A5100700241- Heavy Metal Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Water Treatment and Disinfection
- Air Quality and Health Impacts
- Mesenchymal stem cell research
- Immunotoxicology and immune responses
- Mercury impact and mitigation studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Trace Elements in Health
- Heme Oxygenase-1 and Carbon Monoxide
- Plant tissue culture and regeneration
- Birth, Development, and Health
- Immune Response and Inflammation
- Carcinogens and Genotoxicity Assessment
- Electrochemical Analysis and Applications
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- Toxic Organic Pollutants Impact
- Chemical Analysis and Environmental Impact
- Health, Environment, Cognitive Aging
- Paraquat toxicity studies and treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- Autism Spectrum Disorder Research
- Adipokines, Inflammation, and Metabolic Diseases
Children's Hospital of Zhejiang University
2020-2025
Fudan University
2016-2025
Dalian Medical University
2024-2025
Ocean University of China
2022-2025
Lishui University
2021-2024
State Forestry and Grassland Administration
2024
Shanghai Jiao Tong University
2024
Wuhan Center for Disease Control and Prevention
2021-2024
China Pharmaceutical University
2013-2024
China University of Petroleum, East China
2024
BTBR T+tf/J (BTBR) mice have recently been reported to behaviors that resemble those of autistic individuals, in this strain has impairments social interactions and a restricted repetitive stereotyped pattern behaviors. Since immune responses, including autoimmune are known affect behavior, individuals with autism aberrant activities, we evaluated the system mice, compared their immunity degree neuroinflammation C57BL/6 (B6) highly control strain, F1 offspring. Mice were assessed at...
Prenatal exposure to heavy metals, pesticides and phenols has been suggested interfere with neurodevelopment, but the neurotoxicity of their mixtures is still unclear. We aimed elucidate associations maternal urinary concentrations selected chemical intelligence quotient (IQ) in children. Maternal pesticide metabolites, were quantified pregnant women who participated Sheyang Mini Birth Cohort Study (SMBCS) from June 2009 January 2010. At age 7 years, child's IQ score was assessed using...
Bone marrow (BM) resident macrophages (Mϕs) regulate hematopoietic stem cell (HSC) mobilization; however, their impact on HSC function has not been investigated. We demonstrate that depletion of BM Mϕs increases proliferation as well the pool quiescent HSCs. At same time, during bacterial infection where are selectively increased we observe a decrease in numbers. Moreover, strategies deplete or reduce prevent loss and rescue function. previously found transient HSCs is interferon-gamma...
Ascorbate (AsA), an antioxidant that cannot be synthesized or stored by the human body, plays essential role in proper functioning of both plants and humans. With goal increasing AsA level lettuce, effects different ratios red (R) to blue (B) light (75R:25B, 50R:50B, 25R:75B) on pool sizes as well transcript levels activities key enzymes involved metabolism were constantly monitored for 12 days under continuous (200 μmol·m-2·s-1) from LEDs. The results showed lettuce biomass was positively...
In this study, specific dynamic changes in growth, oxidative stress, ascorbate metabolism, and chlorophyll fluorescence were monitored during 12 days lettuce plants exposed to continuous light (CL) of different intensities: low (LL, 100 μmol·m-2·s-1), medium (ML, 200 high (HL, 300 μmol·m-2·s-1). Lettuce grown under CL higher intensity gained greater biomass, dry weight ratio, root/shoot leaf FW, but not area. Both the reactive oxygen species (ROS) production lipid peroxidation degree,...
Fenoxaprop-p-ethyl (FE), a type of acetyl-CoA carboxylase (ACCase) inhibitor, has been extensively applied to variety crop plants. It can cause damage wheat (Triticum aestivum) even resulting in the death crop. On prerequisite not reducing herbicidal efficiency on target weed species, herbicide safeners selectively protect crops from injury. Based fragment splicing, series novel substituted pyrazole derivatives was designed ultimately address phytotoxicity caused by FE. The title compounds...
PGC-1α is an inducible transcriptional coactivator that regulates cellular energy metabolism and adaptation to environmental nutritional stimuli. In tissues expressing PGC-1α, alternative splicing produces a truncated protein (NT-PGC-1α) corresponding the first 267 amino acids of PGC-1α. Brown adipose tissue also expresses two novel exon 1b-derived isoforms NT-PGC-1α, which are 4 13 shorter in N termini than canonical respectively. To evaluate ability NT-PGC-1α substitute for assess...
Background: As a ubiquitous environmental pollutant, methylmercury (MeHg) induces toxic effects in the nervous system, one of its main targets. However, exact mechanisms neurotoxicity have not been fully elucidated. Hypoxia-inducible factor-1α (HIF-1α), transcription factor, plays crucial role adaptive and cytoprotective responses cells is involved cell survival, proliferation, apoptosis, inflammation, angiogenesis, glucose metabolism, erythropoiesis, other physiological activities....
Enhanced gut permeability due to dysregulated epithelial tight junction is often associated with inflammatory bowel diseases (IBD), which have a greater risk for developing colorectal cancer. STAT6 activation was detected in inflamed colonic epithelium of active IBD patients, suggesting role colitis development. Here, we demonstrated that non-hematopoietic STAT6, but not hematopoietic triggered DSS-induced and subsequent tumorigenesis. This could be the enhancing-effect on microbiota...
Adipose tissue macrophages (ATM) are key players in the development of obesity and associated metabolic inflammation which contributes to systemic dysfunction. We here found that fibroblast activation protein α (FAP), a well-known marker cancer-associated fibroblast, is selectively expressed murine human ATM among adipose tissue-infiltrating leukocytes. Macrophage FAP deficiency protects mice against diet-induced proinflammatory macrophage infiltration obese tissues, thereby alleviating...
Abstract Chemical cleaning is one of the key technical means to control membrane fouling, restore flux and ensure stable operation systems. In experiment, six most representative chemical agents for ceramic membranes, such as sulfuric acid (H2SO4), sodium hydroxide (NaOH), hypochlorite (NaClO), ethylenediaminetetraacetic disodium salt (EDTA-Na2), dodecyl sulfate (SDS) nonylphenol polyoxyethylene ether (OP-10), were used research objects. The effect two-step combined on fouled was...