Xinfeng Guo

ORCID: 0000-0003-2699-9740
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About
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Research Areas
  • Acupuncture Treatment Research Studies
  • Traditional Chinese Medicine Studies
  • Complementary and Alternative Medicine Studies
  • Respiratory and Cough-Related Research
  • interferon and immune responses
  • Plant-based Medicinal Research
  • Healthcare and Venom Research
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Dermatology and Skin Diseases
  • RNA regulation and disease
  • Pain Management and Placebo Effect
  • Psoriasis: Treatment and Pathogenesis
  • Pharmacological Effects of Natural Compounds
  • Ginkgo biloba and Cashew Applications
  • Chronic Kidney Disease and Diabetes
  • Pediatric health and respiratory diseases
  • Traditional Chinese Medicine Analysis
  • Sleep and related disorders
  • Medical Research and Treatments
  • Ginseng Biological Effects and Applications
  • Systemic Lupus Erythematosus Research
  • Non-Destructive Testing Techniques
  • Migraine and Headache Studies
  • RNA Research and Splicing
  • Clinical practice guidelines implementation

Guangzhou University of Chinese Medicine
2016-2025

University of Pittsburgh
2020-2025

Guangdong Provincial Hospital of Traditional Chinese Medicine
2014-2024

Xi’an University
2022-2024

Xi'an University of Technology
2022-2024

Guangdong Academy of Medical Sciences
2014-2023

East China University of Science and Technology
2019-2023

Institute of Hydrobiology
2023

University of Chinese Academy of Sciences
2014-2023

Guangzhou University
2005-2022

Variants of the RNA-editing enzyme ADAR1 cause Aicardi-Goutières syndrome (AGS), in which severe inflammation occurs brain due to innate immune activation. Here, we analyze status and activation an AGS mouse model that carries Adar P195A mutation N terminus p150 isoform, equivalent P193A human Zα variant causal for disease. This alone can interferon-stimulated gene (ISG) expression brain, especially periventricular areas, reflecting pathologic feature AGS. However, these mice, ISG does not...

10.1016/j.celrep.2023.112733 article EN cc-by-nc-nd Cell Reports 2023-07-01

The overexpression of IRX1 gene correlates with the growth arrest in gastric cancer. Furthermore, suppresses peritoneal spreading and long distance metastasis. To explore precise mechanisms, we investigated whether restoring expression affects angiogenesis or vasculogenic mimicry (VM). Human umbilical vein endothelial cells (HUVECs) chick embryo SGC-7901 cancer were used for VM analysis. Small interfering RNA was analyzing function BDKRB2, a downstream target IRX1. As results, remarkable...

10.1038/onc.2011.154 article EN cc-by-nc-nd Oncogene 2011-05-23

Aicardi-Goutières syndrome (AGS) is a severe infant or juvenile-onset autoimmune disease characterized by inflammatory encephalopathy with an elevated type 1 interferon-stimulated gene (ISG) expression signature in the brain. Mutations seven different protein-coding genes, all linked to DNA/RNA metabolism sensing, have been identified AGS patients, but none of them has demonstrated activate IFN pathway brain animal. The molecular mechanism not well defined. Adenosine Deaminase Acting on RNA...

10.1186/s12974-021-02217-9 article EN cc-by Journal of Neuroinflammation 2021-07-31

Objectives To assess the feasibility and acceptability of a randomized controlled trial compared auricular acupressure (AA) on specific acupoints with AA non-specific for treating maintenance hemodialysis (MHD) patients insomnia. Methods Sixty three (63) eligible subjects were randomly assigned into either group received (n=32), or sham (SAA) points irrelevant to insomnia treatment (n=31) eight weeks. All participants followed up 12 weeks after treatments. The primary outcome was clinical...

10.1371/journal.pone.0122724 article EN cc-by PLoS ONE 2015-04-15
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