A5100401980- Liver Disease Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Lipid metabolism and disorders
- Cytokine Signaling Pathways and Interactions
- Thyroid Cancer Diagnosis and Treatment
- Diet and metabolism studies
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Traditional Chinese Medicine Studies
- Ginseng Biological Effects and Applications
- Hormonal Regulation and Hypertension
- Hormonal and reproductive studies
- Diabetes Management and Research
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Nutritional Studies and Diet
- Thyroid Disorders and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Menopause: Health Impacts and Treatments
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- PI3K/AKT/mTOR signaling in cancer
- Chronic Kidney Disease and Diabetes
Guangzhou University of Chinese Medicine
2022-2025
Ji Hua Laboratory
2025
Guangdong Provincial Hospital of Traditional Chinese Medicine
2025
Sun Yat-sen University
2024
Fudan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2023
Shanghai Institute of Technology
2023
Shanghai Research Institute of Chemical Industry
2023
Southwest Medical University
2022
Objective: The purpose of this study was to evaluate the efficacy and safety sitagliptin as an add-on metformin therapy in patients with moderately severe (hemoglobin A1c ≥ 8.0% ≤ 11.0%) type 2 diabetes mellitus (T2DM).Research design methods: This a multinational, randomized, placebo-controlled, parallel-group, double-blind conducted 190 T2DM. After 6 weeks stable monotherapy (≥ 1500 mg/day), were randomized either addition 100 mg once daily or placebo ongoing for 30 weeks.Main outcome...
Abstract High serum free fatty acid (FFA) levels are associated with metabolic syndrome (MS). This study aimed to assess the association of fasting FFAs nonalcoholic liver disease (NAFLD) in a Chinese population. A total 840 subjects fulfilled diagnostic criteria NAFLD and 331 healthy control participants were enrolled this cross-sectional study. Fasting FFA other clinical laboratory parameters measured. patients had significantly higher than controls ( P < 0.001). Serum positively...
Fibrosis contributes to ~45% of deaths in western countries. In chronic liver disease, fibrosis is a major factor determining outcomes, but efficient antifibrotic therapies are lacking. Although platelet-derived growth and transforming factor–β constitute key fibrogenic mediators, they do not account for the well-established link between cell death liver. Here, we hypothesized that damage-associated molecular patterns (DAMPs) may epithelial fibrogenesis injured DAMP receptor screening...
Dipeptidyl peptidase IV (DPP-4) inhibitors improve glycemic control in patients with type 2 diabetes. The underlying mechanisms (incretin effect, β-cell function, endogenous glucose production) are not well known.The aim of the study was to examine antihyperglycemic effect DPP-4 inhibitors.We administered a mixed meal tracers ([6,6-(2)H(2)]-glucose infused, [1-(2)H]-glucose ingested), and on separate day, infusion matched responses (isoglycemic test) 50 diabetes (hemoglobin A(1c) = 7.4 ±...
Silymarin, salvianolic acids B, and puerarin were considered healthy food agents with tremendous potential to ameliorate non-alcoholic fatty liver disease (NAFLD). However, the mechanisms by which they interact gut microbiota exert benefits are largely unknown. After 8 weeks of NAFLD modeling, C57BL/6J mice randomly divided into five groups fed a normal diet, high-fat diet (HFD), or HFD supplemented medium high dose Silybum marianum extract contained silymarin polyherbal silymarin, for 16...
Metabolic-associated fatty liver disease is common, with fibrosis the major determinant of adverse outcomes. Population-based screening tools high diagnostic accuracy for staging are lacking.Three independent cohorts, 2 both biopsy and stiffness measurements (LSMs, n = 254 65) a population sample (n 713), were studied. The performance recently developed noninvasive algorithm (ADAPT [age, diabetes, PRO-C3 platelets panel]) as well aspartate aminotransferase-to-platelet ratio index,...
