A5021491574- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Pediatric Hepatobiliary Diseases and Treatments
- Renin-Angiotensin System Studies
- Cancer Immunotherapy and Biomarkers
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Hormonal Regulation and Hypertension
- Cardiac electrophysiology and arrhythmias
- Nutrition and Health in Aging
- Ferroptosis and cancer prognosis
- Liver Disease and Transplantation
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal and GI Pathology
- Angiogenesis and VEGF in Cancer
- Apelin-related biomedical research
- Cancer Mechanisms and Therapy
Tohoku University
2016-2025
Massachusetts General Hospital
2018-2024
Harvard University
2018-2024
Shizuoka Cancer Center
2018
The Japanese Society of Gastroenterological Surgery
2017
Red Cross Hospital
2007
Showa University
1999-2003
Toyama Prefectural Central Hospital
1996-2002
GTx (United States)
2000
Saitama International Medical Center
1992-1998
Background and Aims Activation of the antitumor immune response using programmed death receptor‐1 (PD‐1) blockade showed benefit only in a fraction patients with hepatocellular carcinoma (HCC). Combining PD‐1 antiangiogenesis has shown promise substantially increasing HCC who respond to treatment, but mechanism this interaction is unknown. Approach Results We recapitulated these clinical outcomes orthotopic—grafted or induced—murine models HCC. Specific vascular endothelial receptor 2...
Background The morbidity rate after pancreaticoduodenectomy remains high. objectives of this retrospective cohort study were to clarify the risk factors associated with serious (Clavien–Dindo classification grades IV–V), and create complication calculators using Japanese National Clinical Database. Methods Between 2011 2012, data from 17,564 patients who underwent at 1,311 institutions in Japan recorded database. analyzed. Results overall rates 41.6% 4.5%, respectively. A pancreatic fistula...
Background and purpose Combining inhibitors of vascular endothelial growth factor the programmed cell death protein 1 (PD1) pathway has shown efficacy in multiple cancers, but disease-specific agent-specific mechanisms benefit remain unclear. We examined defined when combining regorafenib (a multikinase antivascular receptor inhibitor) with PD1 blockade murine hepatocellular carcinoma (HCC) models. Basic procedures used orthotopic models HCC mice liver damage to test effects...
Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC). Mismatch repair-proficient (pMMR) CRCs make up about 95% metastatic CRCs, and are unresponsive to immune checkpoint blockade (ICB) therapy. Here we show that mouse models orthotopic pMMR CRC liver accurately recapitulate the inefficacy ICB therapy in patients, whereas same tumors sensitive when grown subcutaneously. To reveal local, nonmalignant components determine sensitivity treatment, compared...
Carbohydrate antigen (CA) 19–9 levels after resection are considered to predict prognosis; however, the significance of decreased CA19–9 neoadjuvant therapy has not been clarified. This study aimed define prognostic in patients with pancreatic adenocarcinoma. Between 2001 and 2012, 240 consecutive received subsequent at seven high-volume institutions Japan. These were divided into three groups: Normal group (no elevation [≤37 U/ml] before therapy), Responder (elevated [> 37 but afterwards),...
Objective Intrahepatic cholangiocarcinoma (ICC)—a rare liver malignancy with limited therapeutic options—is characterised by aggressive progression, desmoplasia and vascular abnormalities. The aim of this study was to determine the role placental growth factor (PlGF) in ICC progression. Design We evaluated expression PlGF specimens from patients assessed effect genetic or pharmacologic inhibition orthotopically grafted mouse models. impact stimulation blockade cells cancer-associated...
Abstract Intrahepatic cholangiocarcinoma (ICC) has limited therapeutic options and a dismal prognosis. Adding blockade of the anti–programmed cell death protein (PD)-1 pathway to gemcitabine/cisplatin chemotherapy recently shown efficacy in biliary tract cancers but with low response rates. Here, we studied effects anti–cytotoxic T lymphocyte antigen (CTLA)-4 when combined anti–PD-1 orthotopic murine models ICC. This combination therapy led substantial survival benefits reduction morbidity...
The appearance of cough in association with angiotensin-converting enzyme (ACE) inhibitors is thought to be related bradykinin, and it has been speculated that the elicitation adverse effects genetically predetermined. Several polymorphisms human bradykinin B(2) receptor gene may involved ACE inhibitor-related cough. To investigate this possibility, we identified -58 thymine (T)/cytosine (C) polymorphism subjects We classified study population into 4 groups: without were treated (n=30/30),...
