terlipressin, somatostatin, and octreotide when they initiated endoscopic treatment patients with acute bleeding. Patients liver cirrhosis significant upper...
The most widely used method for diagnosing sarcopenia is the skeletal muscle index (SMI). Several studies have suggested that psoas thickness per height (PMTH) also effective detecting and predicting prognosis in patients with cirrhosis. aim of this study was to evaluate optimal cutoff values PMTH cirrhotic patients.All who underwent abdominal computed tomography (CT) scan including L3 umbilical levels measuring SMI transverse thickness, respectively, were included. Two definitions used: (1)...
Using the 10-item Spielberger Trait Anger Scale, authors interviewed 145 patients with stroke regarding inability to control anger or aggression (ICAA). Poststroke depression and emotional incontinence were also assessed. ICAA was present in 47 (32%) closely related motor dysfunction, dysarthria, incontinence, lesions affecting frontal-lenticulocapsular-pontine base areas. seems be one of major behavioral symptoms stroke.
To suggest a new cleansing score system for small bowel preparation and to evaluate its clinical efficacy.Twenty capsule endoscopy cases were reviewed was assessed with the scoring system. For assessment, two visual parameters used: proportion of visualized mucosa degree obscuration. Representative frames from images serially selected scored at 5-min intervals. Intraclass correlation coefficient (ICC) obtained assess reliability efficacy evaluation validation, scores our compared another...
Hepatic stellate cells (HSC) and liver endothelial (LEC) migrate to sites of injury perpetuate alcohol-induced injury. High-mobility group box 1 (HMGB1) is a protein released from the nucleus injured that has been implicated as proinflammatory mediator. We hypothesized HMGB1 may be ethanol-stimulated parenchymal contribute HSC LEC recruitment. Ethanol stimulation rat hepatocytes HepG2 resulted in translocation assessed by Western blot. levels were increased supernatant ethanol-treated...
Propranolol has been used as prophylaxis for variceal bleeding in patients with cirrhosis. More recent data suggest that carvedilol may be more effective reducing the hepatic venous pressure gradient (HVPG) than propranolol. The primary aim of this study was to evaluate hemodynamic response compared propranolol.A total 110 a baseline HVPG value >12 mm Hg were allocated randomly receive either or measurement repeated after 6 weeks daily medication. end point ≥20% fall <12 Hg.The difference...
Although the Psychometric Hepatic Encephalopathy Score (PHES) for diagnosis of minimal hepatic encephalopathy (MHE) has been validated in several countries, further validation is required its use different populations. The aims this study were thus to standardize PHES a healthy Korean population and evaluate prevalence MHE among patients with liver cirrhosis.Two-hundred subjects without evidence disease 160 cirrhosis overt HE included. Blood sampling routine laboratory tests determination...
AIM:To investigate whether suspected blood indicator (SBI) in capsule endoscopy (CE) is affected by background color and passage velocity. METHODS:Experimental models of the small intestine constructed from paper a variety colors were used to simulate observed CE images.The studied included very pale yellow, magenta, light grayish pink, burnt sienna, deep dark brown, red spots attached inside them.An endoscopic was manually passed through models.The rate detection SBI evaluated based on...
AIM:To evaluate the value of systemic inflammationbased markers as prognostic factors for advanced pancreatic cancer (PC). METHODS:Data from 82 patients who underwent combination chemotherapy with gemcitabine and erlotinib PC 2011 to 2014 were collected retrospectively.Data that included neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, C-reactive protein (CRP)-to-albumin (CRP/Alb) analyzed.Kaplan-Meier curves, univariate multivariate Cox proportional hazards regression...
The Baveno VI guidelines proposed criteria including liver stiffness (LS) and platelet count to avoid screening endoscopy in patients with compensated advanced chronic disease (cACLD). This study was performed validate the IV compare its diagnostic accuracy other non-invasive models.Patients cACLD who underwent laboratory tests, upper gastrointestinal abdominal ultrasound within 6 months of transient elastography were included.A total 1218 included. VNT occurred 249 (20.4%). With criteria,...
Despite antiviral therapy, liver function often fails to recover in patients with hepatitis B virus (HBV)-related decompensated cirrhosis.To establish a prognostic model predict re-compensation starting potent nucleos(t)ide analogue (NUC) therapy METHODS: We analysed 311 consecutive HBV-related cirrhosis treated entecavir or tenofovir. The primary outcome was re-compensation, defined as recovery Child-Pugh score of 5. BC2AID developed from cohort 152 subjects based on competing risk models...
