A5052991308- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Nerve injury and regeneration
- Fibroblast Growth Factor Research
- Adipose Tissue and Metabolism
- Liver physiology and pathology
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Phagocytosis and Immune Regulation
- Pancreatic function and diabetes
- Kruppel-like factors research
- Pancreatitis Pathology and Treatment
- Peroxisome Proliferator-Activated Receptors
- Periodontal Regeneration and Treatments
- Metabolism, Diabetes, and Cancer
- Interconnection Networks and Systems
- Laser Applications in Dentistry and Medicine
- Genomics, phytochemicals, and oxidative stress
- Barrier Structure and Function Studies
- Connective Tissue Growth Factor Research
- Lipid metabolism and biosynthesis
- Toxic Organic Pollutants Impact
Columbia University Irving Medical Center
2020-2024
University of Louisville
2016-2024
Columbia University
1990-2022
Wenzhou Medical University
2012-2021
Northwestern University
2019
Shiga University of Medical Science
1999
Hypertrophic scars (HTS) and keloids are challenging problems. Their pathogenesis results from an overproduction of fibroblasts excessive deposition collagen. Studies suggest a possible anti-scarring effect basic fibroblast growth factor (bFGF) during wound healing, but the precise mechanisms bFGF still unclear. In view this, we investigated therapeutic effects on HTS animal model as well human scar (HSF) model. We show that promoted healing reduced area flattened non-pathological in rat...
Growth factors are involved in the regulation of hair morphogenesis and cycle growth. The present study sought to investigate growth promoting activities three approved factor drugs, fibroblast 10 (FGF-10), acidic (FGF-1), basic (FGF-2), mechanism action. We observed that FGFs promoted by inducing anagen phase telogenic C57BL/6 mice. Specifically, histomorphometric analysis data indicates topical application induced an earlier prolonged mature phase, contrast control group. Moreover,...
Summary Aim To investigate the mechanism of endoplasmic reticulum (ER) stress–induced apoptosis as well protective action basic fibroblast growth factor ( bFGF ) both in vivo and vitro . Methods Results ER was involved injuries spinal cord injury (SCI) model rat. administration improved recovery increased survival neurons lesions The effect is related to inhibition CHOP, GRP78 caspase‐12, which are response proteins. also expression growth‐associated protein 43 (GAP43), neural regeneration....
Endoplasmic reticulum (ER) stress-induced apoptosis plays a major role in various diseases, including spinal cord injury (SCI). Nerve growth factor (NGF) show neuroprotective effect and improve the recovery of SCI, but relations ER NGF therapeutic SCI still unclear. Young adult female Sprague-Dawley rats's vertebral column was exposed laminectomy done at T9 vertebrae moderate contusion injuries were performed using vascular clip. stock solution diluted with 0.9% NaCl administered...
Effective wound healing requires complicated, coordinated interactions and responses at protein, cellular, tissue levels involving growth factor expression, cell proliferation, closure, granulation formation, vascularization. In this study, we develop a heparin-based coacervate consisting of poly(ethylene argininylaspartate digylceride) (PEAD) as storage matrix, heparin bridge, fibroblast factor-2 (FGF2) cargo (namely heparin-FGF2@PEAD) for healing. First, in vitro characterization...
Abstract Intervertebral disc degeneration (IDD) is a complicated disease in patients. The pathogenesis of IDD encompasses cellular oxidative stress, mitochondrion dysfunction and apoptosis. Melatonin eliminates oxygen free radicals, regulates mitochondrial homoeostasis function, stimulates mitophagy protects against Therefore, we hypothesize that melatonin has beneficial effect on by stimulation inhibition effects were investigated vitro vivo. For the former, diminished apoptosis caused...
Fibrosis contributes to ~45% of deaths in western countries. In chronic liver disease, fibrosis is a major factor determining outcomes, but efficient antifibrotic therapies are lacking. Although platelet-derived growth and transforming factor–β constitute key fibrogenic mediators, they do not account for the well-established link between cell death liver. Here, we hypothesized that damage-associated molecular patterns (DAMPs) may epithelial fibrogenesis injured DAMP receptor screening...
