A5100424893- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Silk-based biomaterials and applications
- Liver Disease and Transplantation
- Vector-borne infectious diseases
- Cancer Mechanisms and Therapy
- Phytochemical compounds biological activities
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Protein Hydrolysis and Bioactive Peptides
- Hepatitis Viruses Studies and Epidemiology
- Pancreatitis Pathology and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Amoebic Infections and Treatments
- Head and Neck Anomalies
- Recommender Systems and Techniques
- Pituitary Gland Disorders and Treatments
- Microencapsulation and Drying Processes
- Lipid metabolism and disorders
- Garlic and Onion Studies
Korea University
2010-2017
Korea University Medical Center
2009-2014
Previous studies have shown that angiopoietin-like protein 8 (ANGPTL8), also called as betatrophin, acts together with ANGPTL3 to regulate lipid metabolism, glucose and energy homeostasis. Moreover, ANGPTL8 promotes proliferation of pancreatic β-cells induces insulin secretion. However, there are no previous longitudinal in humans.We analyzed the age- sex-matched data 240 normal weight overweight Korean children from Metabolic disorders Obesity Study Elementary School (K-MOSES), a...
α-Fetoprotein (AFP) is the biomarker most widely used to detect hepatocellular carcinoma (HCC), despite its suboptimal diagnostic accuracy. Glypican-3 (GPC3) and osteopontin (OPN) are secreted glycoproteins that reportedly associated with tumorigenesis metastasis. This study was conducted evaluate clinical utility of using plasma GPC3 OPN as biomarkers for HCC.We measured levels in 120 HCC 40 chronic liver disease (CLD) patients via an enzyme-linked immunosorbent assay. The accuracy each...
Active compounds with antidiabetic potential were isolated from silk peptide E5K6 by consecutive ultrafiltration and gel filtration using Biogel P-2 RS-HPLC a YMC-Pack Pro C18 column. The highest α-glucosidase inhibitory activity of resulted fractions MW <1 kDa. activities gel-filtered kDa assayed in vitro, demonstrating that the fourth peak (F4) had (IC50 = 37.1 mg/mL). F4 was separated HPLC into two peaks. Moreover, purified identified as Gly-Glu-Tyr (GEY, 367 Da) Gly-Tyr-Gly (GYG, 295...
The prognostic role of aberrant serum miRNA expression for predicting response to sorafenib treatment in advanced hepatocellular carcinoma (HCC) patients has not been well characterized.We aimed identify specific miRNAs that are associated with positive radiologic responses or improved survival sorafenib-treated HCC patients.miR-18a, miR-21, miR-139-5p, miR-221, miR-224, and miR-10b-3p, were selected analysis.Serum samples from 24 stage 25 liver cirrhosis (LC) analyzed.All the except miR-21...
We investigated changes in hepatitis B surface antigen (HBsAg) level and its correlation with clinical outcomes treatment-naive chronic (CHB) patients undergoing entecavir therapy.Among 51 e (HBeAg)-positive CHB receiving for more than 1 year, 28 were enrolled. HBsAg levels measured at baseline, 6 months, 12 months after treatment using the Architect QT assay (Abbott, dynamic; range: 0.05 to 125,000 IU/mL). Serum alanine aminotransferase, HBeAg, anti-HBe, virus (HBV) DNA (Cobas Taqman: low...
The long-term clinical course, including the development of hepatocellular carcinoma (HCC) after hepatic B surface antigen (HBsAg) seroclearance is not established. We discovered that incidence HCC and risk factors for in chronic hepatitis (CHB) patients HBsAg seroclearance.During 28 years, 96 CHB with were retrospectively reviewed. These continued to undergo surveillance. median follow-up time from initial visit was 166.5 months (range, 7 321 mo).The mean age at 39.2 ± 10.6 years 46.4 9.9...
Previous studies have shown that chronic kidney disease (CKD) is associated with accelerated loss of skeletal muscle in patients on dialysis. However, the relationships sarcopenia albuminuria and early-stage CKD type 2 diabetes not been examined. We analyzed diabetic subgroup data from 409 Korean Sarcopenic Obesity Study (KSOS). Sarcopenia was defined as a mass index (SMI; SMI [%] = total [kg]/weight [kg] × 100) less than SD below sex-specific mean for younger reference group. The estimated...
