A5032194107- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Extracellular vesicles in disease
- Liver physiology and pathology
- Natural Antidiabetic Agents Studies
- Phagocytosis and Immune Regulation
- Diet, Metabolism, and Disease
- COVID-19 and healthcare impacts
- Viral gastroenteritis research and epidemiology
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- MicroRNA in disease regulation
- Healthcare cost, quality, practices
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Diabetes and associated disorders
- Gastric Cancer Management and Outcomes
- Vaccine Coverage and Hesitancy
- Eicosanoids and Hypertension Pharmacology
- Endoplasmic Reticulum Stress and Disease
- Magnetic Bearings and Levitation Dynamics
- COVID-19 and Mental Health
- Advanced Battery Technologies Research
Netaji Subhas University of Technology
2024
Malaviya National Institute of Technology Jaipur
2024
Institute of Medical Sciences
2023
Punjab Engineering College
2021-2023
University of Delhi
2022
Mayo Clinic in Arizona
2015-2021
Galgotias University
2021
King George's Medical University
2021
Lala Lajpat Rai University of Veterinary and Animal Sciences
2020
Mayo Clinic
2013-2018
Background and Aims Interleukin‐22 has beneficial effects on inflammation impaired hepatic regeneration that characterize alcohol‐associated hepatitis (AH). F‐652 is a recombinant fusion protein of human interleukin‐22 immunoglobulin G2 fragment crystallizable. This study aims to assess the safety efficacy signals in patients with moderate severe AH. Approach Results A phase‐2 dose‐escalating was carried out. (10 μg/kg, 30 or 45 μg/kg) administered days 1 7 tested 3 each (Model for End‐Stage...
Liver fibrosis is characterized by the activation and migration of hepatic stellate cells (HSCs), followed matrix deposition. Recently, several studies have shown importance extracellular vesicles (EVs) derived from liver cells, such as hepatocytes endothelial in pathobiology. While most describe how modulate HSC behavior, an important gap exists understanding HSC‐derived signals more specifically EVs fibrosis. Here, we investigated molecules released through EVs, mechanism their release,...
Liver microenvironment is a critical determinant for development and progression of liver metastasis. Under transforming growth factor beta (TGF‐β) stimulation, hepatic stellate cells (HSCs), which are liver‐specific pericytes, transdifferentiate into tumor‐associated myofibroblasts that promote tumor implantation (TI) in the liver. However, regulation this HSC activation process remains poorly understood. In study, we tested whether vasodilator‐stimulated phosphoprotein (VASP) HSCs...
Background & AimsTransdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived (PDGF) are canonical HSC activators after injury. The aim this study was to analyze epigenetic modulators that differentially control TGF-β PDGF signaling pathways.MethodsWe performed transcriptomic comparison HSCs treated with or PDGF-BB using RNA sequencing. Among targets distinguish these 2...
Hepatic stellate cells (HSC) and liver endothelial (LEC) migrate to sites of injury perpetuate alcohol-induced injury. High-mobility group box 1 (HMGB1) is a protein released from the nucleus injured that has been implicated as proinflammatory mediator. We hypothesized HMGB1 may be ethanol-stimulated parenchymal contribute HSC LEC recruitment. Ethanol stimulation rat hepatocytes HepG2 resulted in translocation assessed by Western blot. levels were increased supernatant ethanol-treated...
The co-infection of Hepatitis B and C viruses with HIV accelerates disease progression also has an effect on the management patients infected HIV. prevalence hepatitis varies widely. This study is planned to evaluate in North India.A total 1178 enrolled ART center were retrospectively analyzed for presence HBV HCV basis HBsAg anti-HCV markers.In HIV, was 9.9% (117/1178), 6.3% (74/1178) both ~1% (12/1178).The rate are increasing Having acquired knowledge about importance such a co-infection,...
Due to the unprecedented and repeated outbreak of coronavirus pandemic its highly contagious nature, social life people every strata society across globe considerably affected both economically as well mentally. The most who earn their subsistence on a daily basis, working in unorganised sector, patients suffering from co-morbidity, need regular check-ups, government imposed lockdown restricted movement check spread COVID-19. Despite low fatality rate, created havoc among mainly due...
Interleukin-22 (IL-22) is a Th17 cell hepatoprotective cytokine that undergoing clinical trials to treat patients with alcoholic hepatitis (AH). Lipopolysaccharide (LPS) activation of macrophage implicated in hepatocyte death and pathogenesis AH. The role IL-22 production from macrophage, its regulation by LPS, effects on alcohol-induced are unexplored were examined this study. Low levels mRNA/protein detected but significantly upregulated 6.5-fold response the tissue reparative IL-10....
Objective: An open label, controlled clinical study was conducted in Indian infants aged 6-14 weeks to compare the immunogenicity and safety of a reconstituted pentavalent vaccine (DTwP-HBV+Hib) Serum Institute India Ltd (SIIL) with TritanrixHB+Hiberix Glaxo Smithkline (GSK). Methods: Eligible were randomized receive three doses / comparator vaccine. The vaccines prior administration, by mixing DTwP-HBV (liquid) Hib (lyophilized) IgG antibody titres assessed ELISA at baseline after one month...
The scaffold protein synectin plays a critical role in the trafficking and regulation of membrane receptor pathways. As platelet-derived growth factor (PDGFR) is essential for hepatic stellate cell (HSC) activation liver fibrosis, we sought to determine on PDGFR pathway development fibrosis. Mice with deletion from HSC were found be protected mRNA sequencing revealed that knockdown demonstrated reductions fibrosis genes, including PDGFR-β. Chromatin IP assay PDGFR-β promoter upon pattern...
Several studies have shown that expression of zinc-finger protein 143 (ZNF143) is closely related to tumour progression including colon cancer. However, it remains unclear how ZNF143 within the microenvironment. Here, we investigated whether affects microenvironment and by screening molecules secreted cancer cells stably expressing short-hairpin RNAs against or control RNAs. We observed secretion interleukin (IL)-8 was increased when reduced in two cell lines. The mRNA levels IL-8 were...