A5080184285- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Liver Disease and Transplantation
- Gastroesophageal reflux and treatments
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Eosinophilic Esophagitis
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Screening and Detection
- Dysphagia Assessment and Management
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Liver Diseases and Immunity
- Lymphoma Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Neuroendocrine Tumor Research Advances
Korea University
2008-2017
Samsung (South Korea)
2017
Korea University Medical Center
2002-2012
Seoul National University Bundang Hospital
2011
Post Graduate Institute of Medical Education and Research
2009
Ansan University
2005
Digestive Health Research Institute
2001
Kurume University
2001
Oklahoma Medical Research Foundation
1997
The cancer stem cell (CSC) hypothesis has important clinical implications for therapeutics because of the proposed role CSCs in chemoresistance. aim this study was to investigate changes CSC populations before and after primary systemic therapy (PST) their prognostic human breast cancer.Paired samples (before PST) tissue were obtained from stage II or III patients (n=92) undergoing PST with regimen doxorubicin plus docetaxel (AD) (n=50) cyclophosphamide (AC) (n=42) subsequent resection....
AIM:To compare the effectiveness of sequential therapy for Helicobacter pylori (H.pylori ) infection with that triple varying durations. METHODS:The 460 patients enrolled in this study had H. -associated gastritis or a gastric duodenal ulcer.After screening, -infected were randomly assigned to receive either conventional 7, 10 14 d, new 10-d therapy.Each 4 treatment groups included 115 patients.The outcomes eradication assessed wk after by urea breath test and histology. RESULTS:The overall...
To evaluate the efficacy of cola treatment for gastric phytobezoars, including diospyrobezoars.A total 17 patients (range: 48 to 78 years) with symptomatic phytobezoars treated and adjuvant endoscopic therapy were reviewed. Three liters lavage (10 cases) or drink (7 initially used, then fragmentation was done remnant bezoars by using a lithotripsy basket polypectomy snare. The overall success dissolving three clinical findings compared retrospectively between four cases complete dissolution...
It remains unclear whether the currently-used normal range for serum alanine aminotransferase (ALT) levels really reflects a healthy liver. The present study was conducted to evaluate of ALT in Korean adult population and determine clinical significance unhealthy levels.We reviewed medical records, including questionnaires results laboratory radiological tests at Health Promotion Center Korea University Anam Hospital between March 2005 February 2007. written questionnaire form, included...
To suggest a new cleansing score system for small bowel preparation and to evaluate its clinical efficacy.Twenty capsule endoscopy cases were reviewed was assessed with the scoring system. For assessment, two visual parameters used: proportion of visualized mucosa degree obscuration. Representative frames from images serially selected scored at 5-min intervals. Intraclass correlation coefficient (ICC) obtained assess reliability efficacy evaluation validation, scores our compared another...
Although reflux esophagitis is believed to be common in the Western population, very few epidemiologic data on Koreans are available. The aims of this study were evaluate prevalence endoscopic patients who came for a physical check-up at Korea University Hospital, and relationship between various factors relevant disease.This was carried out prospectively 7,015 received an esophagogastroduodenoscopy from September 1996 December 1997. Most free symptoms had come their self-paid check-up.The...
Submucosal injection is used to prevent complications, such as perforation, during endoscopic mucosal resection (EMR). Since of normal saline produces elevation short duration, repeated needed for extensive resection. To overcome this limitation, various submucosal solutions have been developed but there are few data comparing their efficacy. This study was therefore conducted compare the physical and chemical properties duration solutions.A fresh transverse colon specimen acquired from a...
Although the Psychometric Hepatic Encephalopathy Score (PHES) for diagnosis of minimal hepatic encephalopathy (MHE) has been validated in several countries, further validation is required its use different populations. The aims this study were thus to standardize PHES a healthy Korean population and evaluate prevalence MHE among patients with liver cirrhosis.Two-hundred subjects without evidence disease 160 cirrhosis overt HE included. Blood sampling routine laboratory tests determination...
AIM:To investigate whether suspected blood indicator (SBI) in capsule endoscopy (CE) is affected by background color and passage velocity. METHODS:Experimental models of the small intestine constructed from paper a variety colors were used to simulate observed CE images.The studied included very pale yellow, magenta, light grayish pink, burnt sienna, deep dark brown, red spots attached inside them.An endoscopic was manually passed through models.The rate detection SBI evaluated based on...
