A5035197786- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Renal and related cancers
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Renal Transplantation Outcomes and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Sarcoma Diagnosis and Treatment
- Maternal and fetal healthcare
- Metabolism and Genetic Disorders
- Occupational and environmental lung diseases
- Multiple and Secondary Primary Cancers
- Actinomycetales infections and treatment
- Medical Imaging and Pathology Studies
Teine Keijinkai Hospital
2016-2025
Tohoku University
2018-2025
Sapporo Higashi Tokushukai Hospital
2022-2024
University of Verona
2023-2024
Tokyo Women's Medical University
2024
Japan Pancreatic Disease Research Foundation
2024
Tohoku University Hospital
2023
Surugadai Nihon University Hospital
2019
Hokkaido University
2016-2018
Histopathological diagnosis of pancreatic ductal adenocarcinoma (PDAC) on endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) specimens has become the mainstay preoperative pathological diagnosis. However, EUS-FNB specimens, accurate histopathological evaluation is difficult due to low specimen volume with isolated cancer cells and high contamination blood, inflammatory digestive tract cells. In this study, we performed annotations for training sets by expert pathologists trained...
Abstract Intraductal papillary neoplasm of the bile duct (IPNB) is a grossly visible biliary with morphological variations and occasional invasion. Recently new classification IPNB into type 1 2 was proposed in which IPNBs consist fine neoplastic glands complex branching glands, seldom foci solid‐tubular components. However, clinicopathological molecular characteristics these types are yet to be identified. We aimed uncover IPNBs. Thirty‐six were studied retrospectively. Clinicopathological...
Abstract Pancreatic cystic neoplasms (PCNs) are a heterogeneous group with varying risks of malignancy. To explore the clinical utility liquid biopsy in cyst type classification, we analyzed GNAS/KRAS mutations circulating cell-free DNA (cfDNA) obtained from 57 patients histologically diagnosed PCNs, including 34 intraductal papillary mucinous (IPMNs) and compared mutant allele prevalence variant patterns paired resected specimens using next-generation sequencing. The positive GNAS cfDNA...
Pancreatic cancer is characterized by constitutive activation of mitogen-activated protein kinase /extracellular signal-regulated 1/2 (ERK1/2) driven gain-of-function mutations KRAS. Our previous transcriptome sequencing ERK1/2-attenuated cultured pancreatic cells unveiled numerous downstream genes activated ERK1/2 including ETV5. In this study, we explored the mechanism transcriptional regulation ETV5 in human cells. Detailed reporter assays uncovered a core promoter region spanning between...
A 56-year-old woman with high-grade or invasive intraductal papillary mucinous neoplasm (IPMN) underwent 3 pancreatic surgeries for initial and recurrent IPMN lesions. Immunostaining genetic analyses of all lesions revealed a consistent mutation in KRAS loss STK11, indicating the same origin these possibility dissemination. Other immunostaining findings, such as MUC expression high Ki-67 labeling index, were among supported their malignant potential. IPMNs STK11 may benefit from tailored...
Metachronous development of intraductal papillary mucinous neoplasms in the remnant pancreas following resection is a significant clinical burden. Our aim was to characterize clinicopathological and molecular features patients with metachronous tumor identify predictive factors possible route(s) dissemination. Seventy-four who underwent no invasive compartment or associated carcinoma were retrospectively analyzed. In development, targeted sequencing 18 genes pancreatic tumorigenesis...
Abstract Information regarding the molecular features of pulmonary pleomorphic carcinoma (PPC) is insufficient. Here, we performed next-generation sequencing to determine genomic and transcriptomic profiles PPC. We sequenced DNAs RNAs 78 specimens from 52 patients with analyzed 15 PPC cases identify intratumoral differences in gene alterations, tumor mutation burden (TMB), RNA expression, PD-L1 expression between epithelial sarcomatoid components. The alterations six primary tumors...
Objective: We aimed to elucidate the clinicopathobiological significance of Serine/Threonine Kinase 11 (STK11) in pancreatic intraductal papillary mucinous neoplasms (IPMNs). Background: STK11 is a tumor suppressor involved certain IPMNs; however, its not well known. Methods: In 184 IPMNs without Peutz-Jeghers syndrome, we analyzed expression and phosphorylated-AMPKa all cases, p16, p53, SMAD4, β-catenin 140 cases by immunohistochemistry; mutations 37 genes, including whole coding exons...
Abstract The molecular mechanisms underpinning the development of metachronous tumors in remnant bile duct following surgical resection primary biliary tract carcinomas (BTCs) are unknown. This study aimed to elucidate these by evaluating clinicopathologic features BTCs, alterations 31 BTC‐related genes on targeted sequencing, and aberrant expression p53, p16, SMAD4, ARID1A β‐catenin immunohistochemistry. Twelve consecutive patients who underwent BTCs BTC with negative margins were enrolled....
Background Despite advances in the diagnosis of pancreatic ductal adenocarcinoma (PDA), histological evaluation small and poorly defined masses pancreas is uncomfortable unsafe. Methods We herein report a case early stage PDA, which multiple KRAS mutations were detected juice preoperatively. A hypoechoic area adjacent to portal vein was through endoscopic ultrasound body. evaluated using plasma, by digital PCR. Results Pancreatic duct biopsy cytology performed with no evidence malignancy;...
Abstract Background and study aims Needle tract seeding during endoscopic ultrasound fine-needle biopsy (EUS-FNB) remains a concern. We investigated whether such occurred in patient with pancreatic ductal adenocarcinoma (PDA). Patient methods Surgically resected EUS-FNB-derived specimens were genotyped to determine if gastric wall tumor that emerged 3 years after curative resection of an early-stage PDA was clonally related the original tumor. Results The histologically resembled primary...
Objective The aim of the study was to clarify diagnostic impact measuring serum anti-p53 antibody (S-p53Ab) in predicting histological grades intraductal papillary mucinous neoplasms (IPMNs) pancreas. Methods We compared measured values and positive prevalence S-p53Ab across different 111 resected IPMN cases. also evaluated TP53 alterations using immunohistochemistry next-generation sequencing. Results Serum were detected 6 cases, all their high-grade dysplasia (HGD) invasive carcinoma...
Objectives This study aimed to establish a reliable and reproducible categorized diagnostic classification system with identification of key features achieve accurate pathological diagnosis endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNAB) samples pancreatic lesions. Methods Twelve pathologists examined virtual whole-slide images EUS-FNAB obtained from 80 patients according proposed categories for diagnosis. Fleiss κ was used assess the concordance. Results A hierarchical...
Abstract Objectives Treating pancreatic ductal adenocarcinoma (PDAC) is a major clinical challenge, owing to its poor prognosis. Understanding the underlying molecular interactions may be crucial in determining PDAC intractability. We elucidated combinatory role of SMAD family member 4 (SMAD4) and Runt-related transcription factor 3 (RUNX3) PDAC. Methods Formalin-fixed paraffin-embedded tissues were obtained from 101 patients who underwent surgical resection SMAD4 RUNX3 expression was...
Pancreatic metastasis from colorectal cancer is rare, and there have been only a few reports of its preoperative diagnosis by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) with immunohistochemical staining. We herein describe the case 77-year-old woman in whom solitary mass pancreatic tail was detected 11 years after rectal resection. The patient also had history pulmonary tumor performed EUS-FNA histopathological examination showed adenocarcinoma CD20+, CD7-, CDX2+ (similar...