A5100752488- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Influenza Virus Research Studies
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Viral-associated cancers and disorders
- Salmonella and Campylobacter epidemiology
- Herpesvirus Infections and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Animal Virus Infections Studies
- Pneumonia and Respiratory Infections
- Virology and Viral Diseases
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Bacterial Infections and Vaccines
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Vaccine Coverage and Hesitancy
- Virus-based gene therapy research
- Food Allergy and Anaphylaxis Research
- Bartonella species infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacillus and Francisella bacterial research
Keimyung University
2001-2023
SK Group (South Korea)
2016-2023
International Vaccine Institute
2023
Yonsei University
2023
Kangwon National University
2023
Inje University Haeundae Paik Hospital
2021
Inje University
2021
SK Life Science (United States)
2019
University of Ulsan
2017
Asan Medical Center
2017
BackgroundVaccination has helped to mitigate the COVID-19 pandemic. Ten traditional and novel vaccines have been listed by World Health Organization for emergency use. Additional alternative approaches may better address ongoing vaccination globally, where there remains an inequity in vaccine distribution. GBP510 is a recombinant protein vaccine, which consists of self-assembling, two-component nanoparticles, displaying receptor-binding domain (RBD) highly immunogenic array.MethodsThis...
A retrospective clinicopathologic study of lymphoblastic lymphoma was based on 95 patients from the files Repository Center for Lymphoma Clinical Studies. All were treated according to different protocols Cooperative Oncology groups sponsored by National Cancer Institute. The ranged in age 4 84 years, with a median 30 years. Sixty-eight male and 27 female, respective ages 50 male-to-female ratio 2.5:1. Forty had mediastinal masses; (75%) whom male. survival all 17 months (range 1–100...
Nodular lymphomas and diffuse of corresponding cellular composition have been shown to arise from follicular center cells. This paper describes a rare functional morphological expression malignant arising cells, namely, immunoglobulin production, an observation for which no detailed description or nanlysis is available in the literature. Furthermore, unusual signet ring-like appearance lymphoma due retention immunoglobulins within cytoplasm, may result erroneous interpretation metastatic...
The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that lower in the obese than non-obese. Here, we examined influence of on influenza vaccination using high fat diet (HFD) regular (RFD) mice were immunized with 2 types virus vaccines—cell culture-based vaccines egg-based vaccines. HFD showed levels neutralizing antibody titers as compared RFD mice. Moreover, MCP-1 serum adipocytes, low level virus-specific effector memory CD8+ T cells....
Intracranial heterotransplantation in the nude, athymic mouse has been found to be an effective method for experimental growth of human malignant lymphomas. Transplants 11 primary lymphomas and six derived cell lines yielded a high take rate (90%) low mean latent period (36 days). Relatively small inocula produced extensive intracerebral infiltrates which could identified as origin by immunofluorescence. Although confined central nervous system meninges, tumors were highly invasive displayed...
Detailed pathologic and clinical findings in 19 patients with malignant lymphoma a high content of epithelioid histiocytes (MLEH) are presented. The essential morphologic features for inclusion this study comprised diffuse architectural pattern; obliteration normal nodal architecture; small, poorly defined clusters cells scattered throughout the stroma; proliferation atypical small large lymphoid varying proportions. Males predominated patients' ages ranged from 23 to 75 years, median age 49...
A retrospective study was undertaken reviewing records of all children seen in the Division Radiation Therapy at Stanford University Hospital between 1961 and 1971 with a diagnosis non-Hodgkin's lymphoma. Of 41 patients who had been originally diagnosed as having lymphoma, confirmed only 32. Two cases were interpreted malignant histiocytosis, 7 other Hodgkin's disease. 32 but 1 lymphoma diffuse type, histiocytic being most common histologic diagnosis. Lymphangiography attempted patient....
A previously unknown SARS-CoV-2 vaccine protecting nonhuman primates from challenge was developed using RBD-P2 and N.
