A5050657039- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Urinary Tract Infections Management
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Influenza Virus Research Studies
- Streptococcal Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory viral infections research
- Antifungal resistance and susceptibility
- Infective Endocarditis Diagnosis and Management
- Hepatitis B Virus Studies
- Legionella and Acanthamoeba research
- Vaccine Coverage and Hesitancy
- Mycobacterium research and diagnosis
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Hepatitis C virus research
- Tuberculosis Research and Epidemiology
- Hepatitis Viruses Studies and Epidemiology
Korea University
2016-2025
International Vaccine Institute
2024-2025
Korea University Medical Center
2002-2023
Wonju Severance Christian Hospital
2023
Yonsei University
2023
National Health Insurance Service Ilsan Hospital
2020
Hanyang University
2020
Ulsan College
2016
University of Ulsan
2016
Korea Center for Disease Control and Prevention
2015
BackgroundVaccination has helped to mitigate the COVID-19 pandemic. Ten traditional and novel vaccines have been listed by World Health Organization for emergency use. Additional alternative approaches may better address ongoing vaccination globally, where there remains an inequity in vaccine distribution. GBP510 is a recombinant protein vaccine, which consists of self-assembling, two-component nanoparticles, displaying receptor-binding domain (RBD) highly immunogenic array.MethodsThis...
Dead and dying cells release nucleic acids. These extracellular RNAs DNAs can be taken up by inflammatory activate multiple acid-sensing toll-like receptors (TLR3, 7, 8, 9). The inappropriate activation of these TLRs engender a variety autoimmune diseases. redundancy the TLR family encouraged us to seek materials that neutralize proinflammatory effects any acid regardless its sequence, structure or chemistry. Herein we demonstrate certain acid-binding polymers inhibit all irrespective...
To evaluate the clinical outcome and predictive factors of recurrence among patients with Kikuchi's disease.Between January 2001 December 2006, all disease were included in study. Data collected on co-morbidities, manifestations, ultrasound/laboratory findings, differences compared between recurrent non-recurrent groups.The study 102 a mean age 26.7 years. Among these patients, three developed systemic lupus erythematosus during follow-up period, while two cases later associated...
ObjectivesThe high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) coupled with an increase in vancomycin use have induced tolerance MRSA, adversely affecting the outcome MRSA bacteraemia. This study aimed to identify predictors persistent bacteraemia (PMRSAB) patients treated vancomycin.
To evaluate the effects of transfusions in patients with severe sepsis and septic shock on mortality.Propensity-matched analysis a prospective observational database (April 2005 to February 2009).Twenty-two medical surgical intensive care units 12 teaching hospitals Korea.One thousand fifty-four community-acquired shock.None.Of 1,054 patients, 407 (38.6%) received blood transfusion. The mean pretransfusion hemoglobin level was 7.7 ± 1.2 g/dL. Transfused had higher 28-day in-hospital...
Abstract Background Despite the increasing popularity of acupuncture, importance infection control is not adequately emphasized in Oriental medicine. In December 2001, an medical doctor Seoul, South Korea, encountered several patients with persistent, culture-negative skin lesions on trunk and extremities at sites prior acupuncture treatment. We identified investigated outbreak Mycobacterium abscessus cutaneous among who attended this medicine clinic. Methods Patients were defined as clinic...
Mixed Candida/bacterial bloodstream infections (BSIs) have been reported to occur in more than 23% of all episodes candidaemia. However, the clinical implications mixed BSIs are not well known. We performed a retrospective case-control study consecutive patients with candidaemia over 5-year period determine risk factors for and outcomes (cases) compared monomicrobial (controls). Thirty-seven (29%) out 126 met criteria cases. Coagulase-negative staphylococci were predominant bacteria (23%) In...
The time to positivity (TTP) of blood cultures is associated with the microbial load in and prognosis patients bloodstream infections caused by various bacterial species. However, relevant information about TTP for Candida species candidaemia limited. We investigated clinical impact on mortality candidaemia.All consecutive ≥ 18 years age between January 2006 July 2012 were included. demographics, microbiological characteristics, antifungal treatment outcomes collected retrospectively.A total...
