A5079152828- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protein Tyrosine Phosphatases
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Eosinophilic Esophagitis
- Antiplatelet Therapy and Cardiovascular Diseases
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Coronary Interventions and Diagnostics
- Gut microbiota and health
- Platelet Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
Korea University Medical Center
2016-2025
Michigan State University
2025
Korea University
2012-2024
Yang Hospital
2015-2023
University of California, San Diego
2018-2022
Catholic University of Korea
2012
RELX Group (United States)
2012
Post Graduate Institute of Medical Education and Research
2009
Ewha Womans University
2007
Ewha Womans University Medical Center
2007
Irritable bowel syndrome (IBS) is a complex disorder characterized by abdominal symptoms including chronic pain or discomfort and altered habits. The etiology of IBS multifactorial, as abnormal gut motility, visceral hypersensitivity, disturbed neural function the brain-gut axis an autonomic nervous system are all implicated in disease progression. Based on recent experimental clinical studies, it has been suggested that additional etiological factors low-grade inflammation, microbiota...
Astaxanthin is a carotenoid pigment that has antioxidant, antitumoral, and anti-inflammatory properties. In this in vitro study, we investigated the mechanism of anticancer effects astaxanthin gastric carcinoma cell lines.The human adenocarcinoma lines AGS, KATO-III, MKN-45, SNU-1 were treated with various concentrations astaxanthin. A viability test, cycle analysis, immunoblotting performed.The each cancer line was suppressed by dose-dependent manner significantly decreased proliferation...
To evaluate the efficacy of cola treatment for gastric phytobezoars, including diospyrobezoars.A total 17 patients (range: 48 to 78 years) with symptomatic phytobezoars treated and adjuvant endoscopic therapy were reviewed. Three liters lavage (10 cases) or drink (7 initially used, then fragmentation was done remnant bezoars by using a lithotripsy basket polypectomy snare. The overall success dissolving three clinical findings compared retrospectively between four cases complete dissolution...
This study was aimed to evaluate the prevalence of eosinophilic esophagitis (EoE) among patients with esophageal or upper gastrointestinal (UGI) symptoms.Patients UGI symptoms including dysphagia food impaction, acid regurgitation, heartburn, chest pain, epigastric nausea and/or vomiting were prospectively collected. The enrolled responded a symptomatic questionnaire and underwent an esophagogastroduodenoscopy biopsies. Supportive endoscopic findings EoE (ring-like appearance, liner furrows,...
Abstract Background: The risk of excessive bleeding prompts physicians to stop multiple antiplatelet agents before minor surgery, which puts coronary stenting patients at for adverse thrombotic events. Hypothesis: We hypothesized that most dental extractions can be carried out safely without stopping agents. Methods: All extraction who had undergone and were also on oral therapy enrolled. One hundred underwent procedures wounds sutured followed up 24 hours, 1 week, month after the procedure....
Background/Aims: The use of self-expandable metallic stents (SEMS) is an established palliative treatment for malignant stenosis in the gastrointestinal tract; therefore, its application to benign expected be beneficial because more gradual and sustained dilatation stenotic portion.We aimed this prospective observational study evaluate efficacy safety temporary SEMS placement pyloric stenosis.Methods: Twenty-two patients with prepylorus, pylorus, duodenal bulb were enrolled underwent...
Background/Aims: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal in stomach.We evaluated clinical outcomes of endoscopic treatment for gastric GISTs.Methods: This is a single center, retrospective study that enrolled 135 cases subepithelial (SETs) resected by procedures and confirmed as GISTs histopathology from March 2005 to July 2019.The immediate long-term were analyzed retrospectively. Results:The mean patient age was 57.9 years, tumor size 2.1 cm.Of tumors, 43.0%...
Objective Non-variceal upper gastrointestinal bleeding (NVUGIB) in patients receiving oral anticoagulants (OACs) may be fatal; however, little is known about re-bleeding and all-cause mortality after successful hemostasis. We investigated the clinical characteristics risk factors for death hemostasis.Methods Patients OACs diagnosed with NVUGIB between 2007 2021 were enrolled. All incidents confirmed if definite tract was detected via esophagogastroduodenoscopy.Results A total of 132 NVUGIB....
