A5068429992- Dysphagia Assessment and Management
- Ear Surgery and Otitis Media
- Hearing, Cochlea, Tinnitus, Genetics
- Tracheal and airway disorders
- Voice and Speech Disorders
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Vestibular and auditory disorders
- Sinusitis and nasal conditions
- Hearing Loss and Rehabilitation
- Head and Neck Cancer Studies
- Cleft Lip and Palate Research
- Oral and Maxillofacial Pathology
- Esophageal and GI Pathology
- Nasal Surgery and Airway Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Otolaryngology and Infectious Diseases
- Facial Nerve Paralysis Treatment and Research
- Head and Neck Anomalies
- Airway Management and Intubation Techniques
- Tumors and Oncological Cases
- Streptococcal Infections and Treatments
- Neuroscience of respiration and sleep
- Bone Tumor Diagnosis and Treatments
- Foreign Body Medical Cases
Tohoku University
2016-2025
Tsumura Research Institute (Japan)
2025
The Japanese Society of Gastroenterological Surgery
2024
Tohoku University Hospital
2016-2024
National Research Institute of Fire and Disaster
2023
Tohoku Medical and Pharmaceutical University
2022
Tohoku Institute of Technology
2020
Nara Medical University
2016
Kawagoe Technical High School
2016
Tata Medical Center
2016
There is little information regarding whether the styloid process "inserts" deeply into temporal bone petrosa. We examined involvement of Reichert's cartilage (RC) in petrosa using sagittal or horizontal histological sections heads from 17 near-term fetuses (25-40 weeks). The cranial part RC usually carried two short branches protrusions (T-shaped appearance). One ended adjacent to future tympanic cavity, while another branch near facial nerve canal. Near latter end, a was fused with...
DFN3, an X chromosome-linked nonsyndromic mixed deafness, is caused by mutations in the BRN-4 gene, which encodes a POU transcription factor. Brn-4-deficient mice were created and found to exhibit profound deafness. No gross morphological changes observed conductive ossicles or cochlea, although there was dramatic reduction endocochlear potential. Electron microscopy revealed severe ultrastructural alterations cochlear spiral ligament fibrocytes. The findings suggest that these fibrocytes,...
Abstract Noise-induced hearing loss (NIHL) is one of the most common sensorineural deficits. Recent studies have demonstrated that pathogenesis NIHL closely related to ischemia-reperfusion injury cochlea, which caused by blood flow decrease and free radical production due excessive noise. This suggests protecting cochlea from oxidative stress an effective therapeutic approach for NIHL. NRF2 a transcriptional activator playing essential role in defense mechanism against stress. To clarify...
Hereditary deafness affects about 1 in 2000 children and mutations the GJB2 gene are major cause various ethnic groups. encodes connexin26, a putative channel component cochlear gap junction. However, pathogenesis of hearing loss caused by remains obscure. The generation mouse model to study function connexin26 during has been hampered fact that Gjb2 knockout mice embryonic lethal. To establish viable we generated transgenic expressing mutant with R75W mutation was identified deaf family...
CD44 is a type I transmembrane glycoprotein associated with poor prognosis in various solid tumors. Since plays critical role tumor development by regulating cell adhesion, survival, proliferation and stemness, it has been considered target for therapy. Anti‑CD44 monoclonal antibodies (mAbs) have developed applied to antibody‑drug conjugates chimeric antigen receptor‑T Anti-pan‑CD44 mAbs, C<sub>44</sub>Mab‑5 C<sub>44</sub>Mab‑46, which recognize both standard (CD44s) variant isoforms were...
GM3 synthase (ST3GAL5) is the first biosynthetic enzyme of a- and b-series gangliosides. Patients with deficiency suffer severe neurological disability deafness. Eight children (ages 4.1 ± 2.3 years) homozygous for ST3GAL5 c.694C>T had no detectable (a-series) or GD3 (b-series) in plasma. Their auditory function was characterized by absence middle ear muscle reflexes, distortion product otoacoustic emissions cochlear microphonics, as well abnormal brainstem responses cortical auditory-evoked...