Unhealthy lifestyles, obesity, and environmental pollutants are strongly correlated with the development of nonalcoholic fatty liver disease (NAFLD). Haloacetaldehyde-associated disinfection byproducts (HAL-DBPs) at various multiples concentrations found in finished drinking water together high-fat (HF) were examined to gauge their mixed effects on hepatic lipid metabolism. Using new alternative methods (NAMs), studying human cells
The report presents the case of a 70-year-old man with advanced squamous lung cancer who developed dermatologic toxicities after receiving Pembrolizumab-based therapy. During acute phase, patient was treated an integrative treatment glucocorticosteroids and traditional Chinese medicine (TCM) achieved superior efficacy. presented blisters papules distributed covering 60% trunk extremities, along more than 90% coverage hands feet, graded as cutaneous immune-related adverse event (irAE) 3-4...
Abstract A previous study has demonstrated that Ganshuang granule ( GSG ) plays an anti‐fibrotic role partially by deactivation of hepatic stellate cells HSC s). In s activation, mammalian target rapamycin mTOR )‐autophagy important role. We attempted to investigate the ‐autophagy in effect . The cirrhotic mouse model was prepared demonstrate anti‐fibrosis High performance liquid chromatography HPLC analyses were used identify active component primary isolated and naringin added into...
Objective . To explore the effects of N 1 -methylnicotinamide (MNAM) on insulin resistance and glucose metabolism in obese type 2 diabetes mellitus (T2DM) mice regulatory mechanisms NAD-dependent deacetylase sirtuin-1 (SIRT1)/forkhead box protein O1 (FOXO1) pathway. Methods Blood levels were examined mice. HE oil red O staining used to observe MNAM liver lipid deposition ob/ob Real-time PCR Western blotting detect expression gluconeogenesis, signaling-related proteins, SIRT1/FOXO1...
To investigate the relationship of aspartate aminotransferase to alanine ratio (AST/ALT) and metabolic syndrome (MetS) in adolescents northeast China.A stratified cluster random sample 935 students 11-16 years age a city China were enrolled 2010-2011. Participants given physical examination laboratory evaluation, 93 participants followed-up after 5 years.AST/ALT was negatively correlated with waist circumference (WC), waist-to-hip ratio, body mass index (BMI), diastolic blood pressure,...
Objective: At present, the association of body mass index (BMI) with prognosis liver cirrhosis is controversial. Our retrospective study aimed to evaluate impact BMI on outcome cirrhosis. Methods: In first part, long-term death was evaluated in 436 patients and without malignancy from our prospectively established single-center database. second in-hospital 379 acute gastrointestinal bleeding (AGIB) multicenter study. calculated categorized as underweight (BMI &lt;18.5 kg/m 2 ), normal...
Background and Objectives Genitourinary syndrome of menopause (GSM) is a common condition affecting most postmenopausal women, which greatly impacks the quality life,and need to treat. This prospective multicenter cohort study aimed compare efficacy safety fractional carbon dioxide (CO 2 ) laser with that topical estrogen for vaginal treatment relieving symptoms genitourinary (GSM). Study Design/Materials Methods included 162 patients who received or Estriol cream therapy between January...
The levels of tumor markers in pancreatic neuroendocrine carcinoma (PNEC) are unknown, and imaging findings PNEC ductal adenocarcinoma (PDAC) have overlaps. In this study, we show the evaluate their values for distinguishing from PDAC.Thirty-three cases PDAC 21 were retrospectively evaluated. demographic information clinical data reviewed.Pancreatic was usually misdiagnosed (57.1%) as based on findings. Abnormal carbohydrate antigen (CA) 19-9, carcinoembryonic (CEA), α-fetoprotein (AFP)...
Ginsenoside Rf, a tetracyclic triterpenoid only present in Panax ginseng, has been proven to relieve lipid metabolism and inflammatory reactions, which can be potential treatment for nonalcoholic fatty liver disease (NAFLD). Therefore, this study aimed reveal the underlying mechanisms of ginsenoside Rf early-stage NAFLD (NAFL) by using bioinformatics method biological experiments.Target genes associated with NAFL were screened from Gene Expression Omnibus (GEO) database, database repository...