A5074922944- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Ultrasound and Hyperthermia Applications
- Effects of Radiation Exposure
- Cancer Research and Treatments
- Infrared Thermography in Medicine
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Prostate Cancer Treatment and Research
- Medicinal Plants and Bioactive Compounds
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Eicosanoids and Hypertension Pharmacology
- Colorectal Cancer Surgical Treatments
- Pharmacological Effects of Natural Compounds
- Advanced MRI Techniques and Applications
- Neuroblastoma Research and Treatments
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Cancer Cells and Metastasis
- Chemical Reactions and Isotopes
- Metabolomics and Mass Spectrometry Studies
- Virus-based gene therapy research
- Chemokine receptors and signaling
- Colorectal Cancer Treatments and Studies
Massachusetts General Hospital
2010-2024
Harvard University
2008-2024
Sechenov University
2018-2024
NYU Langone Health
2015
Dana-Farber Cancer Institute
2015
Centenary Institute
2015
The University of Sydney
2015
MGH Institute of Health Professions
2007
University Hospital of Lausanne
2005
Harvard University Press
2004
Abstract Elevated interstitial fluid pressure, a hallmark of solid tumors, can compromise the delivery therapeutics to tumors. Here we show that blocking vascular endothelial growth factor (VEGF) signaling by DC101 (a VEGF-receptor-2 antibody) decreases not restoring lymphatic function, but producing morphologically and functionally “normalized” network. We demonstrate normalization process prunes immature vessels improves integrity function remaining vasculature enhancing perivascular cell...
Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes solid stress, with hyaluronan implicated as the primary molecule responsible for vessel compression because of its swelling behaviour. Here we show, unexpectedly, that compresses vessels only in collagen-rich tumours, suggesting collagen together are critical targets decompressing vessels. We demonstrate...
Abstract The extracellular pH of tumor tissue is significantly lower than the normal tissue, whereas intracellular both tissues similar. In principle, acidity may be expected to enhance uptake and cytotoxicity weak acid chemotherapeutics that are membrane permeable in their uncharged state inhibit efficacy bases. However, procedures for assessing role gradient as a determinant drug vivo by altering also alter availability thus mask or exaggerate effect change. present study, we have altered...
Abstract Tumor neovascularization and growth might be promoted by the recruitment of bone marrow–derived cells (BMDC), which include endothelial precursor “vascular modulatory” myelomonocytic (CD11b+) cells. BMDCs may also drive tumor regrowth after certain chemotherapeutic vascular disruption treatments. In this study, we evaluated role BMDC in breast lung carcinoma xenograft models local irradiation (LI). We depleted marrow including whole-body (WBI) 6 Gy as part a total dose 21 Gy,...
Background:Matrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects.
The accumulation and toxicity of the weak base doxorubicin has been investigated as a function extracellular pH, intracellular pH cellular gradient in cells previously cultured under normal (pH 7.4) low-pH (6.8) conditions. Low-pH-adapted exhibit transmembrane gradients which substantially differ from at same pH. No relationship was obtained between uptake or two cell types. In contrast, increased with increasing both low-pH-adapted cells. However, drug cytotoxicity more pronounced than...
Abstract The effects of antiangiogenic therapy on tumors relapsing after irradiation are not known. To this end, we irradiated human growing s.c. in nude mice with a single dose 20 or 30 Gy. Compared primary (treatment-naive) xenografts, the growth rate recurrent was 1.6-fold slower, which is consistent known “tumor bed effect.” For similar size tumors, recurrences had fewer functional vessels, reduced vessel coverage by perivascular cells, and were more necrotic. Placenta factor...
Radiotherapy (RT) is a standard treatment for patients with advanced prostate cancer (PCa). Previous preclinical studies showed that SDF1α/CXCR4 axis could mediate PCa metastasis (most often to the bones) and resistance RT. We found high levels of expression both SDF1α its receptor CXCR4 in primary metastatic tissue samples. In vitro analyses using cells revealed an important role cell invasion but not radiotolerance. Pharmacologic inhibition AMD3100 no efficacy orthotopic bone models....
// Sergey V. Kozin 1,* , Nir Maimon Rong Wang Nisha Gupta 1 Lance Munn Rakesh K. Jain and Igor Garkavtsev Department of Radiation Oncology, Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA * These authors have contributed equally to this paper Correspondence to: Garkavtsev, email: Keywords : SLPI; triple-negative breast cancer; FoxM1; anti-metastatic compound Received September 15, 2017 Accepted October 30, Published November 26, Abstract SLPI has...