Abstract Despite the availability of several effective SARS-CoV-2 vaccines, additional vaccines will be required for optimal global vaccination. In this study, we investigate immunogenicity and protective efficacy GBP510 protein subunit vaccine adjuvanted with AS03, which has recently been authorized marketing in South Korea under trade name SKYCovione TM . The antigen GBP510/AS03 is a two-part recombinant nanoparticle, displays 60 receptor binding domain (RBD) proteins Spike on its surface....
In order to investigate the natural history of so-called "Lennert's lymphoma" and reevaluate whether non-Hodgkin's lymphoma with a high content epithelioid histiocytes represents clinicopathologic entity, we reviewed histopathologic clinical features 60 patients in whom pretreatment diagnostic tissues had shown diffuse florid histiocytic reaction identical that originally described by Lennert Mestdagh. Our study indicates is heterogeneous group disorders, which, our series, included...
In 15 patients with lymphoproliferative diseases of various types, histologic studies suggested monoclonal gammopathy. This was confirmed immunoelectrophoretically in the serum, urine, or both, from 10 patients. Seven these had IgM (kappa), one (lambda), IgA and Bence Jones (lambda). Of other five patients, three polyclonal elevations two no detectable immunoglobulin abnormalities. Nuclear periodic acid-Schiff positive globules, heretofore considered to be characteristic macroglobulinemia...
Typhoid fever is an endemic disease in many low-income and middle-income countries. The 2018 WHO position paper recommends that countries should consider typhoid vaccination high-risk groups for outbreak control. To address the vaccine supply demand gap, a Vi polysaccharide-diphtheria toxoid (Vi-DT) conjugate development effort was undertaken to achieve prequalification contribute global of vaccine. main aim this study show immune non-inferiority Vi-DT compared with prequalified...
Korean manufacturers have developed a new varicella vaccine, NBP608. This phase 3, randomized, double-blind, multicenter study aimed to compare the immunogenicity and safety of NBP608 in healthy children those VarivaxTM (control). Children aged 12 months years were randomized ratio 1:1 receive either or control vaccine. Serum samples obtained before vaccination within six eight weeks after vaccination. In total, 499 participants (NBP608, n = 251; control, 248) enrolled. The seroconversion...
This report covers the topics of pandemics, epidemics and partnerships, including regulatory convergence initiatives, new technologies novel vaccines, discussed by leading public private sector stakeholders at 18th Annual General Meeting (AGM) Developing Countries Vaccine Manufacturers' Network (DCVMN). Contributions Gavi vaccine industry from emerging countries to growing global market, improving supply base manufacturers in developing contributing 58% doses, were highlighted. The Coalition...
Typhoid fever remains an important public health problem in developing countries and is endemic many parts of Asia Africa where the incidence disease typically peaks school-aged children. Age restrictions other limitations existing oral live-attenuated typhoid parenteral Vi polysaccharide vaccines have triggered development conjugate with improved immunological properties, use younger age range, longer durability protection. We present safety, reactogenicity, immunogenicity data from a Phase...
When influenza viruses are cultured in eggs, amino acid mutations of the hemagglutinin may occur through egg adaptation. On other hand, when animal cells, no antigenic mutation occurs unlike eggs. Therefore, we examined whether actually occurred after passage H3N2 (A/Texas/50/2012) virus up to 15 times eggs and MDCK-Sky3851 cells.Prototype A/Texas/50/2012 (H3N2) which was isolated from clinical patient, not passaged egg, obtained propagated using specific pathogen free cell line passage,...
ABSTRACT Background GBP510 vaccine contains self-assembling, recombinant nanoparticles displaying SARS-CoV-2 spike receptor-binding domains. We report interim phase 3 immunogenicity results for adjuvanted with AS03 (GBP510/AS03) compared ChAdOx1-S (Vaxzevria, AstraZeneca) up to 2 weeks after the second dose, and safety data a median of 2.5 months follow-up. Methods Randomised, active-controlled, observer-blinded, multinational study: Cohort 1 (no history infection/COVID-19 vaccination,...