A5004586593- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Protein Hydrolysis and Bioactive Peptides
- GABA and Rice Research
- Polysaccharides and Plant Cell Walls
- Inflammatory Bowel Disease
- Fungal Biology and Applications
- Natural Antidiabetic Agents Studies
- Natural Products and Biological Research
- GDF15 and Related Biomarkers
- Metabolism, Diabetes, and Cancer
- Alcohol Consumption and Health Effects
- Immune Response and Inflammation
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Diet and metabolism studies
- Nutritional Studies and Diet
- Dietary Effects on Health
- Nosocomial Infections in ICU
- Garlic and Onion Studies
- Amoebic Infections and Treatments
- Lipid metabolism and disorders
Central South University of Forestry and Technology
2021-2025
Central South University
2021-2025
A high fat and cholesterol diet (HFCD) can modulate the gut microbiota, which is closely related with hypercholesterolemia. This study aimed to explore anti-hypercholesterolemia effect of oryzanol, investigate whether function oryzanol associated microbiota metabolites. 16S rRNA ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry were applied for untargeted metabolomics, respectively. The results showed that HFCD significantly upregulated body accumulation...
Inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn's disease, it is a multifactorial of the intestinal mucosa. Oxidative stress damage inflammation are major risk factors for IBD. Vitamin E has powerful antioxidant anti-inflammatory effects. Our previous work other investigations have shown that vitamin positive effect on prevention treatment In this paper, source structure potential mechanism E's role in IBD were summarized, we also analyzed status deficiency patients...
Alcoholic liver disease (ALD) is primarily caused by long-term excessive alcohol consumption. Cyanidin-3-O-glucoside (C3G) a widely occurring natural anthocyanin with multiple biological activities. This study aims to investigate the effects of C3G isolated from black rice on ALD and explore potential mechanism. C57BL/6J mice (male) were fed standard diet (CON) Lieber-DeCarli liquid-fed (Eth) or supplemented 100 mg/kg/d Diet (Eth-C3G), respectively. Our results showed that could effectively...
Hyperlipidemia is intricately associated with the dysregulation of gut microbiota and host metabolomes. This study explored antihyperlipidemic function oryzanol investigated whether affected microbiome its related metabolites. Hamsters were fed a standard diet (Control) high fat cholesterol (HFCD) or without oryzanol, separately. Our results showed that significantly decreased HFCD-induced accumulation, serum total cholesterol, low-density lipoprotein (LDL-c), LDL-c/HDL-c ratio,...
Several publications report that octacosanol (OCT) has different biological functions. This study was designed to evaluate the antifatigue effect and molecular mechanism of (200 mg/(kg day)) in forced exercise-induced fatigue models trained male C57BL/6 mice. Results showed ameliorated mice's autonomic activities, forelimb grip strength, swimming endurance, levels liver glycogen (LG), muscle (MG), blood lactic acid (BLA), lactate dehydrogenase (LDH), superoxide dismutase (SOD), glutathione...
Edible bird's nest is a natural food tonic and thought to be many health benefits. Sialic acid the main bioactive component contributing biological activity of edible nest. This study aimed clarify effect mechanism sialic on ulcerative colitis through dextran sulfate sodium induced model lipopolysaccharide stimulated RAW264.7 cell inflammation. The results revealed that significantly reduced inflammation MAPK phosphorylation in vivo. In vitro, markedly inhibited productions pro-inflammatory...
The incidence of obesity has increased significantly on account the alterations living habits, especially changes in eating habits. In this study, we investigated effect octacosanol lipid lowering and its molecular mechanism. High-fat diet (HFD)-induced mouse model was used study. Thirty C57BL/6J mice were divided into control, HFD, HFD+Oct groups randomly, every group included ten mice. intragastrically administrated 100 mg/kg/day octacosanol. After 10 weeks for treatment, our results...
To evaluate the anti-inflammatory function of mogroside V (MGV) and its molecular mechanism, dextran sulfate sodium (DSS)-induced colitis lipopolysaccharide (LPS)-induced inflammation model were used in study. Results indicated that MGV (100 mg/kg/day) supplementation diet improved health status mice. Western blot results showed inhibited expression pro-inflammatory factors colonic tissues. significantly reduced expressions cytokines LPS-stimulated RAW264.7 cells, also phosphorylation MAPKs....
Alcoholic liver disease (ALD) has become a health issue globally. Laminarin, low molecular weight marine-derived β-glucan, been identified with multiple biological activities. In this study, the ameliorative effect on ALD of laminarin isolated from brown algae was investigated. Phenotypic, pathological alterations and biochemical characteristics indicated that administration (100 mg/kg/day) significantly alleviated injury improved function in alcohol-induced mice. Gene chip results treatment...
Hyperlipidemia is a common clinical disorder of lipid metabolism in modern society and considered to be one the major risk factors leading cardiovascular-related diseases. Germinated brown rice (GBR) typical whole grain food. The lipid-lowering effect GBR has received increasing attention, but its mechanism action not fully understood. gut microbiota been proposed as novel target for treatment hyperlipidemia. aim this study was investigate effects on high-fat diet (HFD)-fed C57BL/6J mice....