Acute hepatitis A is currently outbreaking in Korea. Although prognosis of acute generally favorable, a minority patients are accompanied by fatal complications. Severe cholestasis one the important causes prolonged hospitalization with A. In such cases, higher chances additional complications and increased medical costs inevitable. We report three cases severely cholestatic A, who showed favorable responses to oral corticosteroids. Thirty milligram prednisolone was initiated tapered...
Necrotizing pancreatitis is one of the rare complications transcatheter arterial chemoembolization (TACE). after TACE may result from development ischemia caused by regurgitation embolic materials into vessels supplying pancreas. We report a case post-TACE necrotizing with abscess formation in patient hepatocellular carcinoma. The had suffered hepatic artery injury due to repetitive TACE; during his 25th procedure he submitted selective catheterization feeding vessel dorsal pancreatic...
Background/Aim Clevudine and entecavir are highly potent antiviral agents being used in treatment of chronic hepatitis B. However, no data comparing clinical efficacy safety these 2 drugs over a long-term period is available. The aims this study to compare virologic, biochemical, serologic response rates clevudine entecavir, as well failure up years. Methods Data patients who started (n=86) or (n=159) primary for B at Korea University Ansan Guro Hospital between January 2007 June 2008 were...
The goal of the study was to compare efficacy and safety sorafenib with those systemic cytotoxic chemotherapy.Sorafenib treatment has shown improve survival in patients advanced hepatocellular carcinoma (HCC) when compared placebo. However, whether controls advanced-stage HCC better than chemotherapy not been elucidated.We retrospectively reviewed medical records 220 measurable who had received previously between January 2007 April 2012. Among these patients, 78 treated sorafenib. Another 14...
An association between past history of hepatitis B virus (HBV) infection and pancreatic cancer (PC) has recently been reported. We investigated whether HBV C (HCV) infections are associated with the development PC in Korea.We retrospectively recruited patients sex- and, age-matched control stomach (SC) during previous 5 years. Serum HBsAg anti-HCV were examined, data on smoking, alcohol intake, diabetes, chronic pancreatitis (CP) collected.A total 506 1008 SC enrolled, respectively 58.1%...
Terlipressin is a vasopressin analogue that widely used in the treatment of hepatorenal syndrome or variceal bleeding. Because it acts mainly on splanchnic vessels, terlipressin has lower incidence severe ischemic complications than does vasopressin. However, can still lead to serious such as myocardial infarction, skin necrosis, bowel ischemia. Herein we report case necrosis 46-year-old cirrhotic patient treated with terlipressin. Although received resection, death occurred due ongoing...
While imported falciparum malaria has been increasingly reported in recent years Korea, clinicians have difficulties making a clinical diagnosis as well having accessibility to effective anti-malarial agents. Here we describe an unusual case of with severe hemolytic anemia lasting over 2 weeks, clinically mimicking coinfection babesiosis. A 48-year old Korean man was diagnosed France after traveling the Republic Benin, West Africa. He received 1-day course intravenous artesunate and 7-day...
Abstract Background and Aims: Transient elastography (TE) is useful for predicting the fibrosis stage, but it unsatisfactory as a substitute liver biopsy, especially in patients with chronic hepatitis B (CHB). This study was performed to establish reliable model significant (SF) CHB. Methods: All CHB who were admitted undergo biopsy enrolled. They randomly classified into either training set ( n = 139) or validation 69). A SF established validated set. Low high cutoff values (COVs) chosen...
Abstract BACKGROUND In this study, the tri‐peptides Gly‐Glu‐Tyr ( GEY ) and Gly‐Tyr‐Gly GYG ), identified previously as active compounds from silk peptide E5K6 , significantly stimulated basal insulin‐mediated glucose uptake by 3T3‐L1 fibroblasts in a dose‐dependent manner. RESULTS Synthetic peptides at concentration of 500 µmol L −1 increased transporter type 4 expression 157% 239%, respectively. Differentiation cells into adipocytes leads to accumulation intracellular fat droplets, 250...
Data regarding the management of adefovir (ADV) resistance are still limited. The aim this study is to investigate treatment outcomes rescue therapy in ADV-resistant chronic hepatitis B (CHB) patients.CHB patients who began due documented genotypic mutations ADV between October 2006 and July 2012 were retrospectively reviewed.Sixty-three included study. Most had history lamivudine (LAM) resistance. Treatment response was evaluated at 3-month intervals up 12 months. cumulative rate complete...