A5077469650- Restless Legs Syndrome Research
- Dialysis and Renal Disease Management
- Sleep and Wakefulness Research
- Sleep and related disorders
- Gut microbiota and health
- Acute Kidney Injury Research
- Diet and metabolism studies
- Chronic Kidney Disease and Diabetes
- Dietary Effects on Health
- Therapeutic Uses of Natural Elements
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Circadian rhythm and melatonin
- Functional Brain Connectivity Studies
- Medical Research and Treatments
- Hydrogen's biological and therapeutic effects
- Cardiovascular Effects of Exercise
- Cardiac Fibrosis and Remodeling
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Periodontal Regeneration and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Tea Polyphenols and Effects
- Renal function and acid-base balance
- Hemodynamic Monitoring and Therapy
Guangzhou University of Chinese Medicine
2019-2025
Wuhan University of Science and Technology
2024
Central South University
2011-2024
Central South University of Forestry and Technology
2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2012-2022
Fo Guang Shan
2013
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2011
Objectives To assess the feasibility and acceptability of a randomized controlled trial compared auricular acupressure (AA) on specific acupoints with AA non-specific for treating maintenance hemodialysis (MHD) patients insomnia. Methods Sixty three (63) eligible subjects were randomly assigned into either group received (n=32), or sham (SAA) points irrelevant to insomnia treatment (n=31) eight weeks. All participants followed up 12 weeks after treatments. The primary outcome was clinical...
Objectives: Trimethylamine N-oxide (TMAO), a metabolic product of gut flora, is increased in chronic kidney disease (CKD) subjects and recognized as one type uremic toxins which associated with poor cardiovascular outcomes function loss. Previous studies have suggested that rhubarb enema could reduce circulating such urea, creatinine, indoxyl sulfate also regulate the intestinal microbiota. However, whether retards dysfunction by reducing TMAO its underlying mechanism, are still unclear. The...
Chronic kidney disease (CKD) causes atrial structural remodeling and subsequently increases the incidence of fibrillation (AF). Atrial connexins inflammatory responses may be involved in this process. In study, nephrectomy was used to produce CKD rat model. Three months post-nephrectomy, cardiac structure, function AF vulnerability were quantified using echocardiography electrophysiology methods. The left tissue tested for quantification fibrosis inflammation, distribution expression...
Background: Insomnia is common in patients undergoing maintenance hemodialysis (MHD). Long-term use of sedative-hypnotic agents often correlated with increasing adverse effects. Auricular acupressure therapy (AAT) applied to specific auricular acupoints for managing insomnia has achieved favorable outcomes a unit. This pilot study was performed demonstrate the potential AAT MHD and prepare future randomized controlled trial. Methods: Eligible were enrolled into this descriptive received...
The incidence of CKD seriously endangers people's health. Researchers have proposed that improving the intestinal barrier damage in may be an effective target for delaying progression CKD. Rhubarb can effectively improve and renal fibrosis, which related to regulation gut dysbiosis, but mechanism needs further studied. Short-chain fatty acids (SCFAs) are important metabolites microbiota play role maintaining barrier. purpose this study was investigate whether rhubarb enema regulates...
Objectives: As nitrogen-free precursors of corresponding essential amino, α -ketoacid have been widely prescribed to end-stage renal disease patients together with a low protein diet However, the impact on intestinal microbiota in chronic kidney (CKD) individuals is unknown. The study aims at investigating variation and metabolic profile response treatment an adenine-induced CKD rat model. Design: Rats groups were given solution compound tablets. At end study, blood, feces, colon tissues...
Abstract Background and objective Insomnia is one of the common problems encountered in hemodialysis (HD) population, but mechanisms remain unclear. we aimed to (1) detect spontaneous brain activity pattern HD patients with insomnia (HDWI) by using fractional amplitude low frequency fluctuation (fALFF) method (2) further identify regions showing altered fALFF as neural markers discriminate HDWI from those on without (HDWoI) healthy controls (HCs). Method We compared differences among...