Necroptosis contributes to hepatocyte death in nonalcoholic steatohepatitis (NASH), but the fate and roles of necroptotic hepatocytes (necHCs) NASH remain unknown. We show here that accumulation necHCs human mouse liver is associated with an up-regulation “don’t-eat-me” ligand CD47 on necHCs, not apoptotic hepatocytes, increase receptor SIRPα macrophages, consistent impaired macrophage-mediated clearance necHCs. In vitro, necHC by primary macrophages was enhanced treatment either anti-CD47...
Extensive research focused on finding effective strategies to prevent or improve recovery from myocardial ischaemia/reperfusion (I/R) injury. Basic fibroblast growth factor (bFGF) has been shown have therapeutic potential in some heart disorders, including ischaemic In this study, we demonstrate that bFGF administration can inhibit the endoplasmic reticulum (ER) stress and mitochondrial dysfunction induced a mouse model of I/R vitro, exerts protective effect by inhibiting ER response...
// Zhouguang Wang 1 , Yan Huang Yi Cheng Tan 1,2 Fenzan Wu Jiamin Hongxue Shi Hongyu Zhang Xichong Yu Hongchang Gao Li Lin Jun Cai 2 Jinsan Xiaokun Lu and Jian Xiao Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Science, Key Laboratory Biotechnology Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China Department Pediatrics, Children's Hospital Institute, the University Louisville, Kentucky, USA Correspondence to: Xiao, email: Cai,...
Fibroblasts play a pivotal role in the process of cutaneous wound repair, whereas their migratory ability under diabetic conditions is markedly reduced.In this study, we investigated effect basic fibroblast growth factor (bFGF) on human dermal migration high-glucose environment.bFGF significantly increased by increasing percentage fibroblasts with high polarity index and reorganizing F-actin.A significant increase intracellular reactive oxygen species (ROS) was observed following bFGF...
Background and Aims Fibroblast growth factor (FGF) 1 demonstrated protection against nonalcoholic fatty liver disease (NAFLD) in type 2 diabetic obese mice by an uncertain mechanism. This study investigated the therapeutic activity mechanism of a nonmitogenic FGF1 variant carrying 3 substitutions heparin‐binding sites (FGF1 △HBS ) NAFLD. Approach Results administration was effective 9‐month‐old homozygous mutation leptin receptor gene ( db/db with NAFLD; weight, lipid deposition,...
Background:The unfolded protein response, autophagy and endoplasmic reticulum (ER) stress-induced apoptosis regulate tumor cell fate have become novel signaling targets for the development of cancer therapeutic drugs.Curcumin has been used to treat several different cancers, including ovarian cancer, in clinical trials research; however, role ER stress effects curcumin new analogues remains unclear.Methods: Cell viability was determined using MTT assay.Apoptosis detected flow cytometry with...
Dietary copper-fructose interactions contribute to the development of nonalcoholic fatty liver disease (NAFLD). Gut microbiota play critical roles in pathogenesis NAFLD. The aim this study was determine effect different dietary doses copper and their with high fructose on gut microbiome. Male weanling Sprague-Dawley rats were fed diets adequate (6 ppm CuA), marginal (1.5 CuM) (low copper), or supplemented (20 CuS) (high copper) for 4 wk. Deionized water deionized containing 30% (wt/vol)...
The purpose of this study is to identify an environmentally relevant shared receptor target for endocrine and metabolism disrupting chemical pollutants. A feature the tested chemicals was that they induced Cyp2b10 in vivo implicating activation constitutive androstane (CAR). Recent studies suggest these compounds could be indirect CAR activators via epidermal growth factor (EGFR) inhibition. Assays included a activity reporter assay, EGF endocytosis EGFR phosphorylation assay. Docking...
Pressure ulcer is a complex and significant health problem in long-term bedridden patients, there currently no effective treatment or efficient prevention method. Furthermore, the molecular mechanisms pathogenesis contributing to deep injury of pressure ulcers are unclear. The aim study was explore role endoplasmic reticulum (ER) stress Akt/GSK3β signaling ulcers. A model pressure-induced tissue adult Sprague-Dawley rats established. Rats were treated with 2-h compression subsequent 0.5-h...