A5068361265- Innovation Policy and R&D
- Advanced Breast Cancer Therapies
- Semiconductor materials and devices
- Protein Kinase Regulation and GTPase Signaling
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Oral and Maxillofacial Pathology
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Ear and Head Tumors
- Cardiomyopathy and Myosin Studies
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Tumors and Oncological Cases
- Cardiac electrophysiology and arrhythmias
- PARP inhibition in cancer therapy
- Advancements in Semiconductor Devices and Circuit Design
- Eicosanoids and Hypertension Pharmacology
- Head and Neck Surgical Oncology
- Synthesis and biological activity
- Polyomavirus and related diseases
- Apelin-related biomedical research
- Bat Biology and Ecology Studies
- MicroRNA in disease regulation
- Chromatin Remodeling and Cancer
Tohoku University
2018-2025
University of California, San Diego
2024-2025
Sendai Shakai Hoken Hospital
2022
Tohoku Institute of Technology
2020
Tohoku University Hospital
2017-2019
Sendai Medical Center
2017
Yamagata City Hospital Saiseikan
2015
Nagoya University
1984-1996
Mie University
1987
Systematically synthesized derivatives of ML-9, 1-(5-chloronaphthalenesu1fonyl)-1H-hexahydro-1,4-diazepine, were found to inhibit both Ca2+-calmodulindependent and -independent smooth muscle myosin light chain kinases with a similar concentration dependence, their inhibitions the competitive type respect ATP.Moreover, ML-9 as well ATP or ADP exhibited an effective protection inactivation kinase by nucleotide affinity label 5'-p-fluorosulfonylbenzoyladenosine, suggesting that binds at near...
Adenoid cystic carcinoma is a rare malignant tumor arising from exocrine glands such as the major and minor salivary of paranasal sinuses or external auditory canal. Although multiple retrospective clinical studies ACC have been reported to date, questions, 1) long-term prognosis beyond 20 years, 2) usefulness suitability for treatment therapeutic interventions, 3) goal aim for, 4) by recurrence sites, are still unclear. To improve understanding management adenoid head neck (ACC), study with...
<p>Combination therapy with INK128 and palbociclib is effective against HNSCC xenograft</p>
<p>CRISPR screening identified cell cycle pathway as synthetic lethal for mTORi in HNSCC</p>
<p>Combination of INK128 and palbociclib showed strong synergism in HNSCC cells vitro</p>
<p>Upregulation of CCNE1 by palbociclib confers resistance to palbociclib, which can be reverted INK128</p>
Pancreatic cancer is characterized by constitutive activation of mitogen-activated protein kinase /extracellular signal-regulated 1/2 (ERK1/2) driven gain-of-function mutations KRAS. Our previous transcriptome sequencing ERK1/2-attenuated cultured pancreatic cells unveiled numerous downstream genes activated ERK1/2 including ETV5. In this study, we explored the mechanism transcriptional regulation ETV5 in human cells. Detailed reporter assays uncovered a core promoter region spanning between...
Long non-coding RNAs (lncRNAs) have emerged as a significant player in various cancers, including pancreatic cancer. However, how lncRNAs are aberrantly expressed cancers is largely unknown. We hypothesized that would be regulated by signaling pathways and contribute to malignant phenotypes of In this study, understand the significance mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), which major aberrant pathway cancer, for expression lncRNAs, we performed...
The relationship between the functions of calmodulin (CaM) and Ca2+-induced smooth muscle contraction was investigated using a newly synthesized CaM antagonist, 3-(2-benzothiazolyl)-4,5-dimethoxy-N-[3-(4- -phenylpiperidinyl)propyl]benzenesulfonamide (HT-74). We noted selectivity HT-74 for CaM, compared to other calcium-binding proteins target enzymes CaM. As had no significant effect on intensity 8-anilino-1-naphthalene-sulfonic acid (ANS) fluorescence in presence Ca2+-CaM complex,...
A newly synthesized compound, N-(2-guanidinoethyl)-5-isoquinolinesulfonamide (HA-1004), was shown to be a potent inhibitor of two cyclic nucleotide-dependent protein kinases, GMP-dependent kinase and AMP-dependent the Ki values were 1.4 2.3 microM, respectively. HA-1004 relaxed rabbit aortic strips contracted by various agonists with similar ED50 values. Phenotolamine, propranolol atropine did not affect this HA-1004-induced relaxation, thereby suggesting that compound does act through these...
Although nasal septal abscesses are uncommon, their cosmetic complications can be severe. Hence, prompt diagnosis and treatment important. Here, we report a case of aseptic abscess in patient with proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA)-positive ulcerative colitis (UC), which phlebitis was observed granulomatosis polyangiitis (GPA) might co-exist. A 27-year-old female suffered from intermittent abdominal pain diarrhea for several years. She visited our hospital...
Effects of KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine), a specific Ca++/calmodulin (CaM)-dependent protein kinase inhibitor, were examined on the rate spontaneous beating and intracellular Ca++ transient cultured myocytes from fetal mouse ventricle. depressed in dose-dependent fashion. Spontaneous ceased 10 min after administration 1 microM recovered gradually washing with medium. Addition KN-04 [N-(1-1[P-(5-isoquinolinsulfonyl)benzyl]-2-(4-...
Abstract The comprehensive genomic analysis of the head and neck squamous cell carcinoma (HNSCC) oncogenome revealed frequent loss p16INK4A (CDKN2A) amplification cyclin D1 genes in most human papillomavirus–negative HNSCC lesions. However, cyclin-dependent kinase 4 6 (CDK4/6) inhibitors have shown modest effects clinic. aberrant activation PI3K/mTOR pathway is highly prevalent HNSCC, recent clinical trials promising efficacy mTOR (mTORi) neoadjuvant adjuvant settings but not patients with...
Salivary gland cancers (SGCs) are heterogeneous tumors, and precision oncology represents a promising therapeutic approach; however, its impact on SGCs remains obscure. This study aimed to establish translational model for testing molecular-targeted therapies by combining patient-derived organoids genomic analyses of SGCs. We enrolled 29 patients, including 24 with 5 benign tumors. Resected tumors were subjected organoid monolayer cultures, as well whole-exome sequencing. Organoid cultures...
Abstract Observations of caravaning were made on the domesticated musk shrew (Suncus murinus) with particular reference to its developmental aspects. In a rearing box (Experiment I), appeared from 10 22 days age, peaking at 16 days. open-field test II), it occurred over range 5 days, peak around 13 Its formation patterns also changed age days; five identified in this situation. Another type (encounter test; Experiment III) showed sensitive period similar that obtained II. Caravaning peaked...