A5020946508- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Vibrio bacteria research studies
- Escherichia coli research studies
- Tuberculosis Research and Epidemiology
- Infective Endocarditis Diagnosis and Management
- Cell Image Analysis Techniques
- Tracheal and airway disorders
- Long-Term Effects of COVID-19
- Mast cells and histamine
- Bacillus and Francisella bacterial research
- Lung Cancer Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Listeria monocytogenes in Food Safety
- Dermatological and COVID-19 studies
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Bacterial biofilms and quorum sensing
Tohoku University
2015-2024
Tohoku University Hospital
2021-2024
Shinshu University
2024
National Institute of Infectious Diseases
2020
Fukushima Medical University
2004-2015
In Japan, the clinical characteristics and recent serotype distribution among adult patients of invasive pneumococcal disease (IPD) have not been fully investigated since introduction conjugate vaccine (PCV) in children. From November 2010, PCV7 was encouraged by an official program, funded government, subsequently included routine schedule April 2013, replaced with a PCV13 2013. Between 2013 March 2015, IPD older than 15 years were evaluated based on enhanced national surveillance ten...
Abstract We assessed the impact of pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on meningitis in adults Japan 2014–2018 by comparing epidemiological characteristics with invasive disease (n = 222) and without 1258) meningitis. The annual incidence 2016–2018 was 0.20–0.26 cases/100,000 population . Age (p < 0.001) case fatality rate 0.003) were significantly lower patients than those odds developing higher asplenic/hyposplenic or splenectomized (adjusted ratio [aOR] 2.29, 95%...
Background: Bloodstream infections (BSIs), including persistent bacteremia (PB), are a leading source of morbidity and mortality globally. PB has higher rate than non- PB, but the clinical aspects in terms causative pathogens presence clearance not well elucidated. Therefore, this study aimed to describe epidemiological characteristics real-world setting. Methods: We performed retrospective observational survey patients who underwent blood culture between January 2012 December 2021 at Tohoku...
The decline in the proportion of pneumococcal conjugate vaccine (PCV)-covered serotypes among adult invasive disease (IPD) patients might change overall effectiveness 23-valent polysaccharide (PPSV23) because its differs according to serotype. Using indirect cohort method, we calculated PPSV23 against IPD adults Japan assess impact national pediatric PCV program. Clinical and epidemiologic information isolates were collected from >20 years age through enhanced surveillance during April...
Enhanced surveillance of invasive pneumococcal disease (IPD) in adults was conducted during April 2013–March 2018 10 47 prefectures Japan, and a total 1277 IPD patients were enrolled. An emergence caused by serotype 12F identified May 2015–March through this surveillance. isolates composed four related sequence types. In total, 120 with reported period. To characterize the clinical features IPD, characteristics these compared those 1157 non-12F IPD. Compared patients, significantly lower...
Pneumococcal surface protein A (PspA) is a of Streptococcus pneumoniae that may be candidate antigen for new pneumococcal vaccines. This study investigates the distribution PspA clades causative strains adult invasive disease (IPD) in Japan. Of 1,939 isolated from cases IPD during 2014–2019, 1,932 (99.6%) were determined, and no pspA was detected remaining 7 (0.4%). 1–6 786 (40.5%), 291 (15.0%), 443 (22.8%), 369 (19.0%), 33 (1.7%), 6 (0.3%) strains, respectively. New (0.2%) identified two...
Idiopathic pulmonary fibrosis (IPF), a chronic progressive lung disease of unknown etiology, is characterized by the expansion myofibroblasts and abnormal deposition extracellular matrix in parenchyma. To elucidate molecular mechanisms that lead to IPF, we analyzed established from patients with IPF oligonucleotide microarrays. Gene expression profiles clearly suggested lipid peroxidation enhanced myofibroblasts, which was confirmed measuring cellular hydroperoxides. One most highly...
Rational Corticosteroid therapy plays a key role in the treatment of COVID-19 patients with respiratory failure. However, rebound phenomenon after steroid cessation rarely occurs. Here, we investigated clinical features therapy. Methods In total, 84 treated corticosteroids were enrolled and analysed retrospectively. A was defined as when patient’s status deteriorated corticosteroid therapy, without secondary bacterial infection. Results Subjects group more likely to having severe failure...
ABSTRACT Excessive inflammation reactions with a cytokine storm in the lungs have historically been thought as primary cause of fatal acute respiratory distress syndrome (ARDS). However, interruption inflammatory activation failed to attenuate ARDS, suggesting that other therapies are required treat this illness and improve survival. Etoposide (ET), cytotoxic agent, prednisolone (PSL), corticosteroid strong anti-inflammatory activity, used disease involving similar cytokine-activated...
Shiga toxin-producing Escherichia coli (STEC) can cause severe gastrointestinal disease and colonization among food handlers. In Japan, STEC infection is a notifiable disease, handlers are required to undergo routine stool examination for STEC. However, the molecular epidemiology of not entirely known. We investigated genomic characteristics from patients asymptomatic in Miyagi Prefecture, Japan. Whole-genome sequencing (WGS) was performed on 65 isolates obtained 38 27 by public health...
We report a severe case of Chromobacterium haemolyticum pneumonia associated with near-drowning and detail the investigation pathogen river water. Our genomic environmental demonstrated that water in temperate region can be source C. causing human infections.
Erlotinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, which effective treatment for patients with non-small cell lung cancer (NSCLC), especially those harboring activating EGFR mutations. A previous phase III trial suggested that wild-type (EGFR-wt) NSCLC or elderly disease progression after cytotoxic chemotherapy might benefit from erlotinib monotherapy. However, few studies have prospectively evaluated the efficacy and safety of second- third-line monotherapy...
Human pulmonary dirofilariasis (HPD) is a zoonotic disease caused by Dirofilaria immitis. Most HPD cases are asymptomatic and either detected during annual health checkups or incidentally identified the investigation of other diseases, particularly primary metastatic lung cancers. However, frequency clinical features Japanese patients with remain unclear. We analyzed data from Medical Abstract Society database 69 between 1978 2022. The incidence increased until 2000s but declined markedly in...
Acute respiratory distress syndrome (ARDS) is the leading cause of mortality in hospitalized patients with coronavirus disease 2019 (COVID-19) because limited effective therapies. During infection, accumulation and activation macrophages monocytes lungs induce inflammatory mediators contribute to tissue injury, ARDS. However, therapeutic strategies that directly target activated macrophage have not been reported. Combination treatment etoposide (a cytotoxic agent) a corticosteroid has widely...
TAFRO syndrome, a subtype of idiopathic multicentric Castleman disease, is an acute or subacute systemic inflammatory disease that causes fever, generalized oedema (pleural effusion ascites), and thrombocytopenia associated with renal impairment, anaemia, organomegaly (hepatosplenomegaly lymph node enlargement). Coronavirus 2019 (COVID-19)-associated hyperinflammation caused by dysregulation proinflammatory cytokines. Cytokine storm syndrome common to both COVID-19 syndrome.Case report.A...
Introduction. This is the first case report of septic abortion due to β-lactamase-negative ampicillin-resistant (BLNAR) non-typeable Haemophilus influenzae infection. In Japan, BLNAR H. widespread and has become a clinical concern, especially in paediatrics otolaryngology, but not been previously recognized as causative agent obstetric or gynaecological Case presentation. A 31-year-old pregnant woman presented at 17 weeks 6 days gestation with high fever; she was admitted diagnosis...