A5052738922- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Liver physiology and pathology
- Spectroscopy Techniques in Biomedical and Chemical Research
- Liver Diseases and Immunity
- Renal Transplantation Outcomes and Treatments
- Diabetes and associated disorders
- HIV/AIDS drug development and treatment
- Ultrasound Imaging and Elastography
- Diabetic Foot Ulcer Assessment and Management
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Diet, Metabolism, and Disease
- Cannabis and Cannabinoid Research
- Orthopedic Infections and Treatments
- Pulmonary Hypertension Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug-Induced Adverse Reactions
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Genetic and Kidney Cyst Diseases
- Immunodeficiency and Autoimmune Disorders
- Celiac Disease Research and Management
Medizinische Hochschule Hannover
2014-2024
Columbia University
2012-2022
German Liver Foundation
2013
King Faisal Specialist Hospital & Research Centre
2011
Klinički centar Vojvodine
2011
Freeman Hospital
2011
Fundação de Medicina Tropical
2010
Amsterdam UMC Location University of Amsterdam
2009
Hôpital Beaujon
2009
The University of Tokyo
2009
Increased translocation of intestinal bacteria is a hallmark chronic liver disease and contributes to hepatic inflammation fibrosis. Here we tested the hypothesis that microbiota Toll-like receptors (TLRs) promote hepatocellular carcinoma (HCC), long-term consequence injury, inflammation, Hepatocarcinogenesis in chronically injured livers depended on TLR4 activation non-bone-marrow-derived resident cells. were not required for HCC initiation but promotion, mediating increased proliferation,...
Although it is well established that hepatic macrophages play a crucial role in the development of liver fibrosis, underlying mechanisms remain largely elusive. Moreover, not known whether other mononuclear phagocytes such as dendritic cells (DCs) contribute to stellate cell (HSC) activation and fibrosis. We show for first time enhance myofibroblast survival nuclear factor kappa B (NF-κB)-dependent manner thereby promote Microarray pathway analysis revealed no induction HSC pathways by but...
Cancer-associated fibroblasts (CAF) may exert tumor-promoting and tumor-suppressive functions, but the mechanisms underlying these opposing effects remain elusive. Here, we sought to understand potentially functions by interrogating functional relationships among CAF subtypes, their mediators, desmoplasia, tumor growth in a wide range of types metastasizing liver, most common organ site for metastasis. Depletion hepatic stellate cells (HSC), which represented main source mice patients our...
In many organs, including the intestine and skin, cancers originate from cells of stem or progenitor compartment. Despite its nomenclature, cellular origin hepatocellular carcinoma (HCC) remains elusive. contrast to most liver lacks a defined cell population for organ maintenance. Previous studies suggest that both hepatocytes facultative within biliary compartment are capable generating HCC. As HCCs with signature carry worse prognosis, understanding HCC is clinical relevance. Here, we used...
Transient elastography is increasingly being used in patients with chronic liver disease. It has proven particularly useful to identify advanced fibrosis or cirrhosis, while classification of no little appears be difficult. In general, stiffness values <6 kPa are considered normal, whereas higher levels candidates for a disease-specific treatment further diagnostic evaluation. Parameters influencing may include food intake that increases blood flow.In pilot study, transient was performed...
Fibrosis contributes to ~45% of deaths in western countries. In chronic liver disease, fibrosis is a major factor determining outcomes, but efficient antifibrotic therapies are lacking. Although platelet-derived growth and transforming factor–β constitute key fibrogenic mediators, they do not account for the well-established link between cell death liver. Here, we hypothesized that damage-associated molecular patterns (DAMPs) may epithelial fibrogenesis injured DAMP receptor screening...
Determination of hepatitis D virus (HDV) viremia represents the "gold standard" for diagnosis HDV infection. Hepatitis B (HBV)-HDV coinfection frequently leads to end-stage liver disease and hepatocellular carcinoma. No commercial assay RNA quantification that includes automated nucleic acid extraction is available, in-house PCR tests are not well standardized. However, knowledge levels may give important information patient management could be a useful tool monitoring response antiviral...
Impairment of renal function often occurs in patients with liver disease. Hepatorenal syndrome is a significant cause acute kidney injury (AKI) cirrhosis (HRS-AKI, type 1). Causes non-HRS-AKI include cholemic nephropathy (CN), disease that characterized by intratubular bile casts and tubular injury. As data on CN are obtained primarily from case reports or autopsy studies, we aimed to investigate the frequency clinical course CN. We identified 149 who underwent biopsy between 2000 2016 at...
Summary Persistence of hepatitis B virus (HBV) infection is associated with reduced anti-viral T cell responses. Impaired dendritic (DC) function was suggested as the cause stimulation in chronic HBV carriers. Thus, we compared myeloid (mDC) and plasmacytoid DC (pDC) from carriers controls. Frequency phenotype isolated were analysed by fluorescence activated sorter staining, mixed lymphocyte reaction, cytokine bead array, intracellular enzyme-linked immunosorbent assay immunospot. Expression...
A considerable proportion of patients receiving liver transplants for Budd-Chiari syndrome (BCS) suffer from myeloproliferative neoplasms (MPN). This study evaluated the long-term prognosis liver-transplanted with BCS secondary to MPN and effect immunosuppression on progression.A total 78 were between 1982 2013. Of those, 40 suffered polycythaemia vera (PV) essential thrombocythaemia (ET). One patient had primary myelofibrosis (PMF). All received standard immunosuppressive regimen. We...
<h3>Objective</h3> The endocannabinoid system (ECS) exerts key roles in the development of liver fibrosis and fatty liver, two diseases that promote hepatocellular carcinoma (HCC). Although cannabinoids exert potent antitumour effects vitro, contribution ECS to carcinogenesis vivo remains elusive. <h3>Design</h3> Expression components ECS, including endocannanabinoids, endocannabinoid-degrading enzymes receptors, was determined healthy tumours. Diethylnitrosamine-induced hepatocarcinogenesis...
Background & Aims: Drug induced liver injury (DILI) is a rare but potentially serious clinical condition. One phenotype of DILI termed drug-induced autoimmune like hepatitis (DI-ALH) that presents with laboratory and histological features indistinguishable from hepatitis. Liver kidney microsomal antibodies (LKM-antibodies) are common in the diagnosis AIH were also described to be associated halothane-induced DILI. Also, antigens anti-LKM-1 anti-LKM-2 belong cytochrome P450 enzyme family...