A5062914526- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Lung Cancer Research Studies
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Infectious Diseases and Tuberculosis
- Nutrition and Health in Aging
- Neuroendocrine Tumor Research Advances
- Neonatal Respiratory Health Research
- Intensive Care Unit Cognitive Disorders
- Axon Guidance and Neuronal Signaling
- Antibiotic Resistance in Bacteria
- Renal Transplantation Outcomes and Treatments
Yonsei University
2016-2025
Severance Hospital
2016-2025
Korea Pharma (South Korea)
2024
Ewha Womans University
2021-2023
Thales (Portugal)
2021
Yonsei University Health System
2006-2020
ORCID
2019
Pulmonary Associates
2018
Samsung Medical Center
2011-2016
University of Ulsan
2011-2016
The C-reactive protein (CRP)/albumin ratio has recently emerged as a marker for poor prognosis or mortality across various patient groups. This study aimed to identify the association between CRP/albumin and 28-day predict accuracy of in medical intensive care unit (ICU) patients. was retrospective cohort 875 We evaluated prognostic value at 28 days after ICU admission, using Cox proportional hazard model Kaplan-Meier survival analysis. 28.0%. In univariate analysis, Acute Physiology Chronic...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a rare, irreversible, and progressive disease of the lungs. Common genetic variants, in addition to nongenetic factors, have been consistently associated with IPF. Rare variants identified by candidate gene, family-based, exome studies also reported associate However, extent which rare genome-wide, may contribute risk IPF remains unknown. Objectives: We used whole-genome sequencing investigate role on risk. Methods: As part Trans-Omics for...
Epidemic outbreaks of multi-drug resistant (MDR) Acinetobacter baumannii (AB) in intensive care units (ICUs) are increasing. The incidence MDR AB bacteremia, which develops as a result colonization, is increasing through widespread dissemination the pathogen, and further colonization. We sought to determine risk factors for bacteremia patients colonized with ICU.We conducted retrospective, observational study 200 ICU at Severance Hospital, South Korea during outbreak period between January...
This study was designed to evaluate the efficacy and toxicity of erlotinib in patients with advanced non-small-cell lung cancer (NSCLC) who experienced disease progression after treatment gefitinib.The included stage IIIB/IV recurrent or metastatic NSCLC received two three prior chemotherapy regimens showed progressive within 4 months gefitinib therapy discontinuation. Patients 150 mg/d until unacceptable toxicity. Epidermal growth factor receptor (EGFR) mutations other genetic abnormalities...
Diffuse alveolar hemorrhage (DAH) is a life-threatening and medical emergency that can be caused by numerous disorders presents with hemoptysis, anemia, diffuse infiltrates. Early bronchoscopy bronchoalveolar lavage usually required to confirm the diagnosis rule out infection. Most cases of DAH are capillaritis associated systemic autoimmune diseases such as anti-neutrophil cytoplasmic antibody-associated vasculitis, anti-glomerular basement membrane disease, lupus erythematosus, but may...
Abstract Background The immature granulocyte count has been reported to be a marker of infection and sepsis. difference in leukocyte subfractions (delta neutrophil index, DNI) ADVIA 2120 reflects the fraction circulating granulocytes blood. This study evaluated clinical utility DNI as severity prediction critically ill patients with Methods One hundred three admitted medical intensive care unit sepsis were studied. (the identified by myeloperoxidase nuclear lobularity channels) was...
Sarcopenia can contribute to negative outcomes in patients with various lung diseases. However, whether sarcopenia affects prognosis idiopathic pulmonary fibrosis (IPF) has not been reported. Simple measures of muscle mass, derived from chest computed tomography (CT), are increasingly being used identify sarcopenia. We hypothesized that skeletal mass could be a predictor IPF patients.We retrospectively evaluated 180 diagnosed between January 2010 and December 2015 at tertiary care hospital...
