A5060684356- Pesticide and Herbicide Environmental Studies
- Weed Control and Herbicide Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Synthesis and Biological Evaluation
- Allelopathy and phytotoxic interactions
- Microbial Fuel Cells and Bioremediation
- Synthesis and biological activity
- Toxic Organic Pollutants Impact
- Per- and polyfluoroalkyl substances research
- Fungal Plant Pathogen Control
- Soil Carbon and Nitrogen Dynamics
- Photosynthetic Processes and Mechanisms
- Microplastics and Plastic Pollution
- Pesticide Exposure and Toxicity
- Electrospun Nanofibers in Biomedical Applications
- Microbial Community Ecology and Physiology
- Electrokinetic Soil Remediation Techniques
- Click Chemistry and Applications
- Atmospheric chemistry and aerosols
- Neurogenesis and neuroplasticity mechanisms
- HIV Research and Treatment
- Environmental Toxicology and Ecotoxicology
- Glutathione Transferases and Polymorphisms
Northeast Agricultural University
2016-2025
Agro-Environmental Protection Institute
2016-2025
Ministry of Agriculture and Rural Affairs
2019-2025
Molina Center for Energy and the Environment
2020-2023
Inner Mongolia Agricultural University
2022
University of Nebraska Medical Center
2011-2018
Fujian Agriculture and Forestry University
2018
Harbin University
2017-2018
Nanyang Institute of Technology
2017-2018
Nankai University
2012-2017
Glutaminase 1 is the main enzyme responsible for glutamate production in mammalian cells. The roles of macrophage and microglia glutaminases brain injury, infection, inflammation are well documented. However, little known about regulation neuronal glutaminase, despite neurons being a predominant cell type glutaminase expression. Using primary rat human cultures, we confirmed that interleukin-1β (IL-1β) tumor necrosis factor-α (TNF-α), two pro-inflammatory cytokines typically elevated...
Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is an important target for discovering novel herbicides, and it causes bleaching symptoms by inhibiting the synthesis of chlorophyll heme. In this study, active fragments several commercial herbicides were joined substructure splicing bioisosterism, a series diphenyl ether derivatives containing five-membered heterocycles synthesized. The greenhouse herbicidal activity PPO inhibitory in vitro discussed detail. results showed that most compounds...
Bioelectric field is a stimulated force to degrade xenobiotic pollutants in soils. However, the effect of bioelectric on microplastics (MPs) aging unclear. The degradation behavior polyvinyl chloride (PVC), polyethylene (PE) and polylactic acid (PLA) was investigated an agricultural soil microbial electrochemical system which generated in-situ by native microbes. Based density function theory, energy gaps between highest lowest occupied molecular orbitals three polymers with periodic...
Microglia represent the main cellular targets of HIV-1 in brain. Infected and/or activated microglia play a pathogenic role HIV-associated neurocognitive disorders (HAND) by instigating primary dysfunction and subsequent death neurons. Although are known to secrete neurotoxins when infected with HIV-1, detailed mechanism neurotoxicity remains unclear. Using human culture system macrophage-tropic strains, we have now demonstrated that infection resulted significant increase extracellular...
4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is an important target site for discovering new bleaching herbicides. To explore novel HPPD inhibitors with excellent herbicidal activity, a series of N-aroyl diketone/triketone derivatives were rationally designed by splicing active groups and bioisosterism. Bioassays revealed that most these displayed preferable activity against Echinochloa crus-galli (EC) at 0.045 mmol/m2 Abutilon juncea (AJ) 0.090 mmol/m2. In particular, compound...
To seek new protoporphyrinogen oxidase (PPO) inhibitors with better biological activity, a series of novel diphenyl ether derivatives containing tetrahydrophthalimide were designed based on the principle substructure splicing and bioisomerization. PPO inhibition experiments exhibited that 6c is most potential compound, half-maximal inhibitory concentration (IC50) value 0.00667 mg/L, showing 7 times higher activity than Oxyfluorfen (IC50 = 0.0426 mg/L) against maize similar herbicidal...
Herbicide safeners selectively protect crops from herbicide damage without reducing the herbicidal efficiency on target weed species. The title compounds were designed by intermediate derivatization approach and fragment splicing to exploit novel potential safeners. A total of 31 diazabicyclo derivatives synthesized microwave-assistant method using isoxazole-4-carbonyl chloride derivatives. All synthetic confirmed infrared, 1H 13C nuclear magnetic resonance, high-resolution mass...
Abstract BACKGROUND Isoxaflutole (IXF), as a kind of 4‐hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor, has been widely used in many kinds plants. IXF can cause injury corn including leaf and stem bleaching, plant height reduction or stunting, reduced crop stand. Safeners are co‐applied with herbicides to protect crops without compromising weed control efficacy. With the ultimate goal addressing Zea mays caused by IXF, series novel substituted dichloroacetylphenyl sulfonamide derivatives...