A5087306149- Epigenetics and DNA Methylation
- Prenatal Screening and Diagnostics
- Renal and related cancers
- Cognitive Abilities and Testing
- CRISPR and Genetic Engineering
- Genetic Syndromes and Imprinting
- Cancer Genomics and Diagnostics
Peking University
2023-2024
Peking University Third Hospital
2023-2024
Beijing Obstetrics and Gynecology Hospital
2023-2024
Ministry of Education of the People's Republic of China
2024
Abstract Preimplantation genetic testing (PGT) can minimize the risk of birth defects. However, accuracy and applicability routine PGT is confounded by uneven genome coverage high allele drop‐out rate from existing single‐cell whole amplification methods. Here, a method to diagnose mutations concurrently evaluate embryo competence leveraging abundant mRNA transcript copies present in trophectoderm cells developed. The feasibility confirmed with 19 donated blastocysts. Next, applied 82...
Gametogenesis plays an important role in the reproduction and evolution of species. The transcriptomic epigenetic alterations this process can influence reproductive capacity, fertilization, embryonic development. rapidly increasing single-cell studies have provided valuable multi-omics resources. However, data from different layers sequencing platforms not been uniformed integrated, which greatly limits their use for exploring molecular mechanisms that underlie oogenesis spermatogenesis....
Abstract Gametogenesis plays an important role in the reproduction and evolution of species. The transcriptomic epigenetic alterations this process can influence reproductive capacity, fertilization, embryonic development. rapidly increasing single-cell studies have provided valuable multi-omics resources. However, data from different layers sequencing platforms not been uniformed integrated, which greatly limits their use for exploring molecular mechanisms that underlie oogenesis...