Pancreatico-enterostomy stenosis is a late postoperative complication following pancreaticoduodenectomy. We report case in which surgical "rendezvous" procedure was performed to address the stenosis. A 20-year-old woman underwent laparoscopic pancreaticoduodenectomy for solid pseudopapillary neoplasm pancreatic head. During follow-up, she presented with recurrent abdominal pain, elevated enzymes, and dilation of main duct, suggestive remnant pancreatitis secondary pancreaticojejunostomy...
A single nucleotide polymorphism of mitochondrial 5178A/C, causing a Met to Leu replacement within the NADH dehydrogenase subunit, is reported be associated with longevity. The purpose present study was assess contribution polymorphisms, particularly 5178A/C genotype, susceptibility acute myocardial infarction (AMI) in Japanese population. There were 4 groups: 150 patients AMI, essential hypertension, 100 diabetes mellitus, and subjects matched for age sex who served as control group....
Little is known about the roles of Notch signaling in cholangiocarcinoma (CC). The expression hairy and enhancer split 1 (Hes-1) has not been investigated yet resected specimens CC. reported to be related cancer stem cell (CSC) like properties some malignancies. Our aim investigate participation extrahepatic CC (EHCC) evaluate efficacy cells with CSC-like by blockade. First, Notch1, 2, 3, 4 Hes-1 was examined immunohistochemistry 132 EHCC specimens. clinicopathological characteristics...
<b><i>Aims:</i></b> To investigate whether preoperative enteral diets enriched in eicosapentaenoic acid (EPA) supplements could reduce the incidence of hypercytokinemia after pancreatoduodenectomy (PD) a double-blinded randomized controlled trial. <b><i>Methods:</i></b> Patients with resectable periampullary cancer were into either control group or treatment group. received oral supplementation (600 kcal/day) containing EPA for 7 days before...
Abstract Background Hemihepatectomy with extrahepatic bile duct resection is considered the only curative treatment for perihilar cholangiocarcinoma. The aim of study was to clarify survival benefits in this invasive surgical procedure elderly patients. Methods A total 290 patients who underwent cholangiocarcinoma our department from 2000 2020 were categorized into E group (62 aged ≥75 years) and NE (228 <74 years). Results exhibited decreased pathological lymph node metastasis ( p =...
Objectives: In patients with pancreatic ductal adenocarcinoma (PDAC) and portal vein/superior mesenteric vein (PV/SMV) contact, we can often separate the tumor from PV/SMV avoid resection (VR) owing to favorable efficacy of neoadjuvant therapy (NAT). However, there is a risk that cells may remain around PV/SMV. This study aimed elucidate whether separating justified in NAT setting. Methods: We reviewed PDAC who underwent pancreaticoduodenectomies or total pancreatectomies between 2005 2019....
Abstract Background The prognostic values of inflammation-based markers in well-differentiated pancreatic neuroendocrine neoplasms, diagnosed according to the new 2017 World Health Organization classification, have remained unclear. Therefore, we assessed ability predict recurrence such after curative resection patients with these neoplasms. Methods Circulating/systemic neutrophil–lymphocyte, monocyte–lymphocyte, platelet–lymphocyte, and platelet–white cell ratios were evaluated 120 who...
Expression of the gene for collagen XVII (COL17A1) in tumor tissue is positively or negatively associated with patient survival depending on cancer type. High COL17A1 expression thus a favorable prognostic marker breast but unfavorable pancreatic cancer. This study explored effects growth and their underlying mechanisms. Analysis published single-cell RNA-sequencing data human revealed that was expressed predominantly cells rather than surrounding stromal cells. Forced did not substantially...
Abstract. Nishio K, Mukae S, Aoki Itoh Konno N, Ozawa Satoh R, Katagiri T (School of Medicine Showa University, Hatanodai, Shinagawa‐ku, Tokyo, Japan). Congestive heart failure is associated with the rate bone loss. J Intern Med 2003; 253: 439–446. Aims. To characterize relationships between mineral homeostasis, turnover, mass, and congestive (CHF), we evaluated 75 women mild to moderate CHF. Methods results. We examined association in annual change spinal density (BMD) polymorphism vitamin...