A5024253929- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Reproductive Biology and Fertility
- Autophagy in Disease and Therapy
- Pediatric health and respiratory diseases
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Single-cell and spatial transcriptomics
- Genetic Syndromes and Imprinting
- Viral Infections and Vectors
- Genetics, Aging, and Longevity in Model Organisms
- Rheumatoid Arthritis Research and Therapies
- COVID-19 Impact on Reproduction
- Circular RNAs in diseases
- Ovarian function and disorders
- Cancer, Lipids, and Metabolism
- Viral Infections and Outbreaks Research
- Gene expression and cancer classification
- Endometrial and Cervical Cancer Treatments
- Pain Mechanisms and Treatments
- Heat shock proteins research
Sichuan Agricultural University
2025
Tianjin University of Science and Technology
2024
Peking University
2017-2023
Peking University Third Hospital
2021-2023
Beijing Obstetrics and Gynecology Hospital
2023
Second Hospital of Shanxi Medical University
2023
Shanxi Medical University
2023
Ministry of Education of the People's Republic of China
2023
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2023
Lysophosphatidic acid (LPA) has diverse biological activities implicated in tumor progression, including increasing cell migration, invasion and metastasis. However, the underlying mechanisms for LPA-induced human hepatocellular carcinoma (HCC) migration are poorly understood.We sought to determine promoting effect of LPA on HCC adhesion by transwell matrix assays, respectively. Levels metalloproteinase, MMP-2 MMP- 9 from cells were assayed ELISA p38 mitogenactivated protein kinase (MAPK)...
Endoplasmic reticulum (ER) stress is caused by the disturbance of ER homeostasis and leads to activation unfolded protein response (UPR), which alleviates at an early stage triggers apoptosis if fails over a prolonged timeframe. Here, we report that reticulocalbin 1 (RCN1), member CREC family, transactivated nuclear factor kappa B (NF-κB) during inhibits stress-induced apoptosis. The depletion RCN1 increases UPR drug-induced activating PRKR-like kinase-CCAAT/enhancer-binding...
Tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) plays a critical role in regulating cell survival, growth, proliferation by antagonizing the PI3K-AKT-mTOR pathway. The regulatory mechanism of PTEN protein is still not completely understood. Here, we found that Sirtuin 4 (SIRT4) interacts with regulates its stability. Overexpression SIRT4 cells causes down-regulation PTEN. This regulation independent acetylation ubiquitination. We further degrades through...
The histone transmethylase complex comprising WD repeat domain 77 (WDR77) and protein arginine methyltransferase 5 (PRMT5) catalyzes dimethylation of H4R3 (H4R3me2) drives cancer cell proliferation migration, but its regulation is not fully understood. Here, we report that sirtuin 7 (SIRT7) directly deacetylates WDR77 this deacetylation interferes with the WDR77-PRMT5 interaction suppresses human colon HCT116 cells. Using co-expression in HEK293T cells co-immunoprecipitation assays, observed...
Abstract The spermatogenesis process is complex and delicate, any error in a step may cause arrest even male infertility. According to our previous transcriptomic data, CEP70 highly expressed throughout various stages of human spermatogenesis, especially during the meiosis deformation stages. present sperm tails that it exists centrosomes as revealed by centrosome proteomics. However, specific mechanism this protein still unknown. In study, we found heterozygous site same mutation on through...
Abstract Transcriptomic and epigenetic alterations during early embryo development have been proven to play essential roles in regulating the cell fate. Nowadays, advances single-cell transcriptomics epigenomics profiling techniques provide large volumes of data for understanding molecular regulatory mechanisms embryos facilitate investigation assisted reproductive technology as well preimplantation genetic testing. However, lack integrated collection unified analytic procedures greatly...
Abstract Background Osteoarthritis (OA) is a worldwide musculoskeletal disorder. However, disease-modifying therapies for OA are not available. Here, we aimed to characterize the molecular signatures of and identify novel therapeutic targets strategies improve treatment OA. Methods We collected genome-wide transcriptome data performed on 132 74 normal human cartilage or synovium tissues from 7 independent datasets. Differential gene expression analysis functional enrichment were genes...
