A5002381892- Education and Learning Interventions
- Mosquito-borne diseases and control
- Psychosocial Factors Impacting Youth
- Cancer Genomics and Diagnostics
- Cardiac Valve Diseases and Treatments
- Sepsis Diagnosis and Treatment
- Malaria Research and Control
- Atrial Fibrillation Management and Outcomes
- Protein purification and stability
- Immune Cell Function and Interaction
- Venous Thromboembolism Diagnosis and Management
- Analytical Chemistry and Chromatography
- Clinical Laboratory Practices and Quality Control
- Gene expression and cancer classification
- HIV Research and Treatment
- Renal and related cancers
- Antioxidant Activity and Oxidative Stress
- Healthcare Education and Workforce Issues
- Dialysis and Renal Disease Management
- Immune cells in cancer
- Electrochemical sensors and biosensors
- Metabolomics and Mass Spectrometry Studies
- HIV/AIDS drug development and treatment
- Bacterial Identification and Susceptibility Testing
- BRCA gene mutations in cancer
Michigan Technological University
2022-2024
Children's National
2014-2024
Yonsei University
2012-2023
Severance Hospital
2016-2023
Bio-Medical Science (South Korea)
2022
Radboud University Nijmegen
2021
University of Ulsan
2019-2020
Asan Medical Center
2007-2020
Ulsan College
2019-2020
Kangwon National University
2020
The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that lower in the obese than non-obese. Here, we examined influence of on influenza vaccination using high fat diet (HFD) regular (RFD) mice were immunized with 2 types virus vaccines—cell culture-based vaccines egg-based vaccines. HFD showed levels neutralizing antibody titers as compared RFD mice. Moreover, MCP-1 serum adipocytes, low level virus-specific effector memory CD8+ T cells....
Apigenin (5,7,4′-trihydroxyflavone) is a principal ingredient of Cirsium japonicum. These experiments were performed to determine whether apigenin has neuroprotective effects against kainic acid (KA)-induced excitotoxicity in vitro and vivo. Intraperitoneal (i.p.) administration (25, 50 mg/kg) decreased the seizure scores induced by KA injection (40 mg/kg, i.p.) mice. In addition, convulsion onset time was significantly delayed administration. Moreover, we found that blocked KA-induced...
The Republic of Korea experienced a re-emergence Plasmodium vivax malaria in 1993. incidence this disease increased rapidly through 2000 with its geographic distribution expanding from the vicinity near Demilitarized Zone to adjacent outlying areas. However, number cases P. since that time period has decreased. A total 2,538 occurred 2001, and decreased 1,761 1,164 two subsequent years. 5,463 were reported 2001 2003; 25.26% (1,380) among military personnel, 27.48% (1,501) veterans who had...
Vivax malaria re-emerged in the Republic of Korea (ROK) 1993. The annual incidence this disease, which had increased rapidly through 2000 with geographic expansion, started to decrease 2001, reaching 864 cases 2004; however, trends changed 2005 when 1,304 were reported. Among 2,168 vivax reported from 2004 2005, 389 (17.9%) ROK military personnel, 565 (26.1%) veterans who been discharged within 2 years report infection, and 1,214 (56.0%) civilians. Local transmission might have taken place...
The retention behavior of star-shaped polystyrene (PS) at the liquid chromatographic critical condition linear PS was investigated. samples were prepared by anionic polymerization styrene and subsequent linking polystyryl anions with divinylbenzene. reaction yields a series different number branches equal length. Three arm molecular weight (MW) prepared. To investigate MW (hence branch number) dependence LCCC (liquid chromatography condition) retention, two-dimensional method used—first...
Acute kidney injury (AKI) following sepsis is associated with higher mortality; however, reliable biomarkers for AKI development and recovery remain to be elucidated.Patients admitted the medical intensive care unit (ICU) of Severance Hospital between June 2018 May 2019 were prospectively analyzed. Patients divided into those without within 48 hours. septic subdivided AKI-recovery non-recovery groups based on whether their recovered 7 days.A total 84 patients enrolled. The baseline...
Device-related thrombosis (DRT) occurs in up to 4% of patients undergoing left atrial appendage occlusion (LAAO) and is associated with substantial morbidity mortality. However, its pathophysiology, predictors, optimal management remain unclear.
Department of Laboratory Medicine and Research Institute Bacterial Resistance, Yonsei University College Medicine, National Police Hospital, Brain Korea 21 PLUS Project for Medical Science, University, Infection Control, Severance Division Infectious Diseases, Internal Seoul,
The white-rot fungi Ceriporia lacerata is used in bioremediation, such as lignocellulose degradation, nature. Submerged cultures and extracts of C. mycelia (CLM) have been reported to contain various active ingredients, including β-glucan extracellular polysaccharides, exert anti-diabetogenic properties mice cell lines. However, the immunostimulatory effects not yet reported. This study aimed identify immunomodulatory effects, underlying mechanisms thereof, submerged CLM using RAW264.7...
Abstract Background We evaluated the analytical performance of a newly developed electrochemiluminescence immunoassay for everolimus and sirolimus compared to that liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). Methods According Clinical Laboratory Standards Institute guidelines, including precision, recovery, linearity, carryover was evaluated. For correlation evaluation, results Elecsys ® analysis were with those LC‐MS/MS using 120 samples from patients treated or sirolimus....
This experiment was designed to investigate whether 4-O-methylhonokiol (MH), a principal ingredient of Magnolia (M.) officinalis bark, alleviated acute intraperitoneal (i.p.) kainic acid- (KA-) induced brain blood barrier dysfunction (BBBD) via pathological examination and cytological analyses the tissues mice. KA (10–30 mg/kg) time- dose-dependently increased water content edema encephalopathy. However, pretreatment with MH (5 20 mg/kg, i.p.) significantly reduced compared that observed in...
The incidence of polypharmacy-which can result in drug-drug interactions-has increased recent years. Drug-metabolizing enzymes and drug transporters are important polypharmacy modulators. In this study, the effects bosentan rifampin on expression activities organic anion-transporting peptide (OATP) cytochrome P450 (CYP450) 2C9 CYP3A4 were investigated vitro. HEK293 cells primary human hepatocytes overexpressing target genes treated with various concentrations rifampin, which decreased uptake...