Sarcopenia negatively affects the prognosis of cirrhotic patients, but clinical implications changes in muscle mass remain unclear. We aimed to elucidate its role outpatients with cirrhosis.Patients cirrhosis who underwent annual abdominal computed tomography (CT) for hepatocellular carcinoma surveillance were included prospective cohort. The L3 skeletal index (SMI) was adopted as a proxy amount muscle, and rate SMI change between inclusion after 1 year (ΔSMI/yr%) calculated.In total, 595...
Abstract Background/Aims: Serum creatinine (Cr) is not a reliable marker for early detection of renal dysfunction in patients with cirrhotic ascites. Several reports have suggested that cystatin C (CysC) more sensitive than Cr detecting reduced function these patients. This study evaluated the clinical significance CysC ascites and normal serum level. Methods: We enrolled level (<1.2 mg/dl). Liver tests, international normalized ratio (INR) levels were measured on same day all using...
The long-term clinical course, including the development of hepatocellular carcinoma (HCC) after hepatic B surface antigen (HBsAg) seroclearance is not established. We discovered that incidence HCC and risk factors for in chronic hepatitis (CHB) patients HBsAg seroclearance.During 28 years, 96 CHB with were retrospectively reviewed. These continued to undergo surveillance. median follow-up time from initial visit was 166.5 months (range, 7 321 mo).The mean age at 39.2 ± 10.6 years 46.4 9.9...
Background/Aims Hepatitis C virus (HCV) RNA testing can be performed using qualitative or quantitative assays, and it is still unclear which more useful as a primary test in patients positive for anti-HCV. The present study evaluated the usefulness of anti-HCV signal-to-cutoff ratio (S/CO ratio) predicting HCV results. Methods Patients on whom was due to enzyme immunoassay were enrolled. divided into viremia no-viremia groups according Receiver-operating characteristic (ROC) curve analysis...
Background/Aims Several studies suggested that serum cystatin C (CysC) is more useful than creatinine (Cr) for the assessment of renal function in patients with liver cirrhosis. This study evaluated clinical significance CysC cirrhotic ascites and normal Cr level. Methods We enrolled a level (<1.2 mg/dL). GFR was measured by 99mTc-DTPA scan. Serum Cr, CysC, clearance (CCr) were on same day. Significant impairment severe defined as <60 mL/min <30 mL/min, respectively. Results Eighty-nine (63...
Goals: The aim of this study was to evaluate the risk factors and clinical significance terlipressin-induced hyponatremia. Background: Patients receiving terlipressin treatment frequently develop However, its are not fully elucidated. Study: Records patients treated with for variceal bleeding were analyzed. Hyponatremia defined as a decrease in serum sodium (Na) level >5 mEq/L from baseline level; severe hyponatremia Na >10 rapid within 3 days treatment. Results: involved 151 (mean age,...
Abstract Background Suppression of hepatitis B virus ( HBV ) DNA is more potent, and occurrence resistant strain rare with entecavir than lamivudine, but whether these merits result in a favourable outcome ‐related decompensated cirrhosis patients unclear. Aims To compare virologic response, changes liver function, clinical course predictive factors for early mortality after treatment between treated lamivudine those patients. Methods [Child‐Turcotte‐Pugh CTP score ≥ 7] either or were...
We investigated long-term outcomes and prognostic factors in patients with hepatitis B virus (HBV)-related liver cirrhosis the era of oral nucleos(t)ide analog antiviral agents.Between January 1999 February 2009, a total 240 consecutive who had HBV-related without malignancy were treated lamivudine second line analogs. The group historical controls consisted 481 managed any treatment prior to 1999.In 78% received treatment, sustained viral suppression (serum HBV DNA < 10(5) copies/mL) was...
Background/Aims In patients with liver cirrhosis, drugs acting on the central nervous system can lead to hepatic encephalopathy and effects may be prolonged. Recently, misuse of propofol has been reported associated risk death have become an issue. Propofol is commonly used during sedative endoscopy; therefore, its safety in high-risk groups must further investigated. We performed a pilot study efficacy endoscopy Korean cirrhosis. Methods Upper gastrointestinal was under sedation along...
Objectives. The superiority of conventional polyethylene glycol (PEG) solution over sodium picosulfate with magnesium citrate (SPMC) for bowel preparation remains controversial. Therefore, this study compared the efficacy, safety, and tolerability different regimens SPMC PEG in Koreans, who consume a traditional high-fiber diet. Materials methods. A total 200 outpatients undergoing elective colonoscopy were randomized into four groups receiving bowel-preparation prospective study: 4 L...