Abstract Background Declining oocyte quality in women with advanced age has been a major impediment to assisted reproductive treatments’ (ART) success rate. However, aging is often accompanied by diminished ovarian reserve (DOR). Cumulus cells (CCs) are known play an important role the development and maturation of oocytes, CCs actually reflects oocyte. In this study, were used investigate real reasons for decline older women. Methods Ninety-nine CC samples subdivided into 4 different groups...
Gametogenesis plays an important role in the reproduction and evolution of species. The transcriptomic epigenetic alterations this process can influence reproductive capacity, fertilization, embryonic development. rapidly increasing single-cell studies have provided valuable multi-omics resources. However, data from different layers sequencing platforms not been uniformed integrated, which greatly limits their use for exploring molecular mechanisms that underlie oogenesis spermatogenesis....
Abstract Pneumonia induced by severe acute respiratory coronavirus 2 (SARS-CoV-2) via ACE2 receptor may affect many organ systems like lung, heart and kidney. An autopsy report revealed positive SARS-Cov-2 detection results in ovary, however, the developmental-stage-specific cell-type-specific risk fetal primordial germ cells (PGCs) adult women ovary remained unclear. In this study, we used single-cell RNA-sequencing (scRNA-seq) datasets spanning several developmental stages of including...
Natural menopause is always accompanied by specific signs and symptoms, suggesting physiological changes in this peoriod. However, no systematic study has assessed the at molecular level ovaries during menopausal transition so far. This integrated quantitative proteome acetyl-proteome to comprehensively uncover of ovarian protein protein-acetylation profiles transitional period. The findings would provide novel insights into biology help relieve treat associated further improving women's...
Objectives Hospital staff are expected to report adverse events safety leaders and risk managers. At our institution, via an incident reporting software system, known as “RL.” These “RL reports” kept separate from patient medical records. Within the Anesthesiology Department, we noted low numbers of RL reports relative events. Anesthesiology-related were scattered within therefore difficult find. We hypothesized that compiling these in one location would increase rates allow for deeper...
Abstract Background: Osteoarthritis (OA) is a worldwide musculoskeletal disorder. However, disease-modifying therapies for OA are not available. Here, we aimed to characterize the molecular signatures of and identify novel therapeutic targets strategies improve treatment OA. Methods: We collected genome-wide transcriptome data performed on 161 88 normal human cartilage or synovium tissues from 9 independent datasets. Differential gene expression analysis functional enrichment were genes...
<h3>Background</h3> Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease characterized by autoantibody production and multisystem inflammation. Alpha-adrenoceptor blockers(AAB), angiotensin converting enzyme inhibitors(ACEI), beta-adrenoceptor blockers(BB) calcium channel blockers(CCB) are common antihypertensive drugs. However, data on their relative impact limited. We leveraged genetic variants mimicking AAB, ACEI, CCB BB drugs to investigate effects risk of SLE...
<h3>Background</h3> Osteoarthritis (OA) is the most common degenerative joint disorder worldwide. Accumulating evidence has demonstrated associations of omega-3 and omega-6 PUFAs with disease activity inflammatory mediators OA, polyunsaturated fatty acids (PUFAs) are recognized for their anti-inflammatory properties<sup>[1]</sup>, while FAs that increased in joints OA<sup>[2]</sup>. However, causal links on risk OA remains inconclusive. <h3>Objectives</h3> This study was conducted to...
Background Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease, which characterized by synovitis and extra-articular inflammation, whose pathophysiology involves complex interplay of environmental genetic factors. The patients with RA are at higher risk morbidity mortality from cardiovascular disease. Hypertension has been reported to be the strongest factor for events in several studies [1] . Alpha-adrenoceptor blockers, Angiotensin converting enzyme inhibitors (ACEI),...
Abstract Gametogenesis plays an important role in the reproduction and evolution of species. The transcriptomic epigenetic alterations this process can influence reproductive capacity, fertilization, embryonic development. rapidly increasing single-cell studies have provided valuable multi-omics resources. However, data from different layers sequencing platforms not been uniformed integrated, which greatly limits their use for exploring molecular mechanisms that underlie oogenesis...