Xerostomia is one of the most common complaints in maintenance hemodialysis (MHD) patients. This problem contributes to excess fluid intake and results poor survival outcome. Based on Traditional Chinese Medicine (TCM) theory literature studies, authors have been practicing auricular acupressure therapy (AAT) help patients with xerostomia. pilot study was conducted demonstrate potential AAT for xerostomia MHD patients.Eligible subjects who agreed participate this were recruited provided 4...
Abstract Background Recommended regular saline flushing presents clinical ineffectiveness for hemodialysis (HD) patients at high risk of bleeding with heparin contraindication. Regional citrate anticoagulation (RCA) has previously been used a Ca 2+ containing dialysate prefiltered in one arm (RCA-one). However, is not always achievable and up to 40% results serious clotting the venous expansion chamber. In this study, we have transferred one-quarter TSC from post filter based on RCA-one,...
Patients on maintenance hemodialysis (MHD) frequently complain of insomnia. Poor sleep quality impairs their life and adversely affects long-term outcome. Previously we applied auricular acupressure therapy (AAT) for MHD patients with insomnia yielded favorable results. AAT probably improves by stimulating the vagus nerve inhibiting sympathetic overactivity. However, efficacy in this population is still lacking. The proposed randomized controlled trial (RCT) will evaluate safety improvement...
This study aimed to develop two predictive nomograms for the assessment of long-term survival status in hemodialysis (HD) patients by examining prognostic factors all-cause mortality and cardiovascular (CVD) event mortality.A total 551 HD with an average age over 60 were included this study. The patients' medical records collected from our hospital randomly allocated cohorts: training cohort (n=385) validation (n=166). We employed multivariate Cox assessments fine-gray proportional hazards...
Chronic kidney disease (CKD) is a global public health problem. Currently, as for advanced CKD populations, medication options limited in angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB), which were partially effective. A Chinese herbal compound, Bupi Yishen formula, has showed renal protective potential experiments retrospective studies. This study will evaluate the efficacy safety of formula (BYF) patients with stage 4. In this double blind, dummy,...
Objective: To investigate whether the 5/6 nephrectomized (5/6Nx) rats’ 12-week serum could lead to tubular epithelial-to-mesenchymal transition (EMT) and its molecular mechanism, so as probe potential stimulation from circulation in chronic progressive kidney disease. Methods: A total of 24 Sprague Dawley (SD) rats were randomly divided into two groups: sham operation group (sham group) 5/6Nx group. Rats killed 12 weeks after surgery obtain serum. Then we detected expression E-cadherin renal...
Background and objectives: The effect of auricular acupressure (AA) for maintenance hemodialysis (MHD) patients with insomnia has been controversial. This study assessed the efficacy safety AA MHD chronic insomnia. Design, setting, participants, measurements: was a multicenter, double-blind (participant assessor), randomized sham-controlled trial. A total 133 subjects were to receive on active points (AA group, n = 64) or sham (SAA) (SAA 69) 8 weeks followed up 12 weeks. provided by assigned...
The prevalence of SD is high in chronic kidney disorder patients who suffering maintenance hemodialysis whereas little known about the neuropathologic mechanism. We investigated ALFF alterations between MHDSD and HCs those meaningful features were used for constructing discriminating model based SVM algorithm to classify patients. found aberrant spontaneous activities DMN, AN, CEN, VIN Additionally, classifier indicated discriminative above regions demonstrated good performance. This will...
Indoxyl sulfate (IS) is a protein-bound typical uremic toxin that accumulates in patients with impaired kidney function. The laboratory methods used to quantify serum concentrations of IS require improvement. We report an optimal, cost-effective alternative the currently used.The as follows: samples were extracted and deproteinized using acetonitrile then further purified dichloromethane. analyzed high-performance liquid chromatography (HPLC) fluorescence detector at flow rate 1.0 mL/min....
Infection-related hospitalization during the peri-dialysis period (PDP) in patients with end-stage renal disease (ESRD) has received less attention. Considering limited data, we explored risk factors this population. Retrospective analysis using data system to examine for infection ESRD PDP between January 2012 and December 2017. Patients were divided into infected group non-infected according history of infection. Binary Logistic Regression Model was used search factors. A total 478...