The long-term clinical course, including the development of hepatocellular carcinoma (HCC) after hepatic B surface antigen (HBsAg) seroclearance is not established. We discovered that incidence HCC and risk factors for in chronic hepatitis (CHB) patients HBsAg seroclearance.During 28 years, 96 CHB with were retrospectively reviewed. These continued to undergo surveillance. median follow-up time from initial visit was 166.5 months (range, 7 321 mo).The mean age at 39.2 ± 10.6 years 46.4 9.9...
We investigated the inhibitory effect of pantoprazole on signal transducer and activator transcription 3 (STAT3) activity invasiveness gastric adenocarcinoma cells, role SH2-containing protein tyrosine phosphatase 1 (SHP-1) in mediating role.We used AGS MKN-28 cells because reduced SHP-1 preserved p-STAT3 expression. Western blot, wound closure assay, Matrigel invasion assay 3-D culture were performed. Pharmacologic inhibitor siRNA for validation SHP-1.We observed that at 40, 80, 160 μg/ml...
Background/Aims In patients with liver cirrhosis, drugs acting on the central nervous system can lead to hepatic encephalopathy and effects may be prolonged. Recently, misuse of propofol has been reported associated risk death have become an issue. Propofol is commonly used during sedative endoscopy; therefore, its safety in high-risk groups must further investigated. We performed a pilot study efficacy endoscopy Korean cirrhosis. Methods Upper gastrointestinal was under sedation along...
We investigated the effect of arsenic trioxide (ATO) for inhibition signal transducer and activator transcription 3 (STAT3) epithelial-mesenchymal transition (EMT) in gastric cancer cells, role SH2 domain-containing phosphatase-1 (SHP-1) during this process. used AGS which showed minimal SHP-1 expression constitutive STAT3 expression. After treatment ATO, cellular migration invasion were assessed by using wound closure assay, Matrigel assay 3-D culture assay. To validate SHP-1, pervanadate,...
Abstract Background and Aim The aim of this study was to compare HOXB7 expression level between gastric cancer non‐cancerous tissues. Additionally, the functional effects HOXB7, including its pro‐migration or invasion anti‐apoptosis roles, were evaluated in cells. Methods Both gene protein levels examined cell lines, compared primary metastatic tissues chronic gastritis intestinal metaplasia Functional studies included a wound healing assay, Matrigel an Annexin‐V assay performed, Akt/PTEN...
Several specific foods are known to precipitate gastroesophageal reflux disease (GERD) symptoms and GERD patients usually advised avoid such foods. However, consumed daily quite variable according regions, cultures, etc. This study was done elucidate the food items which induce typical in Korean patients.One hundred twenty-six with weekly were asked mark all that induced from a list containing 152 Korea. All underwent upper gastrointestinal endoscopy followed by 24-hour ambulatory esophageal...
Background/Aims: To investigate the incidence of cholangiocarcinoma in patients with hepatolithiasis or without previous resection liver.Methods: From 2002 to 2009, we retrospectively reviewed 117 who were diagnosed and treated for Korea University Guro Hospital.Among patients, 55 lost during follow-up excluded, 62 eligible analysis.The hepatic group (n=25) included underwent left hemihepatectomy (n=2); lateral segmentectomy (n=10); lobectomy (n=9); right (n=3); wedge (n=1).The nonhepatic...
A recent study reported that plumbagin downregulated the activity of Janus kinase 2 (JAK2)‑signal transducer and activator transcription 3 (STAT3) pathway to show various antitumor effects in multiple myeloma cells. We aimed this vitro demonstrate inhibition JAK2/STAT3 by through inducing SH2‑containing protein tyrosine phosphatase 1 (SHP1) expression MKN‑28 gastric cancer cell line. performed western blot analysis measure SHP1, phospho‑JAK2/STAT3 level, observed induced SHP1 simultaneously...
Abstract Background and Aim PBK‐1701TC is a novel sulfate tablet‐based that contains 320 mg of simethicone delivers 90% the salt water delivered by oral solution (OSS) preparation. This study evaluated efficacy, safety, tolerability compared with OSS in bowel preparation for colonoscopy. Methods randomized, multicenter, phase 3 non‐inferiority trial included adults aged 19 years or older body mass index 19–30 kg/m 2 undergoing colonoscopy at five university hospitals Korea. The primary...