Abstract The musculoskeletal system, which comprises muscles, tendons, and bones, is an efficient tissue complex that coordinates body movement maintains structural stability. process of its construction into a single functional organization unclear. SRY-box containing gene 9 (Sox9) expressed initially in pluripotent cells subsequently ectodermal, endodermal, mesodermal derivatives. This study investigated how Sox9 controls the development each component system. was MTJ, tendon, bone...
Background Pneumonia is a common cause of illness and death the elderly in Japan. Its prevalence escalating globally with aging population. To describe latest trends pneumonia hospitalizations, especially aspiration (AP) cases, we assessed clinical records patients admitted to core acute care hospitals Miyagi prefecture, Methods A retrospective multi-institutional joint research was conducted for hospitalized aged ≥20 years from January 2019 December 2019. Clinical data were collected...
Whole cell voltage clamp and freeze fracture were used to study the electrophysiological ultrastructural correlates of outer hair (OHC) lateral membrane molecular motors. We find that specific voltage-dependent capacitance, which derives from motility-related charge movement, increases as length decreases. This increasing non-linear density predicts a corresponding increase in sensor-motor density. However, while OHC particle increases, quantitative correspondence is absent. Thus, presumed...
Conclusions: Trans-tympanic plugging of the Eustachian tube (ET) with silicone plug (Kobayashi Plug) induced long-term effectiveness for over 80% chronic and severe patulous ET (PET) patients. The New Kobayashi Plug was more effective fewer complication descent to pharyngeal orifice.Objective: To investigate complications trans-tympanic using a PET.Method: performed 252 ears 191 Prototype (115 82 patients in 2001–2007) (137 109 2008–2013) were inserted PET patients.Results: success rate...
Adenoid cystic carcinoma is a rare malignant tumor arising from exocrine glands such as the major and minor salivary of paranasal sinuses or external auditory canal. Although multiple retrospective clinical studies ACC have been reported to date, questions, 1) long-term prognosis beyond 20 years, 2) usefulness suitability for treatment therapeutic interventions, 3) goal aim for, 4) by recurrence sites, are still unclear. To improve understanding management adenoid head neck (ACC), study with...
The usefulness of computed tomography (CT) in the diagnosis fish bone impaction oesophagus was evaluated. Thirty-two patients were examined by plain X-ray followed direct oesophagoscopy for suspected impaction. Among 25 cases which bones actually removed, foreign bodies not clearly demonstrated 14 (56 per cent). Eleven underwent CT prior to oesophagoscopic examination. Fish all patients. also visualized secondarily-induced inflammatory changes neighbouring structures. In order confirm this...
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To investigate the correlation of sitting 3-D computed tomography (CT) scans Eustachian tube (ET) with subjective and objective findings in patients patulous (PET).Retrospective.Tertiary referral center.A retrospective survey medical records Sen-En Hospital identified 40 62 ears PET between September 2014 June 2015.Diagnosis was based on presence three characteristic aural symptoms (autophony voice or breathing sounds, fullness), as well verification synchronous movement tympanic membrane...
Abstract Age-related hearing loss (AHL) is a progressive sensorineural in elderly people. Although no prevention or treatments have been established for AHL, recent studies demonstrated that oxidative stress closely related to pathogenesis of suggesting suppression leads inhibition AHL progression. NRF2 master transcription factor regulates various antioxidant proteins and cytoprotection factors. To examine whether pathway activation prevents we used Keap1 -knockdown ( FA/FA ) mice, which...
The exact profiles of the clinical symptoms related to SARS-CoV-2 Omicron variant (B.1.1.529) remain largely uncertain. Therefore, this study aimed clarify manifestations infection with variant. We enrolled individuals who were tested by quantitative nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) test at a large screening center in city Japan during B.1.1.529 wave between January and May 2022, after contact COVID-19 patients. Swab tests planned be performed...
Background: Bloodstream infections (BSIs), including persistent bacteremia (PB), are a leading source of morbidity and mortality globally. PB has higher rate than non- PB, but the clinical aspects in terms causative pathogens presence clearance not well elucidated. Therefore, this study aimed to describe epidemiological characteristics real-world setting. Methods: We performed retrospective observational survey patients who underwent blood culture between January 2012 December 2021 at Tohoku...