A5100751793- Prenatal Screening and Diagnostics
- Genetic Syndromes and Imprinting
- Microstructure and Mechanical Properties of Steels
- Neurogenetic and Muscular Disorders Research
- Genomic variations and chromosomal abnormalities
- Metal Alloys Wear and Properties
- Congenital Anomalies and Fetal Surgery
- Bacteriophages and microbial interactions
- Metallurgy and Material Forming
- Birth, Development, and Health
- Renal and related cancers
- Connective tissue disorders research
- Magnesium Alloys: Properties and Applications
- Flow Measurement and Analysis
- Polymer Nanocomposite Synthesis and Irradiation
- Vascular Malformations and Hemangiomas
- Prosthetics and Rehabilitation Robotics
- Organ and Tissue Transplantation Research
- Adenosine and Purinergic Signaling
- Circadian rhythm and melatonin
- Hereditary Neurological Disorders
- SARS-CoV-2 and COVID-19 Research
- Congenital limb and hand anomalies
- Cardiac Health and Mental Health
- Cardiomyopathy and Myosin Studies
Jiangnan University
2015-2025
China Pharmaceutical University
2024-2025
Wuhan University of Science and Technology
2024
Peking University
2011-2024
Peking University Third Hospital
2018-2024
Beijing Obstetrics and Gynecology Hospital
2018-2024
Ministry of Education of the People's Republic of China
2018-2024
State Key Laboratory of Natural Medicine
2024
Second Affiliated Hospital of Dalian Medical University
2024
Swiss Tropical and Public Health Institute
2023
The effectiveness of vector-control tools is often assessed by experiments as a reduction in mosquito landings using human landing catches (HLCs). However, HLCs alone only quantify single characteristic and therefore do not provide information on the overall impacts intervention product. Using data from recent semi-field study which used time-stratified HLCs, aspiration non-landing mosquitoes, blood feeding, we suggest Bayesian inference approach for fitting such to stochastic model. This...
Abstract The longevity of grafts remains a major challenge in allogeneic transplantation due to immune rejection. Systemic immunosuppression can impair graft function and also cause severe adverse effects. Here, we report local immuno-protective strategy enhance post-transplant persistence allografts using mesenchymal stem cell membrane-derived vesicle (MMV)-crosslinked hydrogel (MMV-Gel). MMVs are engineered upregulate expression Fas ligand (FasL) programmed death 1 (PD-L1). retained within...
The growing population of hand dysfunction patients necessitates advanced rehabilitation technologies. Current robotic solutions face limitations in motion compatibility and systematic design frameworks. This study develops a rigid–soft coupling robot integrating linkage mechanisms with soft components. A machine vision system captures natural grasping trajectories, analyzed through polynomial regression. Hierarchical constraint modeling an improved artificial bee colony algorithm optimize...
Whole-exome sequencing (WES) is widely used to detect genetic mutations that cause Mendelian diseases, and has been successfully applied in combination with preimplantation diagnosis (PGD) avoid the transmission of defects. We investigated 40 nonconsanguineous families unexplained, recurrent fetal malformations (two or more malformed fetuses) from May 2016 December 2018. Using Trio-WES, we identified 32 disease-associated variants (80% positive rate), which were subsequently verified. Known...
Abstract Preimplantation genetic testing (PGT) can minimize the risk of birth defects. However, accuracy and applicability routine PGT is confounded by uneven genome coverage high allele drop‐out rate from existing single‐cell whole amplification methods. Here, a method to diagnose mutations concurrently evaluate embryo competence leveraging abundant mRNA transcript copies present in trophectoderm cells developed. The feasibility confirmed with 19 donated blastocysts. Next, applied 82...
Abstract Background Haplotyping reveals chromosome blocks inherited from parents to in vitro fertilized (IVF) embryos preimplantation genetic diagnosis (PGD), enabling the observation of transmission disease alleles between generations. However, methods haplotyping that are suitable for single cells limited because a whole genome amplification (WGA) process is performed before sequencing or genotyping PGD, and true haplotype profiles need be constructed based on genotypes can contain many...
Abstract The recently developed “quenching and partitioning” heat treatment “quenching‐partitioning‐tempering” are novel processing technologies, which designed for achieving advanced high strength steels (AHSS) with combination of adequate ductility. Containing amount austenite phase is an important characteristic the above steel, partitioning a key step in Q&P or Q‐P‐T process during enriched carbon achieves thermal stability. However, microstructural evolution steel rather...
Preimplantation genetic diagnosis (PGD) of diseases, combined with human leukocyte antigen (HLA) typing (PGD-HLA), is a useful technique to have healthy offspring that are compatible sibling for hematopoietic stem cells transplantation (HSCT) treat their diseases. Here, we report new strategy using single nucleotide polymorphism (SNP) linkage analysis monogenic disease PGD HLA typing, simultaneously obtain the information chromosomal aneuploidy, target mutations and through low-depth next...
Charcot-Marie-Tooth type 1A (CMT1A), the most frequent of disease, is mainly caused by a 1.4-Mb duplication containing PMP22 gene. There no effective treatment other than general supportive care and symptomatic treatment. Preimplantation genetic testing for monogenic defects (PGT-M) an alternative approach obtaining healthy babies.A new technology analysis method based on next-generation sequencing (NGS) was developed to detect mutations directly. Simultaneously, aneuploidy linkage analyses...
Pseudomonas putida KT2442 is an important bacterium for producing various types of polyhydroxyalkanoate polymers. Phospholipids and lipid A in membranes P. play roles stress responses, but detailed structural information these lipids not known. In this study, phospholipids were isolated from KT2442, their structures analyzed using thin layer chromatography, high performance liquid electrospray ionization/mass spectrometry. Major phosphatidylethanolamine (79.9%), phosphatidylglycero1 (12.7%),...