This study determined the trends in quantities and patterns of nationwide antibiotic consumption Republic Korea (ROK). descriptive epidemiological was conducted ROK between 2008 2012. The total systemic prescriptions were analyzed using National Health Insurance claims data collected through Review Assessment service. Data concerning antibiotics measurement units defined daily dose (DDD) per 1000 people day according to Anatomical Therapeutic Chemical classification. Over 5-year period,...
University Hospitals in KoreaA prospective multicenter observational study was performed to investigate the epidemiology and outcomes of community-acquired severe sepsis septic shock.Subjects included 1,192 adult patients admitted 22 participating intensive care units (ICUs) 12 university hospitals Korean Sepsis Registry System from April, 2005 through February, 2009.Male accounted for 656 (55%) patients.Mean age 65.0 ± 14.2 yr.Septic shock developed 740 (62.1%) patients.Bacteremia present...
To overcome increasing bacterial resistance to conventional antibiotics, many antimicrobial peptides (AMPs) derived from host defense proteins have been developed. However, there are considerable obstacles their application systemic infections because of low bioavailability. In the present study, we developed an AMP Romo1 (AMPR-11) that exhibits a broad spectrum activity. AMPR-11 showed remarkable efficacy against sepsis-causing bacteria, including multidrug-resistant strains, with toxicity...
We investigated the Pseudomonas aeruginosa (PA) outer membrane vesicles (OMVs) and their effect on Acinetobacter baumannii (AB) growth in vitro. The inhibitory effects of PA AB were assessed using a cross-streak assay. OMVs extracted through high-speed centrifugation, tangential flow filtration, ultracentrifugation characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), transmission electron microscopy (TEM), nanoparticle tracking assays (NTAs). Proteomic...
In the 2023-2024 season, influenza epidemic in South Korea peaked earlier than recent years. this study, we aimed to estimate interim vaccine effectiveness (VE) of vaccination prevent during early season. From November 1, 2023, December 31, enrolled 2,632 subjects with influenza-like illness from eight hospitals participating hospital-based morbidity and mortality surveillance. A retrospective test-negative case-control study was conducted VE. The results showed an adjusted VE 22.5% (95%...
Background:In many parts of Asia, the inaccessibility and high cost diagnostic tests have hampered study community-acquired pneumonia (CAP) caused by atypical respiratory pathogens.Objective:This surveillance examined frequency infection with Mycoplasma pneumoniae, Chlamydophila Legionella pneumophila in 1756 patients presenting signs symptoms CAP at 12 medical centres using standardised laboratory techniques interpretation criteria all participating centres.Methods:Diagnosis current was...
ABSTRACT The purpose of this study was to compare the clinical efficacy and safety vancomycin those teicoplanin for treatment adult patients with health care-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) bacteremia. A multicenter observational prospectively conducted in 15 teaching hospitals Korea between February 2010 July 2011. Adult (≥18 years old) HA-MRSA bacteremia who were initially treated (VAN) ( n = 134) or (TEC) 56) enrolled. Clinical microbiological responses...
Abstract Background Streptococcus pneumoniae causes a broad spectrum of illnesses ranging from mild upper respiratory tract infections to invasive pneumococcal disease (IPD). Quantitative data on the burden disease, important for establishment appropriate vaccination strategies, is currently lacking in adults. Methods This multicenter, retrospective cohort study was designed estimate clinical and economic IPD adults over last decade. Data were collected patients with at 10 university...
Hospital-based surveillance for adverse events was conducted on healthcare workers after they received the first dose of coronavirus disease 2019 (COVID-19) vaccine. Among two new platform vaccines (messenger RNA- and adenoviral vector-based vaccines), rates systemic were significantly higher among adenovirus-vectored vaccine recipients. Fatigue (87.6% vs. 53.8%), myalgia (80.8% 50.0%), headache (72.0% 28.8%), fever (≥ 38.0°C, 38.7% 0%) most common recipients, but symptoms resolved within 2...
Abstract We investigated the in vitro activity of various antimicrobial combinations against carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. The six two-drug CRAB isolates collected from blood samples patients with bloodstream infection was evaluated using checkerboard method and time-kill assay [0.5 ×, 1 2 × minimum inhibitory concentration (MIC)] to identify potential synergistic bactericidal effects meropenem, colistin, tigecycline, rifampin, ceftolozane/tazobactam were...