Abstract Background/Aims: Serum creatinine (Cr) is not a reliable marker for early detection of renal dysfunction in patients with cirrhotic ascites. Several reports have suggested that cystatin C (CysC) more sensitive than Cr detecting reduced function these patients. This study evaluated the clinical significance CysC ascites and normal serum level. Methods: We enrolled level (<1.2 mg/dl). Liver tests, international normalized ratio (INR) levels were measured on same day all using...
Background/Aims Hepatitis C virus (HCV) RNA testing can be performed using qualitative or quantitative assays, and it is still unclear which more useful as a primary test in patients positive for anti-HCV. The present study evaluated the usefulness of anti-HCV signal-to-cutoff ratio (S/CO ratio) predicting HCV results. Methods Patients on whom was due to enzyme immunoassay were enrolled. divided into viremia no-viremia groups according Receiver-operating characteristic (ROC) curve analysis...
Background/Aims Several studies suggested that serum cystatin C (CysC) is more useful than creatinine (Cr) for the assessment of renal function in patients with liver cirrhosis. This study evaluated clinical significance CysC cirrhotic ascites and normal Cr level. Methods We enrolled a level (<1.2 mg/dL). GFR was measured by 99mTc-DTPA scan. Serum Cr, CysC, clearance (CCr) were on same day. Significant impairment severe defined as <60 mL/min <30 mL/min, respectively. Results Eighty-nine (63...
Goals: The aim of this study was to evaluate the risk factors and clinical significance terlipressin-induced hyponatremia. Background: Patients receiving terlipressin treatment frequently develop However, its are not fully elucidated. Study: Records patients treated with for variceal bleeding were analyzed. Hyponatremia defined as a decrease in serum sodium (Na) level >5 mEq/L from baseline level; severe hyponatremia Na >10 rapid within 3 days treatment. Results: involved 151 (mean age,...
The survival of a recent series 823 cirrhosis patients who were followed up for mean 48 months was analyzed. Cirrhosis ascribed to alcohol (26%), hepatitis virus B (58%), C (11%) or both (2%), cryptogenic (3%). Features decompensation observed in 51% the at entry, and newly developed 44% compensated within 5 yr. 5-yr after 25%. leading causes death liver failure (53%), hepatocellular carcinoma (HCC, 23%), variceal bleeding (10%). Early detection HCC significantly improved patients. Biannual...
It is still uncertain whether the accuracy of transient elastography (TE) in predicting fibrosis stage similar chronic hepatitis B (CHB) and C (CHC). The present study was carried out to evaluate underlying cause viral affects predictive TE.Patients with CHB or CHC who were admitted for a liver biopsy enrolled. Patients underwent TE laboratory tests on same day as biopsy. analyzed by comparing areas under receiver-operating characteristic curves (AUCs).Two-hundred seven patients enrolled,...
Summary. The findings of several studies suggest that liver stiffness values can be affected by the degree intrahepatic congestion respiration influence blood volume and may affect stiffness. We evaluated on Transient elastography (TE) was performed at end inspiration expiration in patients with chronic disease. median obtained during set were defined as inspiratory expiratory stiffness, respectively. A total 123 disease enrolled (mean age 49 years; 64.2% men). Liver cirrhosis coexisted 29...
Background: Patients with cirrhosis have an increased risk of mortality after surgery. In 2007, a new model was suggested to calculate at specific time points surgery the Mayo clinic. Aims: We investigated risks in Korean cirrhotic patients who underwent various surgeries and applied clinic our study populations. Methods: conducted retrospective review charts 160 surgical procedures under general anaesthesia between January 1996 December 2006 two hospitals. Results: The overall 30-, 90-day...
Abstract Background Suppression of hepatitis B virus ( HBV ) DNA is more potent, and occurrence resistant strain rare with entecavir than lamivudine, but whether these merits result in a favourable outcome ‐related decompensated cirrhosis patients unclear. Aims To compare virologic response, changes liver function, clinical course predictive factors for early mortality after treatment between treated lamivudine those patients. Methods [Child‐Turcotte‐Pugh CTP score ≥ 7] either or were...
We investigated long-term outcomes and prognostic factors in patients with hepatitis B virus (HBV)-related liver cirrhosis the era of oral nucleos(t)ide analog antiviral agents.Between January 1999 February 2009, a total 240 consecutive who had HBV-related without malignancy were treated lamivudine second line analogs. The group historical controls consisted 481 managed any treatment prior to 1999.In 78% received treatment, sustained viral suppression (serum HBV DNA < 10(5) copies/mL) was...