Masaki Hirose
A5011104962- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Medical Imaging and Pathology Studies
- Tuberous Sclerosis Complex Research
- Photonic and Optical Devices
- Semiconductor Lasers and Optical Devices
- Congenital Diaphragmatic Hernia Studies
- Eosinophilic Disorders and Syndromes
- Inhalation and Respiratory Drug Delivery
- Pulmonary Hypertension Research and Treatments
- Optical Network Technologies
- Sarcoidosis and Beryllium Toxicity Research
- Transcranial Magnetic Stimulation Studies
- Histiocytic Disorders and Treatments
- Advancements in Semiconductor Devices and Circuit Design
- Vascular Tumors and Angiosarcomas
- Semiconductor Quantum Structures and Devices
- Algal biology and biofuel production
- Semiconductor materials and devices
- Mesoporous Materials and Catalysis
- Immune Cell Function and Interaction
- Corporate Governance and Law
- Respiratory viral infections research
- Helicobacter pylori-related gastroenterology studies
- Photonic Crystals and Applications
National Kinki Chuo Hospital for Chest Disease
2016-2025
Rakuno Gakuen University
2024
Chiba University
2019-2024
Dokkyo Medical University
2023
Kyoto University
2022
Osaka Women's and Children's Hospital
2022
Neurology, Inc
2021
Saitama Institute of Technology
2020
Green Chemistry
2020
RIKEN Center for Brain Science
2020
Rationale: Idiopathic pulmonary fibrosis (IPF) is a rare, irreversible, and progressive disease of the lungs. Common genetic variants, in addition to nongenetic factors, have been consistently associated with IPF. Rare variants identified by candidate gene, family-based, exome studies also reported associate However, extent which rare genome-wide, may contribute risk IPF remains unknown. Objectives: We used whole-genome sequencing investigate role on risk. Methods: As part Trans-Omics for...
Rationale: Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung.Objectives: To develop an integrated understanding of located in multiple loci reported contribute risk disease.Methods: We performed deep targeted resequencing (3.69 Mb DNA) cases (n = 3,624) control subjects 4,442) across genes regions previously disease. tested for associations between disease 1) individual via logistic...
Abstract Idiopathic pulmonary fibrosis is an incurable disease of unknown etiology. Acute exacerbation idiopathic associated with high mortality. Excessive apoptosis lung epithelial cells occurs in acute exacerbation. We recently identified corisin, a proapoptotic peptide that triggers fibrosis. Here, we provide insights into the mechanism underlying processing and release corisin. Furthermore, demonstrate anticorisin monoclonal antibody ameliorates by significantly inhibiting human...
Aberrant immune responses to viral pathogens contribute pathogenesis, but our understanding of pathological caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019...
By using human T-cell growth factor (TCGF), 10 cell lines were established from tissue samples of patients with adult leukemia (ATL). Three adapted to in medium lacking TCGF. The surface markers all characteristic inducer/helper T cells, i.e., OKT3+, OKT4+, OKT6-, OKT8-, OKIa1+, and Lyt2+ Lyt3+, except that one line was OKT3-. expression the viral antigen examined during establishment 8 lines. not expressed leukemic cells before cultivation. In 5 lines, detected by immunofluorescent staining...
We studied the relationship between mitochondrial density in cells and cellular sensitivity to toxicity of cis-diaminedichloroplatinum II (cisplatin), a potent anticancer agent. Biochemical analyses revealed that mitochondria intestinal epithelium changed markedly along its entire length. The was highest at duodenum, medium jejunum, lowest ileum. epithelial cisplatin ileum as judged from occurrence apoptosis. Similar correlation also observed with vitro experiments, which (IEC-6) their ρ 0...
Abstract Short-wavelength (blue-violet-to-green) lasers with high power and beam quality are required for various applications including the machining of difficult-to-process materials high-brightness illuminations displays. Promising light sources such wide-bandgap GaN-based photonic-crystal surface-emitting (PCSELs), which based on two-dimensional resonance in photonic crystal. Developments these devices have lagged behind those longer-wavelength GaAs-based PCSELs, because device designs...
Although no report has demonstrated the efficacy of corticosteroid therapy for autoimmune pulmonary alveolar proteinosis (aPAP), we sometimes encounter patients who have received this various reasons. However, as corticosteroids can suppress macrophage function, might worsen disease severity and increase risk infections. For retrospective cohort study, sent a screening form to 165 institutions asking information on aPAP treated with corticosteroids. Of resulting 45 screened, 31 were enrolled...