Despite extensive research and an improved standard of care, sepsis remains a disorder with high mortality rate. Sepsis is accompanied by severe metabolic alterations.We evaluated 117 patients (severe [n = 19] septic shock 98]) who were admitted to the intensive care unit. Serum cholesterol, triglyceride (TG), high-density lipoprotein (HDL), low-density (LDL), free fatty acid (FFA), apolipoprotein (Apo) A-I levels measured on days 0, 1, 3, 7.Nonsurvivors had low TG, HDL, LDL, Apo 7. In...
Purpose: Acute kidney injury (AKI) is common in critically ill patients.Serum cystatin C has emerged as a reliable marker of AKI.We sought to assess the value serum for early detection and prediction renal function recovery patients with sepsis.Materials Methods: Sepsis (113 AKI 49 non-AKI patients) admitted intensive care unit (ICU) were included.Serum creatinine levels glomerular filtration rate measured on days 0, 1, 3, 7. Results: Serum significantly higher than at all time...
Abstract Background Lung cancer is the primary cause of cancer-related deaths worldwide. The human lung serves as a niche to unique and dynamic bacterial community that related development multiple diseases. Here, we investigated differences in microbiomes patients with cancer. Methods 16S rRNA sequencing was performed evaluate respiratory tract microbiome present bronchoalveolar lavage fluid. Patients were stratified based on programmed death-ligand 1 (PD-L1) expression levels immunotherapy...
Abstract Background Interferon-γ release assay (IGRA) may improve diagnostic accuracy for latent tuberculosis infection (LTBI). This study compared the performance of tuberculin skin test (TST) with that IGRA diagnosis LTBI in immunocompromised patients an intermediate TB burden country where BCG vaccination is mandatory. Methods We conducted a retrospective observational given TST and IGRA, QuantiFERON-TB Gold In-Tube (QFT-IT), at Severance Hospital, tertiary hospital South Korea, from...
Abstract Purpose: This study aimed to search for predictors of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) efficacy in previously treated patients with advanced squamous cell lung carcinoma which EGFR mutations are very rare. Experimental Design: gene copy numbers were assessed by FISH and evaluated as EGFR-TKI 71 cancer who received gefitinib or erlotinib a second-line higher therapy. The tumors classified into EGFR/FISH-positive (high polysomy/gene...
The clinical course of idiopathic pulmonary fibrosis (IPF) varies widely. Although the GAP model is useful for predicting mortality, survivals have not yet been validated each score. We aimed to elucidate how prognosis related score and stage in IPF patients. Korean Interstitial Lung Disease Study Group conducted a national survey evaluate various characteristics patients from 2003 2007. Patients were diagnosed according 2002 criteria ATS/ERS. enrolled 1,685 with IPF; 1,262 had undergone...
Pneumocystis jirovecii pneumonia (PJP) is a potentially life-threatening infection that occurs in immunocompromised patients. The aim of this study was to evaluate risk factors for PJP kidney transplantation recipients. We conducted retrospective analysis patient data from 500 consecutive transplants performed at Severance Hospital between April 2011 and 2014. Eighteen recipients (3.6%) were diagnosed with PJP. In the univariate analysis, acute graft rejection, CMV infection, use medication...
Abstract Interstitial lung disease (ILD), particularly idiopathic pulmonary fibrosis (IPF), has a poor prognosis. Corticosteroids are widely used in the treatment of acute exacerbation ILD (AE-ILD). This study aimed to clarify causes AE-ILD, determine efficacy corticosteroids for treating and detect differences mortality rate among subgroups ILD. was an observational retrospective single-center study. Patients with who presented emergency department respiratory symptoms from January 1, 2016,...
The longitudinal relationship between adiposity and lung function is controversial. We aimed to investigate the long-term association changes in a middle-aged general Asian population.In total, 5011 participants (average age, 54 years; 45% men) were enrolled from community-based prospective cohort. During follow-up period (median 8 years), both spirometry bio-electrical impedance analysis performed biannually. Individual slopes of fat mass index (FMI; divided by square height meters)...