A5074471508- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Cervical Cancer and HPV Research
- Sleep and Wakefulness Research
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Nasal Surgery and Airway Studies
- Cardiovascular and Diving-Related Complications
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Sinusitis and nasal conditions
- Antifungal resistance and susceptibility
- Liver Disease Diagnosis and Treatment
- Hearing Loss and Rehabilitation
- Connexins and lens biology
- Graphene research and applications
- Genetic Neurodegenerative Diseases
- Analytical Chemistry and Sensors
- Voice and Speech Disorders
- Respiratory Support and Mechanisms
- Fungal Infections and Studies
- Botulinum Toxin and Related Neurological Disorders
- Gastrointestinal disorders and treatments
Teikyo University Chiba Medical Center
2015-2024
Chiba-Nishi General Hospital
2021
Panasonic (Japan)
1989-2020
Teikyo University
2004-2019
Sleep Comprehensive Care Clinic Yoyogi
2008-2019
Institute of Magnetism
2018
Kagoshima City Hospital
2013
Marymount University
2009
SleepMed
2008
Gifu University
2007
DFN3, an X chromosome-linked nonsyndromic mixed deafness, is caused by mutations in the BRN-4 gene, which encodes a POU transcription factor. Brn-4-deficient mice were created and found to exhibit profound deafness. No gross morphological changes observed conductive ossicles or cochlea, although there was dramatic reduction endocochlear potential. Electron microscopy revealed severe ultrastructural alterations cochlear spiral ligament fibrocytes. The findings suggest that these fibrocytes,...
Hearing loss is the most widespread sensory disorder, with an incidence of congenital genetic deafness 1 in 1600 children. For many ethnic populations, prevalent form caused by recessive mutations gene gap junction protein, beta 2, 26 kDa (GJB2), which also known as connexin (Cx26). Despite this knowledge, existing treatment strategies do not completely recover speech perception. Here we used a delivery system to rescue hearing mouse model Gjb2 deletion. Mice lacking Cx26 are characterized...
Hereditary deafness affects about 1 in 2000 children and mutations the GJB2 gene are major cause various ethnic groups. encodes connexin26, a putative channel component cochlear gap junction. However, pathogenesis of hearing loss caused by remains obscure. The generation mouse model to study function connexin26 during has been hampered fact that Gjb2 knockout mice embryonic lethal. To establish viable we generated transgenic expressing mutant with R75W mutation was identified deaf family...
It is generally considered that patients with obstructive sleep apnea syndrome (OSAS) at increased perioperative risk should be placed in nonsupine positions throughout the recovery process; however, not all OSAS show positional dependence. The authors hypothesized morphological differences exist three-dimensional (3D) soft tissue and craniofacial structures of pharyngeal airway between nonpositional OSAS.The subjects study were body mass index-matched, age-matched, hypopnea index-matched (n...
The purpose of this study was to investigate the effect breathing route on collapsibility pharyngeal airway in patients with obstructive sleep apnea by using computational fluid dynamics technology.This examined Japanese men apnea. Computed tomography scans nose and pharynx were taken during nasal closed mouth, open oral while they awake. Three-dimensional reconstructed stereolithography models digital unstructured grid created airflow simulations performed software.Airflow velocity...
Patients with obstructive sleep apnea syndrome (OSAS) have characteristic dentofacial features, but the sites of obstruction differ greatly. The purpose this study was to investigate characteristics patients OSAS respect sites. subjects consisted 30 Japanese men divided into 3 groups 10 each. One group had at retropalatal and retroglossal region (Rp + Rg group), a second third due tonsillar hypertrophy (tonsillar group). To identify Rp groups, dynamic magnetic resonance imaging (MRI) used....
Study Objectives:To evaluate the morphological features of mandible and volume upper airway soft tissues in determining anatomical risk factors for Japanese male patients with obstructive sleep apnea hypopnea syndrome (OSAHS).
Modified vidian neurectomy combined with inferior turbinoplasty provided an optimal surgical outcome as a treatment for intractable chronic rhinitis evidenced by relatively long-term follow-up.The study was designed to determine the efficacy of submucosal reduction turbinate and resection posterior nasal nerve resistant rhinitis.Fifty-six consecutive patients (37 males 19 females; mean+/-SD age, 26+/-11 years) allergic or nonallergic eosinophilia syndrome despite medical treatment....
Sleep apnea syndrome (SAS) is basically divided into two types: obstructive and central SAS. Recently, the concept of complex SAS has been advocated. Complex defined as that initially manifests primarily SAS, but characterized by frequent apneas after removal upper airway obstruction. To determine prevalence clinical significance among Japanese patients with 1,312 were enrolled in this study. Diagnosis was made based on diagnostic polysomnography, differentiation from polysomnographic...
Nasal obstruction is a common problem in continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea and limits treatment compliance. The purpose of this study to model the effects nasal on airflow parameters under CPAP using computational fluid dynamics (CFD), clarify quantitatively relation between velocity loss coefficient subjects with without obstruction.We conducted an observational cross-sectional 16 Japanese adult subjects, whom 9 had 7 did not (control group)....
Abstract Objective Apoptotic changes have been reported in the aged gerbil cochlea and are speculated to be one of principal causes presbyacusis. The objective study was determine underlying mechanism apoptotic change cochlea. Study Design Prospective controlled animal study. Methods We examined tissue distribution bcl‐2, bax , caspase‐3p20, caspase‐3p32 using immunohistochemical techniques young cochlea, together with measurement distortion product otoacoustic emission (DPOAE). Results Aged...
The focus of this symposium was to present new information on the morphogenesis Candida albicans, particularly how it relates signal transduction pathways and other genes involved in regulation morphogenesis. In addition, we discuss role adherence colonization oral cavity by organism mannan as an adhesin that recognizes human red blood cell. C. albicans utilizes at least two regulate its conversion from a yeast form filamentous growth (hyphae). One these is similar Saccharomyces cerevisiae...
The criteria have not yet been established for identifying the configuration of a pure tone audiogram constituting abnormal results that warrant further investigation. purpose this study was to determine prevalence acoustic neuroma associated with each in patients asymmetric sensorineural hearing loss (SNHL).We performed retrospective chart review 500 15 years age or older who had SNHL and undergone magnetic resonance imaging.The these 2.6% (13 500). audiometric as follows: 7.1% (3 42)...
Hybridomas obtained by fusing the spleen cells of BALB/c female mice hyperimmunized with heat-killed yeast-form Candida albicans NIH B-792 strain and a mouse myeloma cell line, P3X63Ag8.653, produced antibodies to beta-1,2-linked oligomannosyl residues in phosphomannan-protein complex parent cells. Most these monoclonal were IgM, but about 10% hybridomas IgG1 immunoglobulins. Ascites fluid from inoculated an IgG1-producing hybridoma showed different precipitability complexes three...
The critical behaviour of the susceptibility Ising model with a transverse field is investigated by means perturbation expansions. Exact expressions for coefficients up to seventh order in J / k T are given as functions Δ/ quadratic, triangular, simple cubic, b.c.c. and f.c.c. lattices. universality index concluded from analysis temperature obtained function five kinds
Sleep breathing patterns are altered by nasal obstruction and respiratory events. This study aimed to describe the relationships between specific sleep oral flow (OF) patterns, airway obstruction, events.Nasal OF were measured simultaneously polysomnography in 85 adults during sleep. was 2 cm front of lips using a pressure sensor.OF could be classified into three patterns: postrespiratory event (postevent OF), during-respiratory (during-event spontaneous arousal-related (SpAr-related OF)....