Rationale: Sirolimus has been shown in a randomized, controlled clinical trial to stabilize lung function patients with lymphangioleiomyomatosis (LAM) treated for 12-month time period; however the pretreatment decline after drug was discontinued indicated that continued exposure is required suppress disease progression.Objectives: To elucidate durability and tolerability of long-term sirolimus treatment Asian LAM.Methods: We conducted single-arm, open-label, investigator-initiated safety...
Abstract Pulmonary alveolar proteinosis (PAP) is a devastating lung disease caused by abnormal surfactant homeostasis, with prevalence of 6–7 cases per million population worldwide. While mutations causing hereditary PAP have been reported, the genetic basis contributing to autoimmune (aPAP) has not thoroughly investigated. Here, we conducted genome-wide association study aPAP in 198 patients and 395 control participants Japanese ancestry. The common variant, rs138024423 at 6p21,...
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare smoking-related lung disease characterized by dendritic (DC) accumulation, bronchiolocentric nodule formation, and cystic remodeling. Approximately 50% of patients with PLCH harbor somatic BRAF-V600E mutations in cells the myeloid/monocyte lineage. However, rarity lack animal models have impeded study pathogenesis. Here, we establish cigarette smoke–exposed (CS-exposed) BRAF-V600E–mutant mouse model that recapitulates many hallmark...
To elucidate the still unclear mechanism of delayed encephalopathy after carbon monoxide (CO) poisoning, we serially performed single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) and diffusion tensor imaging (DTI) on a 3.0T system intelligence tests in 2 patients, while they were undergoing hyperbaric oxygenation therapy. The chronological changes (1)H-MRS- DTI-derived parameters indicated following: (1) White matter demyelination, aerobic metabolism inhibition, cytotoxic edema...
The effects of phenobarbital (PB), polychlorinated biphenyl (PCB) and sodium saccharin (SS) on hepatic renal carcinogenesis induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) were examined in male F344 rats. rats given 0.1% EHEN their drinking water for 2 weeks then diet containing 0.05% PB, PCB or 5% SS 32 weeks. In week 3, the right kidney was removed to promote neoplasia. incidence hepatocellular carcinoma much higher PB than controls alone. administration significantly decreased average...
Serum markers, including Krebs von den Lungen (KL-6), surfactant protein (SP)-D, SP-A and carcinoembryonic antigen (CEA), are reported to reflect autoimmune pulmonary alveolar proteinosis (APAP) disease severity. We evaluated serum CYFRA21-1 levels as a marker of APAP.In addition KL-6, SP-D CEA, we prospectively measured CYFRA 21-1 in 48 patients with APAP, consecutively diagnosed between 2002 2010. Diagnostic usefulness was determined from 68 interstitial lung diseases by receiver operator...
Background In lymphangioleiomyomatosis (LAM), tuberous sclerosis gene mutations activate the mechanistic target of rapamycin pathway, resulting in vascular endothelial growth factor-D (VEGF-D) overproduction. While utility serum VEGF-D testing for diagnosis LAM is outlined ATS/JRS Guidelines, assay has not been fully validated Asian populations. Our aims were to validate Japan, by directly comparing measurements Japan and U.S., determining diagnostic cut-off levels among Japanese women with...
The effect of intraoviductal embryos on endometrial receptivity was studied by intraendometrial and intrauterine embryo transfer. Five-week-old female ICR mice were mated after superovulation; a vaginal plug confirmed day 1 pregnancy. On 4 (90 h hCG injection), blastocysts collected transferred to pseudopregnant recipient in which the uterotubal junction had been ligated bilaterally Three per uterine horn, total six mouse at days 1–6, endometrium or cavity implantation pregnancy rates...
Abstract Background: Helicobacter pylori infection has been reported to cause gastroduodenal ulcer, mucosa‐associated lymphoid tissue lymphoma, and gastric cancer. Recent studies have suggested that H. may also associate with other diseases, including hematologic dermatologic disorders, cardiovascular injury, by unknown mechanisms. Methods: Production of reactive oxygen species (ROS) was determined in peripheral blood samples from 86 patients (34 ‐negative 52 ‐positive subjects) using a...